Gregory R Keele, PhD^1*, Nadia Holness^2*, Arijita Jash, PhD^3*, Ariel M Hay^3*, Sarah Ewald, PhD^2*, Gary A Churchill, PhD^4*, Angelo D'Alessandro, PhD^5,6, Monika Dzieciatkowska, Ph.D^7,8* and James C Zimring, MD, PhD^9*

¹RTI International, Research Triangle Park, NC
²University of Virginia School of Medicine, Charlottesville
³University of Virginia, Charlottesville, VA
⁴Jackson Laboratory, Chapel Hill, NC
⁵Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁶Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁷University of Colorado, Aurora, CO
⁸University of Colorado Denver - Anschutz Medical Campus, Aurora, CO
⁹University of Virginia School of Medicine, Charlottesville, VA

Pengfei Liang, PhD¹, Yang Zhang^1*, Yui Chun Serena Wan^1*, Shang Ma^2*, Ping Dong^1*, Augustus Lowry^3*, Samuel Francis, MD¹, Sanjay Khandelwal, PhD^4*, Martha Delahunty, PhD^5*, Marilyn J. Telen, MD⁶, John J Strouse, MD, PhD⁷, Gowthami Arepally, MD^1* and Huanghe Yang, PhD³

¹Duke University, Durham
²UT Southwestern Medical Center, Dallas, TX
³Duke University School of Medicine, Durham, NC
⁴Duke Medical Center, Durham, NC
⁵Duke Comprehensive Sickle Cell Center, Duke Univ. School of Medicine, Durham, NC
⁶Duke Univ. Med. Ctr., Durham, NC
⁷Department of Medicine, Division of Hematology, Duke University School of Medicine, Durham, NC

Zhangli Peng, PhD¹, Alexis Moreau^2*, François Yaya^3*, Huije Lu^4*, Anagha Surendranath^3*, Anne Charrier^3*, Benoit Dehapiot^3*, Emmanuelle Helfer^3* and Annie Viallat^3*

¹Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL
²Yale University, New Haven, CT
³Aix Marseille Université, Marseille, France
⁴University of Illinois Chicago, Chicago, IL

Zesen Lin, BS¹, Ginette Balbin-Cuesta, MD, PhD², Greggory Myers, B.S.³, Lei Yu^4*, Claire Drysdale, BSc⁵, Vi Tang^6*, Ayse Bilge Ozel, M.S., Ph.D.^7*, Ann Friedman, B.S.^4*, Beth McGee^8*, Masaki Ito, B.S.^9*, Rilie Saba^10*, Claire Kerpet^11*, Richard King, M.D.¹², Gallagher Patrick^11*, James Engel, Ph.D.⁵ and Rami Khoriaty, M.D.^4,5,13,14

¹Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI
²Cellular and Molecular Biology Program, University of Michigan Medical School, Northville, MI
³Department of cell and developmental biology, University of Michigan, Ann Arbor
⁴Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
⁵Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI
⁶Univeristy of Michigan, Ann Arbor, MI
⁷Department of Human Genetics, University of Michigan, Ann Arbor, MI
⁸Howard Hughes Medical Institute, Ann Arbor, MI
⁹College of Literature, Science, and Arts, University of Michigan, Ann Arbor, MI
¹⁰University of Michigan, Ann Arbor
¹¹University of Michigan, Ann Arbor, MI
¹²Department of Internal Medicine, University of Michigan, Ann Arbor, MI
¹³Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI
¹⁴University of Michigan Rogel Cancer Center, Ann Arbor, MI

Shijie Zhang^1*, Peijun Jia^1*, Qinfeng Peng^2*, Jiaming Cao^1*, Yuanlin Xu^3*, Chao Jiang^4*, Hongtao Ji^5*, Fuyou Guo^6*, Yan Li^1*, Jingxin Zhang^1*, Huan Zhang^1*, Jiaxin Li^2*, Ying Zhang^1*, Xinyang Zhao, PhD⁷, Xuemei Chen^2*, Jian Wang^2* and Xiuli An^8*

¹School of Life Sciences, Zhengzhou University, Zhengzhou, China
²Department of Anatomy, Zhengzhou University, Zhengzhou, China
³Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
⁴The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁵Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China
⁶The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁷University of Alabama At Birmingham, Birmingham, AL
⁸New York Blood Center, New York

