DataHow AG

💡 In case you missed it! 📣 Watch this recorded webinar on Model-based Upstream Process Optimization and join Dr. Moritz von Stosch and Angela Botros, as they describe how processes can be optimized more effectively, and effieciently using a model-based approach. Key topics include: -         Why process optimization is so complex; -         How to perform process optimization with models and existing data; -         A case study where existing data was leveraged to accelerate process development; -         How wet-labs could be replicated by in silico experimentation. The webinar includes a theoretical perspective as well how to practically implement these approaches using DataHowLab. Watch the recording now: https://lnkd.in/eXPGfADp #webinar #bioprocessing #processoptimization #hybridmodels #datahow

🎓 Advanced Process Data Analytics - Virtual Course   November 13th-15th & 20th-22nd, 2024   Are you ready to take your data analytics skills to the next level? Join us for an immersive 6 half-day course, designed for professionals working with process data. Learn from widely published thought leaders in the field of advanced process data analytics and process modeling methodologies and explore the most advanced analytical methods and techniques.   What you’ll learn:  • Master advanced multivariate data analysis;  • Explore machine learning and hybrid modeling approaches;  • Practical industry case studies with real-world application;  • Insights from industry experts; If you are keen to learn the most advanced methods and technologies that are being adopted by the industry, this course is a must. Click the link for more details and register today - https://lnkd.in/dGRCRMRj #DataScience #AdvancedAnalytics #ProcessDataAnalytics #MachineLearning #AI

Unlike classic experiment design approaches, on-the-fly optimal experimental design increases the amount of information derived from process runs by exploring the temporal domain.   Running a high-throughput bioreactor platform is challenging, but running it for a perfusion mammalian cell culture process is even more difficult. Using a digital twin to support the planning and operation of the runs increases the insight into the process evolution and the information derived from each reactor run, as shown in the latest publication "Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production". The core component of the digital twin is the predictive hybrid model that renders what-if analysis, as well as the exploration of meaningful unseen process regions. If you want to learn more, read the pre-print here: https://lnkd.in/daxyxkev. #bioprocessing #biopharma #biotechnology #CDMO

Meet DataHow at the Festival of Biologics in Basel!   From October 15th to 17th, DataHow will be visiting the center of the Swiss pharmaceutical world in Basel. Join us there at the Festival of Biologics and meet our CCO, Mark Powell, and Machine Learning Engineer, Claus Wirnsperger, to learn more about our technologies and the latest updates from the product and business.    We will be at stand S45, looking forward to connecting with you!   #FestivalOfBiologics #BioprocessModeling #MachineLearning #DataHow #Biopharma

In the biopharmaceutical industry, accurately predicting critical quality attributes (CQAs) while minimizing costly experimental runs has been a long-standing challenge. Traditional “black box” models are the industry standard but are still unable to completely understand the complexities of bioprocesses. Together with Bristol Myers Squibb, we evaluated experimental data from a complex upstream mAbs bioprocess using DataHow’s AI-enabled hybrid process models. The results show that hybrid (AI) models offer significantly more insight than black box models:    • 22% increase in prediction accuracy across CQAs • 3x fewer experiments required to predict CQAs accurately • Richer process knowledge, insights, and control compared to traditional models Want to learn more about how hybrid models can impact process development? Check out our detailed case study, "Understanding and Predicting Product Quality (CQAs) in Process Development" here: https://lnkd.in/g-6dUv68.   #AI #Biopharma #Bioprocessing #DigitalSolutions #HybridModels #ProcessOptimization

We’re excited to be part of CPHI next week! Meet our team in Milan, including our COO, Michael Sokolov, and our CCO, Mark Powell, to discuss how we are impacting bioprocessing for innovators and CDMOs with our innovative AI-enabled technologies and solutions. To continue the conversations, and provide an opportunity to network in an informal setting, we are hosting a dinner on October 9th in Milan. Contact Michael or Mark if you would like to join and connect over great pasta and conversations. We look forward to meeting you there! #CPHI #Biopharma #Networking #IndustryInnovation #Milan2024

🚀What a week in Boston at BioProcess International East 💪🏼 It’s been busy but incredibly valuable to spend time at the heart of the US Pharma industry, building stronger relationships with existing customers, and creating new ones. Michael was on stage supporting the Keynote, where major industry players clearly highlighted the importance of hybrid modeling technology as part of the industry's digital future. A few of our customers were also on stage presenting their incredible work and the results they have achieved using DataHowLab. The interest was felt at our booth where we had many engaging conversations! We also had many productive meetings around the event, both with long-standing partners and newly developing relationships - we will be in Boston again soon! Thanks as well to Jakub, Elena, Mark, and Michael for the incredible energy this week! #BPI #DataHow #hybridmodeling #biopharma #innovation #digital

Register for the 2nd Get-Together, Learn, and Connect afternoon event at the Biopartner Center in Leiden (Netherlands) on October 9, 2024. Securecell AG, Hamilton, and DataHow - three leaders in advanced data gathering, process analytical technology (PAT), and analysis solutions - are excited to organize this Get-Together and invite you to join this exclusive event. The Get-Together fosters open, scientific dialogue and innovation, with little commercial influences. Our focus will be on how digital technologies, advanced modeling, data analytics, and Process Analytical Technology (PAT) are revolutionizing upstream bioprocessing. We aim to explore how these tools can enhance process optimization, improve production outcomes, and drive the future of biomanufacturing. Register now and join the discussion: https://lnkd.in/eDD85ukH #dataintegration #automation #digitalization #bioprocessing #PAT #Hamilton #Securecell #Datahow #bioprocess_optimization

Reusing existing process data to streamline new process development activities can significantly reduce the experimental burden.   In our latest work, we show how transfer learning and meta-learning applied to historical process data can transform how we design and predict new bioprocesses. By leveraging knowledge transfer models, we introduce a novel method, calibration design, that optimizes process design for new campaigns.   Our results suggest that: •  Process understanding is significantly improved when horizontal knowledge transfer methods are used in lieu of single process models; •  Calibration designs allows to systematically carry knowledge over to new process development campaigns; •  Gaussian Process model performance is better when using Latin Hypercube Sampling for data generation than Definite Screening Designs.   Thank you to Laura Marie Helleckes, who accomplished this work during her research stay with us.   If you are curious to know more, here you can find the full text: https://lnkd.in/daxyxkev. #Bioprocessing #Pharma #Pharmaceuticals #MachineLearning #HybridModel #DataScience

🎓 Advanced Process Data Analytics - Virtual Course November 13th-15th & 20th-22nd, 2024 Ready to enhance your data analytics skills? Join us for an immersive 6 half-days virtual course, designed for professionals working with process systems data. Learn from thought leaders in the field of analytics and process modeling methodologies and explore the most advanced analytical methods and techniques. What you’ll gain: • Master advanced multivariate data analysis • Explore machine learning and hybrid modeling • Practical industry case studies with real-world applications • Insights from industry experts If you want to learn the most advanced methods and technologies that are shaping the future of advanced process analytics, this course is a must. Click the link for more details and register today - https://lnkd.in/dGRCRMRj #DataScience #DataAnalyticsCourse #AdvancedAnalytics #ProcessDataAnalytics #MachineLearning