Exploration of Immunology

📢Newly Cited Paper Sharing: High avidity of vaccine-induced immunoglobulin G against SARS-CoV-2: potential relevance for protective humoral immunity #immunity #review #winner 👥 Author: Georg Bauer 🔑 Keywords: Humoral immune response, avidity, severe acute respiratory syndrome coronavirus 2, protective immunity 🎯 "...his approach fades out critical competition reactions between IgG and ACE for RBD of the S1. Quantitative avidity determination might be an essential tool to define individuals that only possess suboptimal protective immunity after vaccination and therefore might benefit from an additional booster immunization." 👤 Academic editor: Wangxue Chen, National Research Council Canada, Canada 🥇 This paper is also one of our 2023 Highly Cited Paper Award winners #research 🔗 Read the full article: https://lnkd.in/g4jvhU6s

📢Newly Published Paper Sharing: Durability of SARS-CoV-2 IgG response: a cross-sectional study in vaccinated healthcare workers using dried blood spot and multi-antigen profiling #OA 👥 Authors: Imam Nurjaya, Erwin Arief, Nur Ahmad Tabri, Irawaty Djaharuddin, Bulkis Natsir, Sitti Nurisyah, Joko Hendarto, Ansariadi Ansariadi, Rasiha Rasiha, Moh. Anfasa Giffari Makkaraka 🔑 Keywords: SARS-CoV-2, vaccine, immunoglobulin G, healthcare worker #COVID #vaccine #IgG 🎯 "Aim: Assessing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies among healthcare workers (HCWs) is crucial in understanding the durability of humoral immune response due to vaccination and the post-pandemic era. Therefore, this study aimed to evaluate IgG antibody seroprevalence, IgG levels, and long-term durability responses after the coronavirus disease 2019 (COVID-19) pandemic in HCWs." 👤 Academic editor: Wenping Gong, The Eighth Medical Center of PLA General Hospital, China 🔗 Read the full article: https://lnkd.in/gMs5Pi4R

📢Newly Published Paper Sharing: Primary biliary cholangitis, a rising health burden #review 👥 Authors: Mohamed Bassyouny Aboueleinin Elnaggar, Ismail Elkhattib (Ismail ELkhattib), Ahmed Abdelsatar Ali Abomhya, James Lorenzen Boyer 🔑 Keywords: Primary biliary cholangitis, cholestasis, liver cirrhosis, GLOBE score, antimitochondrial antibody, management challenges #PBC #liver 🎯 "Primary biliary cholangitis (PBC) is a rare immune-mediated disease, commonly affecting women in their 40s, and ultimately progressing to liver failure. The incidence and prevalence of the disease are increasing worldwide, possibly due to better diagnostic tools. This review will focus on its epidemiology, pathophysiology, diagnosis, prognosis, and new developments in therapy." 👤 Academic editor: Jochen Mattner, FAU Erlangen-Nürnberg and UKER, Germany 🔗 Read the full article: https://lnkd.in/g9f2Y5ai

🔥 Newly & HOT Paper Sharing: Mechanism of formation and significance of antimitochondrial autoantibodies in the pathogenesis of primary biliary cholangitis #review 👥 Authors: Vasiliy Ivanovich Reshetnyak, Igor Veniaminovich Maev 🔑 Keywords: Primary biliary cholangitis, #cholestasis, antimitochondrial autoantibodies, dihydrolipoyl transacetylase of pyruvate dehydrogenase complex, biliary epithelial cells #PBC 🎯 "Primary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease associated with cholangiopathies. The detection of antimitochondrial autoantibodies (AMAs) plays an important role in the diagnosis of classical PBC..." 👤 Academic editor: Margherita Sisto, University of Bari Medical School, Italy 🔗 Read the full article: https://lnkd.in/gpxWQ7wR

📢Newly Published Paper Sharing: Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus #review 👥 Authors: VParnian Fakour, Ata Shirizadeh, Ahmad Tahamoli-Roudsari, Ghasem Solgi 🔑 Keywords: Epigenetic, #FOXP3, #miRNA, #LncRNAs, regulatory T cells, #SLE 🎯 "...Moreover, targeting these epigenetic pathways may offer novel therapeutic strategies for restoring immune balance and ameliorating autoimmune pathology. This review report aimed to provide an update on the epigenetic controlling of FOXP3 gene expression in SLE disease." 👤 Academic editor: Nitin Saksena, Victoria University, Australia 🔗 Read the full article: https://lnkd.in/gj-vjS43