Priti Azad, PhD¹, Dan Zhou^1*, Tariq M Rana^1* and Gabriel Haddad, MD^2*

¹University of California San diego, La Jolla, CA
²University of California San Diego, La Jolla, CA

Narges Pourmandi^1*, Greggory Myers, B.S.², Kelsey Temprine, PhD^3*, Amanda Sankar, MD⁴, Noah Nelson^5*, Yatrik Shah, Ph.D.^6*, Costas Lyssiotis, Ph.D.^7*, James Engel, Ph.D.² and Rami Khoriaty, M.D.^2,8,9,10

¹Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
²Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI
³Cancer Biology, University of Michigan, Ann Arbor
⁴Nationwide Children's Hospital, Columbus, OH
⁵Molecular & Integrative Physiology, University of Michigan, Ann Arbor
⁶University of Michigan, Ann Arbor
⁷Rogel Cancer Center, University of Michigan, Ann Arbor, MI
⁸Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
⁹Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI
¹⁰University of Michigan Rogel Cancer Center, Ann Arbor, MI

Zohreh Safari, PhD^1*, Stephen C Rogers, PhD^1*, Mary E Brummet^1*, Qihong Wang^1*, Joy Okhuevbie^1*, Aaron Issaian^2*, Monika Dzieciatkowska, Ph.D^3*, Fabia Gamboni^3*, Jason Held, PhD^4*, Angelo D'Alessandro, PhD³, Miriam Cortese Krott, PhD^5* and Allan Doctor, MD¹

¹University of Maryland school of Medicine, Baltimore, MD
²University of Colorado Anschutz Medical Campus, Aurora, CO
³University of Colorado, Aurora, CO
⁴Washington University in St. Louis, St. Louis, MO
⁵Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

Zhangbiao Long, M.D., Ph.D.^1*, Jichun Yang, Ph.D.^2*, Xinyao Liu^3*, Min Ruan^3*, Danchen Meng^3*, Junling Zhuang, MD, PhD⁴, Zhenqi Huang, M.D., Ph.D.^5*, Jian Ge, PhD^6* and Bing Han^7*

¹Hematology department, The first affiliated hospital of Anhui medical university, Beijing, China
²School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
³Hematology department, The first affiliated hospital of Anhui medical university, Hefei, China
⁴Peking Union Medical College Hospital,Chinese Academy of Medical Sciences, Beijing, China
⁵Hematology department, The first affiliated hospital of Anhui medical university ,Shushan district, Hefei, China
⁶Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
⁷Peking Union Medical College Hospital, Beijing, China

Massiel Chavez Stolla, PhD¹, Raymond T. Doty, PhD^1*, Janis L. Abkowitz, MD¹ and Sergei Doulatov, PhD^2,3,4

¹Department of Medicine, University of Washington, Seattle, WA
²Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA
³Department of Genome Sciences, University of Washington, Seattle, WA
⁴Division of Hematology, Department of Medicine, University of Washington, Seattle, WA

Zachary D Hanson, DO, MA¹, Hamid Mirshahidi, MD^2*, Joel Brothers, MD², Saied Mirshahidi, PhD^2*, Brian Pham, MD³, Ravand Samaeekia, MD^3* and Mojtaba Akhtari^2*

¹Cancer Center, Loma Linda University Medical Center, Redlands, CA
²Cancer Center, Loma Linda University Medical Center, Loma Linda, CA
³Loma Linda Medical Center, Loma Linda, CA

Greggory Myers, B.S.¹, Ann Friedman, B.S.^2*, Lei Yu^1*, Claire Kerpet, B.S.^2*, Masaki Ito, B.S.^3*, Rilie Saba^3*, Ginette Balbin-Cuesta, MD, PhD^4,5, Zesen Lin, BS⁶, Claire Drysdale, BSc^1,4, Ayse Bilge Ozel, M.S., Ph.D.^7*, James Engel, Ph.D.¹ and Rami Khoriaty, M.D.^1,2,8,9

¹Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI
²Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
³College of Literature, Science, and Arts, University of Michigan, Ann Arbor, MI
⁴Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI
⁵Cellular and Molecular Biology Program, University of Michigan Medical School, Northville, MI
⁶Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI
⁷Department of Human Genetics, University of Michigan, Ann Arbor, MI
⁸Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI
⁹University of Michigan Rogel Cancer Center, Ann Arbor, MI

