Anna Kuchnio, PhD¹, Elsie Samakai, PhD^2*, Eva Hug, PhD^3*, Meritxell Balmaña, PhD^3*, Lut Janssen, MSc^1*, Ricardo Amorim, PhD^1*, Ivo Cornelissen, MSc^1*, Andrea Majoros, PhD^3*, Michaël Broux, PhD^1*, Isha Taneja, PhD^2*, Vince Torti, PhD^4*, Azra Agic, MSc^3*, Stefan Moritsch, PhD^3*, Filippo Benedetti, PhD^3*, Felix Rosebrock, MSc^3*, Kathryn Packman, PhD^5*, Janine Arts, PhD^6*, Sonal Patel, PhD^7*, Oliver Christopher Lomas, MD, PhD⁸, M. Phillip Deyoung, PhD², Oleh Zagrijtschuk, MD, MSc, MBA^3*, Yusri Elsayed, MD, MMSc, PhD⁹, Stefan Constantinescu, MD, PhD^10,11,12,13*, Robert Kralovics, PhD^14* and Ulrike Philippar, PhD¹⁵

¹Janssen Research & Development, Beerse, Belgium
²Janssen Research & Development, Spring House, PA
³MyeloPro Diagnostics and Research GmbH, Vienna, Austria
⁴Janssen Research & Development, La Jolla, CA
⁵Janssen Research & Development, LLC, Cambridge, MA
⁶Janssen Scientific Innovation Oncology, Beerse, Belgium
⁷Janssen Scientific Innovation Oncology, London, United Kingdom
⁸Janssen Research & Development, High Wycombe, United Kingdom
⁹Janssen Research & Development, LLC, Spring House, PA
¹⁰Ludwig Institute for Cancer Research, Brussels, Belgium
¹¹De Duve Institute, UCLouvain, Brussels, Belgium
¹²Wel Research Institute, Welbio Department, Wavre, Belgium
¹³Nuffield Department of Medicine, Ludwig Cancer Research Oxford, University of Oxford, Oxford, United Kingdom
¹⁴Medical University of Vienna, Vienna, Austria
¹⁵Janssen Research & Development, LLC, Beerse, Belgium

Daniel C Choi, MD¹, Ghaith Abu-Zeinah, MD¹, Pouneh Kermani, PhD^2*, Nassima Messali, PhD², Maria Mia Yabut, MS^2*, Katie Erdos^1* and Joseph M. Scandura, MD, PhD, MS¹

¹Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
²Weill Cornell Medicine, New York, NY

Lilian Varricchio, PhD^1*, Gohar Mosoyan^2*, Sebastian Elghaity-beckley^1*, John Mascarenhas, MD^1* and Ronald Hoffman, MD³

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

Ruggiero Norfo^1,2*, Chiara Carretta^1*, Sandra Parenti^1*, Filippo Badii^1,3*, Matteo Bertesi^1*, Sebastiano Rontauroli, PhD^1*, Lara Tavernari^1*, Elena Genovese, PhD^1*, Samantha Sperduti^4,5*, Elena Enzo^1*, Margherita Mirabile^1*, Francesca Pedrazzi^1*, Chiara Pessina^6*, Ilaria Colugnat^6*, Barbara Mora, MD^7*, Monica Maccaferri, MD^8*, Elena Tenedini, PhD^9,10*, Silvia Martinelli, PhD^11*, Elisa Bianchi, PhD^1*, Livio Casarini^4,5*, Leonardo Potenza, MD, PhD^10*, Mario Luppi, MD^8*, Enrico Tagliafico^10*, Paola Guglielmelli, MD, PhD¹², Manuela Simoni^4,5*, Francesco Passamonti, MD^13*, Alessandro Maria Vannucchi¹⁴ and Rossella Manfredini, PhD, BSc^1,2*

¹Centre for Regenerative Medicine "S. Ferrari", University of Modena and Reggio Emilia, Modena, Italy
²Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
³Department of Cancer Biology, Thomas Jefferson University and Sidney Kimmel Cancer Center, Philadelphia, PA
⁴Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
⁵Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy
⁶SMeL Citogenetica e Genetica Medica, ASST Sette Laghi, Varese, Italy
⁷Division of Hematology, Ospedale ASST Sette Laghi, Varese, Italy
⁸Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy
⁹Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics Unit, Modena University Hospital, Modena, Italy
¹⁰Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AUSL/AOU Policlinico, Modena, Italy
¹¹Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics Unit, Azienda Ospedaliera Universitaria di Modena, Modena, Italy
¹²Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
¹³Dipartimento di Oncologia ed Ematologia, Università degli Studi di Milano, Policlinico di Milano, Ospedale Maggiore, Fondazione I.R.C.C.S. Ca Granda, Milano, Italy
¹⁴CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy

