IonOpticks

We’re excited to welcome Marten Winge, a seasoned life sciences expert with a proven track record in advancing healthcare solutions, to our Board of Directors. With his guidance, IonOpticks is well-positioned to continue delivering high-quality tools for impactful research and expand our reach to better serve customers worldwide. Welcome, Mårten!

Say hi to Jenna, because you’ll see and hear a lot more from her - both at upcoming conferences and in taking care of all your support needs. Reflecting our ongoing commitment to excellence in customer service at IonOpticks, Jenna joins us as our dedicated Customer Experience Manager. Even before her title reflected it, Jenna has long been customer-focused, with a background in project management and operations. She earned an MSc in Real Estate at a commercial property consultancy in Leeds before moving to the Property Tech sector, where she led strategic projects and continuous improvement initiatives to enhance customer experience. Now, as IonOpticks' Customer Experience Manager, Jenna is excited to immerse herself in the world of proteomics and make a meaningful impact by enhancing the experience you have with our brand and products, at every point of the customer journey. Outside of work, you’ll find Jenna experimenting with new recipes, exploring the city, and trying out new restaurants. Having lived in many different cities, she’s developed an appreciation for diverse food scenes and new experiences. Join us as we warmly welcome Jenna to #teamIO.

Bruker Daltonics' latest application note highlights that ultra-high-throughput proteomics doesn’t have to compromise depth or quality. Pairing a timsTOF HT with an Aurora Rapid 5x75 column, the researchers identified over 7,200 protein groups and 85,658 precursors in just 5 minutes. With outstanding reproducibility across 10 labs and multiple users, this combination is great for reducing sample queues when speed is paramount. Learn more in the full app note below. PreOmics NEOsphere Biotechnologies GmbH University Medical Center Mainz USI Università della Svizzera italiana Helmholtz Munich

New research advances mitochondrial disease diagnostics: A recent study by Correia et al., combining proteomics with genetic analysis, has identified seven potential biomarkers for mitochondrial diseases. Learn more: https://bit.ly/4htwtKZ Researchers out of the Wredenberg lab analyzed fibroblasts from 67 patients and 17 controls, identifying 5,888 unique proteins. The study revealed distinct proteomic signatures for different mitochondrial disease groups and demonstrated how proteomics can support genetic diagnoses. This breakthrough could significantly improve diagnostic workflows and treatment monitoring for mitochondrial diseases. The chromatographic separation achieved with the Aurora Ultimate column enabled high-quality targeted proteomics validation and facilitated the identification of disease-specific protein signatures. Learn more: https://bit.ly/4htwtKZ

With fantastic presentations by Karl Mechtler, Jesper Olsen, Erwin Schoof and Fabian Coscia, it was easy to stay engaged as #iSCMS2024 has come to its end. It’s been an honour supporting the single-cell proteomics community at DTU - Technical University of Denmark as a Silver Sponsor of iSCMS 2024. We can't wait to see it keep growing and are honoured to support its growth. Thank you for putting on such a rich and engaging event.

Please welcome Jackie, our new Finance & Payroll Officer. Having recently moved to Melbourne from Hobart, Jackie is a CPA with a Bachelor of Business in Accounting. She lived her enthusiasm for budgeting and risk management in her eight years working in management accounting and payroll at a not-for-profit and two years as an Operations Manager in a travel agency. Inspired by IonOpticks' global impact on the research community, Jackie is excited to join the team and ensure compliance, accuracy, and efficiency while supporting the company's rapid growth. When she’s not balancing the books, she’s busy balancing life with her husband, toddler, and their senior dog, who are always up for exploring new places. Being a finance nerd at heart, she's also passionate about studying finance, with the long-term goal of helping others break free from financial stress and achieve true financial freedom.

Great poster by Evosep Biosystems at #iSCMS2024, demonstrating substantial improvements in retention time stability and reproducibility. Using the Aurora Rapid 5x75 and Aurora Elite 15x75 columns, the Whisper Zoom 80 SPD method delivers sharper, more consistent peak widths across instruments, while the Whisper Zoom 120 SPD achieves optimal sensitivity at just 10 ng of HeLa peptides. This combination clearly enables precise, scalable single-cell analysis with enhanced depth and reproducibility.

The molecular architecture of the SARS-CoV-2 double-membrane vesicle (DMV) pore complex, a crucial component in coronavirus replication, has been unveiled in a study by Huang et al. Using cryogenic electron tomography and subtomogram averaging, the researchers resolved the structure of the nsp3-nsp4 pore complex at 4.2 Å resolution. This research provides a groundwork to understand DMV pore formation and RNA translocation in the Coronaviridae family, potentially extending to other viruses in the Arteviridae family of Nidovirale. An IonOpticks Aurora Ultimate column enabled high-resolution chromatographic separation for the mass spectrometry analysis. Learn more: https://bit.ly/3YD3xJb Nature Magazine Nature Portfolio The University of Hong Kong The Hong Kong Polytechnic University Bruker Daltonics Shuofeng Yuan

Great poster presentation by Bruker's Christoph Krisp on Day 1 of iSCMS 2024, demonstrating the timsTOF Ultra 2’s power in single-cell analysis, identifying over 4,000 protein groups per HeLa cell in dia-PASEF mode. Using Cellenion's cellenONE + proteoCHIP for sample prep, and Evosep Biosystems' Whisper Zoom methods, Christoph showcased reproducible, high-sensitivity results in scalable workflows up to 1080 SPD with Aurora Series columns used for superior separation with the timsTOF Ultra 2. The optimised labeling workflow also enabled rapid cell-type screening with protein-RNA profile correlations, advancing efficient phenotyping.

It’s a pleasure to be joining Erwin M. Schoof and the single-cell proteomics community at DTU - Technical University of Denmark for #iSCMS 2024. We extend our thanks for such a warm welcome on our first visit to this beautiful country. A rich and engaging (and novel) opening session delivered by keynote speaker Neil Kelleher and a great variety of single cell poster presentations to kick start day 1. Stop by the IonOpticks stand to learn more about how we can help you optimise sensitivity and coverage in your single-cell research.