Xijuan Lin^1*, Chen Yang^2*, Junling Zhuang, MD, PhD³, Daobin Zhou, MD^4*, Miao Chen^5* and Bing Han, MD, PhD^6*

¹Peking Union Medical College, Beijing, China
²Peking Union Medical College Hospital, Beijing, China
³Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
⁴Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
⁵Peking Union Medical College Hospital,Chinese Academy of Medical Sciences, Beijing, China
⁶Dept. of Hematology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing, China

Shobhita Katiyar, PhD^1*, Arunim Shah^2*, Khaliqur Rahman^2*, Soniya Nityanand, MD, PhD³ and Chandra Prakash Chaturvedi^2*

¹Department of Hematology, SGPGIMS, Sanjay Gandhi Post Graduate of Institute of Medical Sciences, Lucknow, India
²Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
³Dr Ram Manohar Lohia Institute of Medical Sciences, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India

Jordan Nunnelee, MD¹, Mindy Kohlhagen, BS^2*, Sheila Moldenhauer^3*, Maggie DiGuardo^3*, David L Murray, MD, PhD^2*, Anand Pabmanabhan, MBBS, PhD² and Ronald S. Go, MD³

¹Internal Medicine, Mayo Clinic, Rochester, MN
²Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
³Mayo Clinic, Rochester, MN

Laurel Romano, PhD^1*, Athina Ntoumaziou, MD^2*, Jason C Gardner, PhD^3*, Maria Stewart^4*, Robert Paulson, PhD⁵, Nathan Salomonis, PhD^6*, Lionel Blanc, PhD⁷, Katie Seu, PhD^2,8 and Theodosia A. Kalfa, MD, PhD^2,8

¹Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati, Cincinnati, OH
⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA
⁶Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁷Feinstein Institutes for Medical Research, Northwell, Manhasset, NY
⁸Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

Catherine M. Broome, MD¹, Wilma Barcellini, MD^2*, Yasutaka Ueda^3*, Umer Khan^4*, Reena Patel^5*, Marek Wardęcki^6*, Katarina Kralova^7*, Shruti Srivastava^8* and Alexander Röth, MD⁹

¹Division of Hematology, MedStar Georgetown University Hospital, Washington, DC
²Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
³Osaka University Graduate School of Medicine, Suita, Japan
⁴Sanofi, Cambridge, MA
⁵Sanofi, Boston, MA
⁶Sanofi, Warsaw, Poland
⁷Sanofi, Paris, France
⁸Sanofi, Bridgewater, NJ
⁹Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany

Yuanlin Xu^1*, Yating Li^2*, Wanxin Li^3*, Yazhe Zhen^3*, Peijun Jia^3*, Yan Li^4*, Jingxin Zhang^3*, Huan Zhang^3*, Jiaming Cao^3*, Ying Zhang^3*, Xinyang Zhao, PhD⁵, Xiuli An, MD, PhD⁶ and Shijie Zhang^3*

¹Zhengzhou University, Zhengzhou, Henan, China
²School of Life Sciences, Zhengzhou University, Zhengzhou, AL, CHN
³School of Life Sciences, Zhengzhou University, Zhengzhou, China
⁴Sichuan University, Sichuan University, Chengdu, China
⁵University of Alabama At Birmingham, Birmingham, AL
⁶Laboratory of Membrane Biology, New York Blood Center, New York, American Samoa

Caroline I Piatek, MD¹, Irina Murakhovskaya, MD², Alia Karaouni, PhD^3*, Gandarvaka Miles, MPH, PhD^4*, Carrie Heller, MPH^5*, Jacqueline Lucia, BS^6*, Reena Patel^5*, Jennifer Tyma, PhD^5*, Ronnie Yoo^4* and Morie A. Gertz, MD⁷

¹Jane Anne Nohl Divison of Hematology, Keck School of Medicine, University of Southern California, Los Angeles, CA
²Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY
³BMAPS SARL, Geneva, Switzerland
⁴Sanofi, Cambridge, MA
⁵Sanofi, Boston, MA
⁶Aetion, New York City Metropolitan Area, NY
⁷Department of Medicine, Division of Hematology,, Mayo Clinic, Rochester, MN