Allergy EAACI

#Airway #inflammation is a central feature of respiratory disorders, characterized by the infiltration of immune cells into the upper and lower respiratory mucosa. This inflammatory response leads to structural changes, including airway wall thickening, mucus overproduction, and epithelial barrier defects in the affected respiratory tissues. Consequently, these alterations result in persistent respiratory symptoms. In this issue, Kistler et al. provide a comprehensive overview of how exposure to toxic substances disrupts epithelial barriers, increasing the risk of microbial dysbiosis and inflammation in athletes. Van Duuren and van Hengel et al. discuss risk factors and preventive measures concerning respiratory tract infections in preterm-born inflants. Jackson et al. review the existing real-world and clinical study data of anti-IL-5/anti-IL-5R therapies in severe eosinophilic asthma. Goksel et al. investigate the effect of respirable <PM2.5 inorganic silica particle exposures on epithelial barrier integrity. Melgaard et al. provide insight into the interplay between early-life viral infections, airway immunity and asthma development. Rhee, Henderson and Bauer et al. evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of MTPS9579A, an anti-tryptase antibody, in a phase 2a randomized trial for patients with uncontrolled asthma and a phase 1c trial focused on its activity in the lower respiratory tract. The study by Vázquez-Mera et al. confirms the expansion of CD4+CD26−/lo TEM/EMRA lymphocytes in allergic asthma, suggesting their role in long-term inflammation. Feleszko and Makrinioti et al. investigate whether exposure to residential greenness between birth and bronchiolitis hospitalization is associated with asthma and atopic asthma development by age 6 years. Irizar et al. assess early-life exposure to air toxics and its association with the development of allergic rhinitis. Wisgrill et al. examine age-dependent developmental differences and antiviral responses of nasal epithelial cells to influenza A and respiratory syncytial virus. Connell et al. investigate the bacterial and fungal microenvironment of allergic fungal rhinosinusitis. Khalmuratova and Ryu et al. study the role of neuropilin-1 in chronic rhinosinusitis with nasal polyps. Huber et al. assess the 3-year impact of sustained dupilumab therapy for chronic rhinosinusitis with nasal polyps. Fricker et al. demonstrate that mepolizumab depletes inflammatory but preserves homeostatic eosinophils in severe asthma. Sohail et al. anaylze the expression profiles and potential functions of IL-5 receptors in sinonasal epithelial cells. Khatri et al. investigate the effect of probiotic formulation on humanized mouse model of allergen-induced lung and gut inflammation. Tynecka and Janucik et al., show that adipose tissue-derived mesenchymal stromal cells are effective in the regulation of mixed granulocytic house dust mite-induced asthmatic inflammation. journalallergy.com

Open Access: The IL-4–IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell. First authors: Yannis H. and Mithilesh Kumar Jha; corresponding author: Alexandra Hicks Read the article here: doi.org/10.1111/all.16338 IL-4 and IL-13 have non-redundant effects in olfaction, with loss of smell in mice evoked only by intranasal administration of IL-4, but not IL-13. IL-4-evoked pathophysiological effects on olfaction is independent of compromised structural integrity of the olfactory neuroepithelium. IL-4–IL-4Rα signaling modulates neuronal crosstalk with immune cells, suggesting a functional link between olfactory impairment and neuroinflammation. #Allergy_journal Read more articles published in #Allergy on basic and translational energy here: https://lnkd.in/dpDb3WDz

📢One of the most appreciated/liked articles in the social media of Allergy published in 2023: Immunoglobulin E autoantibodies in atopic dermatitis associate with Type-2 comorbidities and the atopic march. First and corresponding author: Inge Kortekaas Krohn Read the article here: doi.org/10.1111/all.15822 This study investigates the prevalence of IgE-mediated autoreactivity in serum samples from a well-characterized large cohort of #atopicdermatitis (AD) patients and controls and their correlation with clinical characteristics and environmental factors potentially related to the development of IgE #autoantibodies in AD. IgE autoantibodies in AD associate with the presence of atopic comorbidities and the atopic march. AD-patients with IgE autoantibodies were younger than those without and higher total serum IgE levels were found. Environmental factors that affected IgE autoantibodies were birth between January and June, c-section and diversity of domestic pets. #Allergy_journal Read more articles published in #Allergy on atopic #dermatitis here: https://lnkd.in/dvN_pd2