Jenny Huo^1*, George S. Laszlo, PhD^1*, Sheryl Y. T. Lim, DPhil^1*, Frances M. Cole^1*, Allie R. Kehret^1*, Junyang Li^1*, Margaret C. Lunn^1*, Jasmyn L. Persicke^1*, Peter B. Rupert, PhD^2*, Roland K. Strong, PhD^2* and Roland B. Walter, MD, PhD, MS^3,4,5

¹Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
²Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA
³Division of Hematology, Department of Medicine, University of Washington, Seattle, WA
⁴Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA

Kiana K. Guillermo, MS^1*, Stefan Brooks, PhD^2*, Lucas Wadley, BS^2*, Jianhong C Heidmann, BS^3*, Helen Huang^4*, Jane Chen, BS^5*, Aanya Amin^2*, Anaya Qamar^6*, Brianna Hoover, PhD^5*, Gajalakshmi Ramanathan, PhD^2* and Angela G. Fleischman, MD, PhD³

¹Biological Chemistry, University of California, Irvine, Irvine, CA
²University of California, Irvine, Irvine, CA
³Division of Hematology/Oncology, University of California, Irvine, Irvine, CA
⁴Division of Hematology/Oncology, University of California, Irvine, IRVINE, CA
⁵Biological Chemistry, University of California, Irvine, Irvine
⁶University of California, Irvine, Irvine

Warren C. Fiskus, BSc, PhD¹, Prithviraj Bose, MD², Lucia Masarova, MD³, Christopher Peter Mill, PhD, BA⁴, Christine Birdwell, PhD⁴, John Davis^4*, Kaberi Das^1*, Hanxi Hou^2*, Taghi Manshouri, PhD^1*, Kevin Philip^2*, Noor Alhamadani^2*, Alicia Matthews^2*, Sanam Loghavi, MD⁵ and Kapil N. Bhalla, MD³

¹UT MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴MD Anderson Cancer Center, Houston, TX
⁵Hematopathology, MD Anderson Cancer Center, Houston, TX

Tyler M Parsons, PhD¹, Andrew L Young, MD, PhD¹, Daniel A.C. Fisher, PhD^2*, Maggie J Cox^2*, Stephen T. Oh, MD, PhD³ and Grant A Challen, PhD⁴

¹Washington University School of Medicine In St. Louis, Saint Louis, MO
²Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO
³Department of Medicine, Washington University School of Medicine, Saint Louis, MO
⁴Division of Oncology, Washington University School of Medicine, St. Louis, MO

Sara De Santis^1*, Manuela Mancini, PhD^1*, Cecilia Monaldi^2*, Gabriele Gugliotta, MD^3*, Samantha Bruno, PhD^1*, Fausto Castagnetti, MD, PhD^1,3, Miriam Iezza, MD^1*, Marco Cerrano, MD^4*, Alessandra Iurlo, MD, PhD^5*, Sara Galimberti, MD, PhD^6,7*, Serena Balducci^6*, Fabio Stagno, MD, PhD⁸, Michele Cavo, MD^1,3* and Simona Soverini, PhD¹

¹Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna, Bologna, Italy
²Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna, Bologna, AL, Italy
³IRCCS Azienda Ospedaliero–Universitaria di Bologna, Istituto di Ematologia "Sèragnoli", Italy, Bologna, Italy, Bologna, Italy
⁴Division of Hematology, Department of Oncology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy
⁵Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁶Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
⁷UO Ematologia, AOU Santa Chiara, Pisa, Italy
⁸Division of Hematology and Bone Marrow Transplant, AOU Policlinico “Rodolico – San Marco”, Catania, Italy

Alma Mansson^1*, Huan Cai, PhD^2*, Juan Pablo Medina Giménez^1*, Leif Stenke, MD, PhD³ and Hong Qian, PhD^2*

¹Center for Hematology and Regenerative Medicine (HERM), Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden
²Center for Hematology and Regenerative Medicine (HERM), Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
³Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, SWE

Shivam Rai^1*, Hui Hao-Shen^1*, Stefan Dirnhofer^2*, Julien Roux^3*, Rajbharan Yadav^4*, Anamarija Pfeiffer^5*, Jakob Vowinckel^6*, Audrey Arjomandi^7*, Brian Higgins^8,9*, Lyrialle Han^8*, Kerstin Trunzer^10*, Pontus Lundberg^10* and Radek C. Skoda, MD^11,12

