Spirochrome

🚀 New Episode Alert! 🚀 FluoSphera & Spirochrome: Episode 2 🎥 We are thrilled to share the next chapter in our series with Spirochrome! In this episode, we demonstrate the selective binding of trastuzumab within co-cultured cancer spheroids, combined with the precision of PKmem probes. Our real-time imaging over five hours beautifully captures the progressive binding of trastuzumab-FITC to targeted cancer cells. 🧪 This experiment represents a major milestone in leveraging multiplexed 3D cell culture systems for oncology research. It allows us to closely mimic and study the complexities of tumor microenvironments, pushing us closer to transforming drug discovery with greater precision and confidence. Spirochrome’s advanced probes demonstrate their exceptional compatibility with our systems, enabling unmatched observation and insights into cellular processes. Congratulations to our incredible team and partners for making this achievement a reality! 💡 Stay tuned for Episode 3! 🎬 #Oncology #3DCellCulture #DrugDiscovery #FluoSphera #Innovation #Biotech #Spirochrome #PKmem #ACCESSGeneva

Looking for fluorescent live imaging probes? 🔬 Spirochrome is a Swiss company developing and manufacturing a range of probes for live cell imaging - with a particular focus on high resolution imaging methods. Spirochrome probes display excellent cell permeability, extremely low background and high photostability, making them a superior solution for extended and high resolution live cell imaging. Discover fluorescent live imaging probes for imaging of 🔹 Plasma membranes 👉 https://lnkd.in/e2ZVw6SU 🔹 Peroxisomes 👉 https://lnkd.in/ewBRmpK2 🔹 Mitochondria 👉 https://lnkd.in/eMY_pQmG 🔹 Dynamic actin labeling 👉 https://lnkd.in/eFJ28vvk Learn more about Spirochrome here 👉 https://lnkd.in/eRaShdYu

Beautiful Peroxisomes and Mitochondria for #SuperResTuesday! Our Peroxi_SPY probes label peroxisomes in live cells with high specificity in only 15 minutes! Product link: https://lnkd.in/e8D6_HFY Image taken on a CSR Biotech MI-SIM 🔬

🚨Spirochrome and FluoSphera new collaboration! Our PKmem probes for gentle plasma membrane imaging meet FluoSphera's highly innovative encapsulated cancer spheroids technology! Staining lasted over 72 hours without (photo)toxicity or bleaching, improving overall data quality and facilitating tissue barcoding/segmentation! A perfect match between the two technologies. 😍Mini-supernovas💥under the objective! More 🤯images and data soon 😉

Hey, it's #FluorescenceFriday! CSR Biotech has been using our probes with their MI-SIM microscope and the results are 😍! The resolution is really impressive. This live cell was labeled with PKmito Orange (magenta), SiR-lysosome (green) and hoechst (blue). Thanks to GenVivo Biotech for leading the initiative here! #imaging #microscopy #LifeSciences

💥 Explosive News! FluoSphera & Spirochrome: Episode 1 🎥 At FluoSphera, we are thrilled to integrate the innovative PKmem probes from Spirochrome into our encapsulated cancer spheroids, taking our tissue color-coding palette to a whole new level. The result is astonishing—like spheroid supernovas! 🌟 Spirochrome’s advanced probes offer exceptional compatibility with our systems, allowing for precise visualization 🔬 for over 72 hours, without any toxicity or photobleaching, ensuring optimal observation of cellular processes. With the PKmem probes, we achieve improved imaging quality 📈 and deeper insights into the dynamic interactions within our 3D cultures, pushing the boundaries of what's possible in drug discovery. Stay tuned for Episode 2 next week! 🎬 #drugdiscovery #fluorescence #microscopy #cellculture #spheroids #3d #imaging #bioimaging #confocal #collaboration #partnership #cancer #oncology

The popular Halotag ligand SiR-CA (or SiR-Halo) is available! SiR-CA is highly cell permeable, extremely well suited for STED nanoscopy and fluorogenic. It is ideally suited for live cell imaging and has been extensively used and validated in the literature. It is now available from Spirochrome! Product link: https://lnkd.in/epNFZTq2 Movie from the article by Bottanelli et al."Two-colour live-cell nanoscale imaging of intracellular targets" ER (Halo-Sec61β labeled with SiR-CA, magenta) and mitochondria (SNAP-OMP25 labeled with 590-BG, green)

Our new Halotag substrate SPY505-CA (also known as MaP510-Halo) is one of the very few green channel Halotag ligands that combines all these properties: High brightness High signal/background ratio (18-fold), Fast labeling kinetics in cells (30 min @ 250 nM) STED compatibility at 595 nm depletion SPY505-CA link: https://lnkd.in/eyM4NsZw Images extracted from the article by Wang, et al.; “A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy”; Nature Chemistry 12, 165-172, 2020.

📢New SPY-Golgi probes! We are thrilled to introduce two innovative probes for live-cell imaging of the Golgi apparatus: SPY650-Golgi and SPY555-Golgi. Link: https://lnkd.in/eSP5G7QR These probes label the Golgi apparatus in live cells within minutes and remain stable through fixation, offering researchers maximum versatility in their experiments. SPY650-golgi is highly STED compatible. Both probes are inspired by the the research article by Saidbakhrom Saidjalolov, PhD from Stefan Matile's lab “Asparagusic Golgi Trackers”.

📢🔥We are really excited to introduce six new HaloTag™ ligands. ➡️ Five fluorogenic, cell-permeable ChloroAlkane (CA) ligands that span the visible spectrum featuring SiR and SPY™ fluorophores. Ideal for STED imaging! ➡️ Halo-Flipper a localizable Flipper-TR membrane tension probe using Halotag as a precise subcellular localization handle. ➡️CA_TestKit is a new kit that combines SPY505-CA, SPY555-CA and SiR-CA in a single product, offering a cost efficient solution to screen for the best ligand to label halotag expressing cells. Visit our website for more information on each product: https://lnkd.in/ebxU_JHx