Inge Kortekaas Krohn from the Universitair Ziekenhuis Brussel/ Vrije Universiteit Brussel, Belgium, presents their EAACI Task Force Report published in Allergy: Kortekaas Krohn I, Callewaert C, Belasri H, et al. The influence of lifestyle and environmental factors on host resilience through a homeostatic skin microbiota: An EAACI Task Force Report. Allergy. 2024; Read the article here: https://lnkd.in/d-7bh5Eu #Allergy_journal Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV https://lnkd.in/dmTbf22y

Check out this month’s selection of articles by Allergy’s Editor-in-Chief, Cezmi Akdis: 1. Kistler W, Villiger M, Villiger B, et al. Epithelial barrier theory in the context of nutrition and environmental exposure in athletes. Allergy. 2024; 79: 2912-2923. doi.org/10.1111/all.16221 2. van Duuren IC, van Hengel ORJ, Penders J, Duijts L, Smits HH, Tramper-Stranders GA. The developing immune system in preterm born infants: From contributor to potential solution for respiratory tract infections and wheezing. Allergy. 2024; 79: 2924-2942. doi.org/10.1111/all.16342 3. Jackson DJ, Wechsler ME, Brusselle G, Buhl R. Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents. Allergy. 2024; 79: 2943-2952. doi.org/10.1111/all.16346 4. Goksel O, Sipahi MI, Yanasik S, et al. Comprehensive analysis of resilience of human airway epithelial barrier against short-term PM2.5 inorganic dust exposure using in vitro microfluidic chip and ex vivo human airway models. Allergy. 2024; 79: 2953-2965. doi.org/10.1111/all.16179 5. Jabeen MF, Sanderson ND, Tinè M, et al. Species-level, metagenomic and proteomic analysis of microbe-immune interactions in severe asthma. Allergy. 2024; 79: 2966-2980. doi.org/10.1111/all.16269 6. Darsow, U., Gelincik, A., Jappe, U., Platts-Mills, T.A., Ünal, D. and Biedermann, T. , Algorithms in allergy: An algorithm for alpha-Gal syndrome diagnosis and treatment, 2024 update. Allergy.2024; 79: 3169-3172. doi.org/10.1111/all.16291 7. Beerweiler CC, Salvermoser M, Theodorou J, et al. Farm-dust mediated protection of childhood asthma: Mass cytometry reveals novel cellular regulation. Allergy. 2024; 79: 3022-3035. doi.org/10.1111/all.16347 8. Feleszko W, Makrinioti H, Nalej M, et al. Early-life exposure to residential greenness and risk of asthma in a U.S. bronchiolitis cohort. Allergy. 2024; 79: 3036-3046. doi.org/10.1111/all.16359 9. Irizar H, Chun Y, Hsu H-H, et al. Multi-omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis. Allergy. 2024; 79: 3047-3061. doi.org/10.1111/all.16174 10. Connell JT, Bouras G, Yeo K, et al. Characterising the allergic fungal rhinosinusitis microenvironment using full-length 16S rRNA gene amplicon sequencing and fungal ITS sequencing. Allergy. 2024; 79: 3082-3094. doi.org/10.1111/all.16240 11. Huber P, Förster-Ruhrmann U, Olze H, et al. Real-world data show sustained therapeutic effects of dupilumab in chronic rhinosinusitis with nasal polyps (CRSwNP) over 3 years. Allergy. 2024; 79: 3108-3117. doi.org/10.1111/all.16263 12. Fricker M, Harrington J, Hiles SA, Gibson PG. Mepolizumab depletes inflammatory but preserves homeostatic eosinophils in severe asthma. Allergy. 2024; 79: 3118-3128. doi.org/10.1111/all.16267 #Allergy_journal Read all recent papers published in Allergy here: journalallergy.com

Exciting new findings by Heinl et al. showcase how IL-10-modulated dendritic cells can drive both allergen-specific and cross-reactive tolerance in patients allergic to birch pollen and hazelnut. This research offers promising insights into potential treatments for complex allergies. Find the full study here: https://lnkd.in/dU9RA8bG #Immunotherapy #AllergyResearch #DendriticCells #Tregs Allergy EAACI