📢Newly Published Paper Sharing: Mechanism of formation and significance of antimitochondrial autoantibodies in the pathogenesis of primary biliary cholangitis #review 👥 Authors: Vasiliy Ivanovich Reshetnyak, Igor Veniaminovich Maev 🔑 Keywords: Primary biliary cholangitis, #cholestasis, antimitochondrial autoantibodies, dihydrolipoyl transacetylase of pyruvate dehydrogenase complex, biliary epithelial cells #PBC 🎯 "Primary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease associated with cholangiopathies. The detection of antimitochondrial autoantibodies (AMAs) plays an important role in the diagnosis of classical PBC..." 👤 Academic editor: Margherita Sisto, University of Bari Medical School, Italy 🔗 Read the full article: https://lnkd.in/gpxWQ7wR

📢Newly Published Paper Sharing: Long-chain noncoding RNA NEAT1 and autoimmune diseases #minireview #RNA 👥 Authors: Cheng Bao, Li-Li Tian, Xiao-Liu Li, Min Xu, Hong-Wei Chen 🔑 Keywords: Nuclear paraspeckle assembly transcript 1, #autoimmune disease, systemic #lupus erythematosus 🎯 "Autoimmune diseases result from the immune system’s response to autoantigen components, leading to damage to one’s own tissues and organs. The correlation between long noncoding RNAs (lncRNAs) and autoimmune diseases remains inconclusive. However, recent studies have revealed that the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays a vital role in the development of various autoimmune diseases. Here, this review briefly summarizes the progress in understanding NEAT1 expression variations and related mechanisms in different autoimmune diseases, and discusses its potential use for future therapeutic applications." 👤 Academic editor: Sofia Kossida, The International ImMunoGeneTics Information System, France 🔗 Read the full article: https://lnkd.in/g-uGsCi4

📢Newly Published Paper Sharing: The future of complement therapeutics 👥 Authors: Martin Kolev (Martin Kolev), Kollu Nageswara Rao, Michael Yeh, Atman Parikh, Pascal Deschatelets  🔑 Keywords: #Complement, complement-mediated disease, complement therapeutics, #gene therapy 🎯 "...In this review, we will discuss the timeline of the academic discoveries that led to the development of the current crop of FDA-approved complement therapeutics. We follow with a discussion of an increasingly crowded complement therapy space and of the scientific advances that have emerged in recent two decades underpinning future innovation, including advances in our understanding of complement biology, such as local and intracellular complement, emerging complement targets, combinational approaches of complement and non-complement therapeutics to unlock new disease indications and new technologies such as gene therapy. We will also give a comprehensive overview of the gene therapy landscape and how it can be utilized to target complement dysregulation." 👤 Academic editor: Uday Kishore, Brunel University London, United Kingdom 🔗 Read the full article: https://lnkd.in/gPx7fzjX

📢Daily Paper Sharing: Herpes simplex virus-mediated skin infections: cytokines and its interplay 👥 Authors: Aparna Mukhopadhyay, Subhashis Indra, Joyeta Ghosh, Saptarshi Biswas, Partha Palit, Debprasad Chattopadhyay 🔑 Keywords: #Skindiseases, herpes simplex virus, #cytokines, #immune activation and evasion 🎯 "...This review will highlight virus-mediated skin infections, especially by HSV, and portray a detailed role of virus-induced cytokines in host-immunity to challenge the invading virion during mucocutaneous HSV infection. Further, this review will discuss the viral-interference on host defense to provide a simplistic overview of the complications of cutaneous HSV infection." 👤 Academic editor: Jochen Mattner, FAU Erlangen-Nürnberg and UKER, Germany 🔗 Read the full article: https://lnkd.in/gaw4raFN

📢Daily Paper Sharing: Safety and tolerability of anti-FcRn monoclonal antibody in thyroid autoimmunity 👥 Authors: Jan Wolf, Irene Krämer, George J. Kahaly 🔑 Keywords: Anti-FcRn monoclonal #antibody, #drug safety, adverse events, side effects, thyroid #autoimmunity 🎯 "...The clinical symptoms of autoantibody (AAb)-mediated autoimmune diseases (AID) usually correlate with the AAb-titer. Immunoglobulins (Igs) of the IgG type are actively recycled by the neonatal crystallizable fragment receptor (FcRn). The most common Ig type of AAb is IgG. This explorative study evaluates the safety and tolerability of a fully human anti-FcRn monoclonal antibody (mAb) in patients with thyroid autoimmunity (TA)." 👤 Academic editor: Roberto Paganelli, G. d’Annunzio University, Italy 🔗 Read the full article: https://lnkd.in/gxWhcyYM