SaferWorldbyDesign

When I joined InSphero just a few weeks ago, I didn’t realize how productive the team is in advancing original research. Now, as I’m enjoying my morning coffee (the scientist in me drinks from a modified beaker!), I couldn’t help but dive into the latest paper from InSphero’s liver safety group, published in Toxicological Sciences in collaboration with the US FDA. Here are the key takeaways (Link to the paper is in the comments): ➡️ 152 FDA-approved drugs were tested with our 3D liver microtissues to assess DILI risk—one of the top reasons for drug development failure. ➡️ Our model flagged 80% of withdrawn drugs due to liver toxicity and classified 89% of safe drugs. For liver-toxic drugs targeting the nervous system, it had a >90% success rate. ➡️ Our 384-well Akura™ Spheroid Microplates enable scalable, automated screening for large-scale hepatotoxicity assessment. ➡️ Complexity isn’t always better—fit-for-purpose complex in vitro models are key for the adoption of NAMs, ensuring biological relevance, faster results, and cost-efficiency. Proud to be part of a team pushing the industry forward! #LiverToxicity #3DCellCulture #Toxicology #DrugDevelopment #InVitroModels #NAMs #InSphero #PharmaInnovation #SafetyScience #Biotech InSphero Arumugham (Ragoo) RaghunathanBärbel UlmerChristine Schwenk Sue Grepper, PhD Bruno Filippi Maria Vittoria Colombo Monika Tu Lola Fäs Friederike Wenz Katarzyna Sanchez Natalia Zapiórkowska-Blumer Hajnalka Varga Karolina Kaczmarska

ECETOC: European Centre for Ecotoxicology and Toxicology of Chemicals #workshop today including a presentation on how Edelweiss Connect (RISK-HUNT3R partner) develops #FAIR (Findable, Accessible, Interoperable, Reusable) datasets and knowledge graphs based on its work supporting #NextGenerationRiskAssessment (#NGRA) & Safe and Sustainable by Design (#SSbD) approaches. All details: https://lnkd.in/dyNrc3Jr #chemical #riskassessment #knowledge #infrastructure #solutions #newapproachmethods #sustainability

Join us at the next #SaferWorldByDesign Workshop on 6 November 2024 in #Basel, Switzerland (or virtually!), we’ll explore how to embed human safety, environmental protection, and sustainability into early product design. Experts will guide us through practical methods using data, AI, and life cycle analysis to make informed, safer choices for our products. See full program and register now: https://lnkd.in/gYDWAH_m #SustainableDesign #ProductSafety #Innovation #EnvironmentalImpact #AIinDesign

Join us for our #SaferWorldByDesign Workshop on 6 Nov 2024 in #Basel or online! #SustainableDesign #ProductSafety #EnvironmentalImpact #InnovationWorkshop #BaselEvent

We're excited to share the results of our recent collaboration with Beiersdorf in a paper, "Increasing Accessibility of Bayesian Network-Based Defined Approaches for Skin Sensitisation Potency Assessment."  Here we report on how Bayesian Network models have been applied to defined approaches for use in risk assessment. These models were then incorporated into our #SaferSkin application, allowing users to compare the outcomes of different defined approaches and Integrated Approaches to Testing and Assessment (#IATAs). See the full paper here: https://lnkd.in/dqYeQXgE Try the SaferSkin Sensitisation Application: https://lnkd.in/gwM_XU-q #RiskAssessment #Skin #SkinSafety #Innovation #InSilico #InVitro #NAMs

We invite you to join our upcoming webinar, where invited speakers Georgia Reynolds (Unilever), Camilla Taxvig (Lundbeck), and Marie Tintin (Cargill) along with experts from SenzaGen, will share insights on the latest advancements in skin sensitization testing. Register here: https://lnkd.in/djEknbTk If you missed SenzaGen’s scientific presentations at EUROTOX Congress this year, this webinar is your chance to catch up on the most recent developments. Join us to explore the latest data from our GARD® platform on skin sensitization and gain insights from leading industry experts. In addition, we will highlight our latest collaborative projects with industry partners, including L'Oréal and EXXONMOBIL BIOMEDICAL SCIENCES, INC. The webinar will last around 50 minutes, followed by a live Q&A. If you cannot attend the live event, make sure to register to get access to the recording. Key topics *Difficult-to-Test Samples *UVCBs and Formulated Lubricant Products *Drug products and Active Substances *Point-of-Departure for Quantitative Risk Assessment *Defined Approaches *Industry collaborations: Case studies and publications Don’t miss out on this opportunity to gain valuable insights and network with experts in the field! Register here: https://lnkd.in/djEknbTk

We’re in Copenhagen for #EUROTOX 2024! Join us Tuesday at noon local time as we present two posters. We’re excited to share how our digital tools can support your toxicology research and help with regulatory compliance. Let’s connect and find the right fit for your needs! Posters we’re presenting: (P19-45): Data management for image-based characterization of 2D nano-materials (P19-66): Industrial Case Studies in Product Design and Chemical Risk Assessment We’d love to chat—come by, say hello, and let’s explore how we can work together! #Toxicology #DataManagement #RiskAssessment #NAMs #ChemicalSafety #ProductDesign

Did you miss our recent #SaferWorldbyDesign webinar on Streamlining Regulatory Compliance for Cosmetics? Watch the recording here: #CosmeticsSafety #MoCRA #RegulatoryCompliance #RiskAssessment #CosmeticsIndustry #SmartSafety #FDARegulations #FormulationManagement https://lnkd.in/gWJSvq-9

Did you miss our #SaferWorldbyDesign "Smart Safety" webinar? Watch the replay now! Navigating the complexities of #cosmetic safety and new regulations like the FDA's MoCRA is no small feat. Watch to learn how new tools can streamline your regulatory processes and hear from experts on some of the latest #riskassessment and #datamanagement insights for the industry. Panel: Ramez Labib, Barry Hardy, Reena Sandhu View the recording here: https://lnkd.in/g4fuQQFe #CosmeticSafety #SmartSafety #RegulatoryCompliance #MoCRA #IndustryInsights #formulations

🎣 🐟 🐠 🐟 🐠 🐟 🎣 Explore the balance between the benefits of fish consumption and the risks from #PFAS contaminants. Learn about the latest epidemiology studies and how they inform safe consumption guidelines. Presented by: Ali Hamade PhD, DABT #PFAS #PublicHealth #SaferWorldbyDesign #FoodSafety 📺 Watch here: https://lnkd.in/grW8ebR6