Open Access: Redefining tryptase norms in the pediatric population reveals sex-based differences: Clinical implications. First author: Mathilde Puel; corresponding author: Laura Polivka Read the article here: doi.org/10.1111/all.16365 A threshold of 8.0 ng/mL serum basal tryptase (sBT) is often used for the diagnosis of mast cell activation disorders. Analysis of data from 398 children and 2204 adults indicates lower levels of tryptase in females after reaching puberty, suggesting a re-evaluation of sBT threshold levels in girls. Read more articles published in #Allergy on #clinicalimmunology here: https://lnkd.in/ex3Y69tY #Allergy_journal

📢One of the most appreciated/liked articles in the social media of Allergy published in 2023: The skin microbiome in the first year of life and its association with atopic dermatitis. First author: Alexis Rapin; corresponding author: Benjamin J. Marsland Read the article here: doi.org/10.1111/all.15671 The skin bacterial community composition varies between individuals after birth, then progressively converges during the first year of life. The skin #microbiome composition and diversity at birth is associated with later onset of atopic #dermatitis with associations found between skin barrier function, dry skin and bacterial communities. Delivery mode and location are major determinants of the skin microbiome at birth. #Allergy_journal Read more articles published in #Allergy on the microbiome here: https://lnkd.in/eCEij5W8

I am pleased to share our recent paper on the newly-defined Type 2 memory B cell (Bmem) subset. We here show expansions of Type 2 Bmem in people with grass pollen allergy and in people with honey bee venom allergy, and how these cells are modified by allergen immunotherapy. A great team effort from the Allergy and Clinical Immunology lab at Monash University and Alfred Health!

Allergy provides the readers with 24 free and open access articles in the November issue! Check out the articles and download freely with one click on the doi link. 1. Angelina, A., Pérez-Diego, M. and Palomares, O., Nutritional and environmental exposures in athletes: Implications on the epithelial barrier function. Allergy, 79: 2909-2911. doi.org/10.1111/all.16280 2. Kistler W, Villiger M, Villiger B, et al. #Epithelialbarriertheory in the context of nutrition and environmental exposure in athletes. Allergy. 2024; 79: 2912-2923. doi.org/10.1111/all.16221 3. van Duuren IC, van Hengel ORJ, Penders J, et al. The developing immune system in preterm born infants: From contributor to potential solution for respiratory tract infections and wheezing. Allergy. 2024; 79: 2924-2942. doi.org/10.1111/all.16342 4. Jackson DJ, Wechsler ME, Brusselle G, Buhl R. Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents. Allergy. 2024; 79: 2943-2952. doi.org/10.1111/all.16346 5. Goksel O, Sipahi MI, Yanasik S, et al. Comprehensive analysis of resilience of human airway #epithelialbarrier against short-term PM2.5 inorganic dust exposure using in vitro microfluidic chip and ex vivo human airway models. Allergy. 2024; 79: 2953-2965. doi.org/10.1111/all.16179 6. Jabeen MF, Sanderson ND, Tinè M, et al. Species-level, metagenomic and proteomic analysis of microbe-immune interactions in severe asthma. Allergy. 2024; 79: 2966-2980. doi.org/10.1111/all.16269 7. Rhee H, Henderson LM, Bauer RN, et al. Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma. Allergy. 2024; 79: 2993-3004. doi.org/10.1111/all.16309 8. Vázquez-Mera S, Martelo-Vidal L, Miguéns-Suárez P, et al. Exploring CD26−/lo subpopulations of lymphocytes in #asthma phenotype and severity: A novel CD4+ T cell subset expressing archetypical granulocyte proteins. Allergy. 2024; 79: 3005-3021. doi.org/10.1111/all.16327 9. Beerweiler CC, Salvermoser M, Theodorou J, et al. Farm-dust mediated protection of childhood asthma: Mass cytometry reveals novel cellular regulation. Allergy. 2024; 79: 3022-3035. doi.org/10.1111/all.16347 10. Wisgrill L, Martens A, Kasbauer R, et al. Network analysis reveals age- and virus-specific circuits in nasal epithelial cells of extremely premature infants. Allergy. 2024; 79: 3062-3081. doi.org/10.1111/all.16196 11. Connell JT, Bouras G, Yeo K, et al. Characterising the allergic fungal rhinosinusitis microenvironment using full-length 16S rRNA gene amplicon sequencing and fungal ITS sequencing. Allergy. 2024; 79: 3082-3094. doi.org/10.1111/all.16240 12. Khalmuratova R, Ryu J-S, Hwang JH, et al. NRP1 antagonism as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. Allergy. 2024; 79: 3095-3107. doi.org/10.1111/all.16285 ed in #Allergy here: journalallergy.com