📚 PUBLICATION | Pediatric soft-tissue #sarcoma screening in our #Gri3D 600µm microwells
⚡️ Exciting News from SUN bioscience!
Our innovative #Gri3D plate takes center stage in groundbreaking research conducted by a collaborative team led by Marie Castets and Laura BROUTIER from Centre Léon Bérard, INSERM, Institut Curie, ADLIN Science, CNRS, and Doppl SA. The teams demonstrated the transformative potential of patient-derived #organoids for ex-vivo drug testing in highly heterogeneous fusion-negative #Rhabdomyosarcoma (FNRMS), a critical pediatric soft-tissue #sarcoma.
#Gri3D 600 µm microwells played a pivotal role in miniaturizing the drug screening process, allowing simultaneous #screening on 55 spheres per #RMS #organoid line and per dose of each therapeutic compound, providing a more efficient and high-throughput approach 🔬.
The study successfully established stable and expandable FNRMS-derived organoids, overcoming previous #challenges in deriving efficient models with the original tumors' molecular specificities in 3D. These organoids were screened using #Gri3D technology using an image-based high-content assay which enabled simultaneous screening of multiple spheres. These findings underscore FNRMS-derived organoids as powerful tools for drug screening, offering insights into therapeutic responses and resistance prediction. The proof-of-concept approach, focused on apoptosis targeting, opens avenues for innovative drug combinations.
At SUN bioscience, we are proud to contribute to advancing research and therapy design through our #Gri3D technology. We look forward to continuing collaborations that push the boundaries of scientific discovery and contribute to improving patient outcomes.
📑 Find the full paper here: https://lnkd.in/dqNEnD3y and contact us at enquiries@sunbioscience.ch to discuss about it! And feel free to contact us if you want to know more (enquiries@sunbioscience.ch).
#drugscreening #organoidtechnology #researchinnovation #paper #Gri3Dplate #oncology