¹Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Switzerland
²Institute of Pathology, University Hospital Basel, Basel, Switzerland
³University of Basel and University Hospital Basel, Basel, Switzerland
⁴Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, CA
⁵Biognosys AG, Zurich, Switzerland
⁶Biognosys AG, Schlieren, Switzerland
⁷Genentech, Inc., South San Francisco, CA
⁸Genentech Inc., South San Francisco, CA
⁹Roche Innovation Center, New York, NY
¹⁰F. Hoffmann-La Roche Ltd., Basel, Switzerland
¹¹University Hospital Basel, Basel, Switzerland
¹²Experimental Hematology, Department of Biomedicine, University Hospital and University, Basel, Switzerland

Swarna Bale, PhD¹, Chulwoo J. Kim^1*, Joan How, MD^2,3,4, Mohammed Wazir⁵, Lachelle D. Weeks, MD, PhD^3,6, Maximilian Stahl, MD⁷, Marlise R. Luskin, MD³, Daniel J. DeAngelo, MD³, Coleman Lindsley, MD, PhD⁸, Annette S. Kim, MD, PhD⁹, Ann Mullally, MD^2,3,10 and Anna E. Marneth, PhD^2,11

¹Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
²Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medical Oncology, Massachusetts General Hospital, Boston, MA
⁵Department of Medicine, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA
⁶Center for Prevention of Progression, Dana-Farber Cancer Institute, Boston, MA
⁷Dana Farber Institute, Boston, MA
⁸Dana-Farber Cancer Institute, Boston, MA
⁹Department of Pathology, University of Michigan, Ann Arbor, MI
¹⁰Broad Institute, Cambridge, MA
¹¹Department of Laboratory Medicine, Division Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands

Matthew C. Stubbs, PhD¹, Michelle Pusey^1*, Xiaoming Wen^1*, Katherine Drake^1*, Nina Zolotarjova^1*, Amanda Smith^1*, Maryanne Covington^1*, Guofeng Zhang¹, Ricardo Macarrón, PhD² and Sunkyu Kim^1*

¹Incyte Research Institute, Wilmington, DE
²Incyte, Wilmington, PA

Daniele Tibullo^1*, Mariarita Spampinato^2*, Andrea Duminuco^2,3*, Enrico La Spina^4*, Sebastiano Giallongo^5*, Alessandra Romano, MD, PhD^6*, Grazia Scandura^4*, Tatiana Zuppelli^5*, Rosario Caltabiano^5*, Lucia Salvatorelli^5*, Giovanni Li Volti^5*, Francesco Di Raimondo, MD⁷, Cesarina Giallongo, PhD^8* and Giuseppe Alberto Palumbo, MD^9*

¹Università degli Studi di Catania, Catania, ITA
²university of catania, catania, Italy
³Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁴Divisione di Ematologia, Dipartimento di Chirurgia e Specialità Medico Chirurgiche, Università degli Studi di Catania, Catania, Italy
⁵University of catania, catania, Italy
⁶Divisione di Ematologia, Dipartimento di Chirurgia e Specialità Medico Chirurgiche, Università degli Studi di Catania, Tremestieri Etneo, Cantania, Italy
⁷Haematology, A.O.U. Policlinico “G. Rodolico-San Marco”, Catania, Italy
⁸Università degli Studi di Catania, Catania, CT, ITA
⁹Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania, Catania, Italy

Howard Lin

Baylor College of Medicine, Houston, TX

Min Lu, PhD, MD¹, Lijuan Xia^2* and Ronald Hoffman, MD^3,4

¹Division of Hematology/Oncology, Tisch Cancer Institute and Department of Medicine, Myeloproliferative Neoplasm-Research Consortium,, Icahn School of Medicine at Mount Sinai, Elmhurst, NY
²Division of Hematology/Oncology, Tisch Cancer Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
³Mount Sinai - NY, New York, NY
⁴Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

Alessandro Malara^1*, Daniele Capitanio^2*, Francesca Rossella Calledda^3*, Vittorio Abbonante, PhD^3,4*, Daniele Cattaneo, MD^5*, Alessandra Iurlo, MD, PhD^6*, Cecilia Gelfi^2,7* and Alessandra Balduini, MD³

¹Department of Molecular Medicine, University of Pavia, Pavia, Italy
²Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
³University of Pavia, Pavia, ITA
⁴Department of Health Sciences, Magna Graecia University, Catanzaro, Italy
⁵Hematology, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
⁶Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
⁷Laboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

Giacomo Coltro, MD^1,2*, Viola Videschi, MS^3*, Francesca Gesullo, BiSc^1,2*, Manjola Balliu, PhD^1,2*, Alessandro M. Vannucchi, MD^1,4* and Paola Guglielmelli, MD, PhD^1,5

¹CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
²Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
³University of Florence, School of Medicine, Florence, Italy
⁴University of Florence, CRIMM, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
⁵CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy