Exploration of Immunology

🎯 As Professor Emeritus at the University of Palermo (Italy), Professor Caruso is a renowned scholar in the field of immunology in aging, with a strong track record of research and publications. 💪 In his new role, Professor Caruso will be responsible for overseeing the peer review process, ensuring the quality and integrity of the journal's content, and working closely with the editorial board to shape the direction of EI. He will also be tasked with expanding the journal's reach and visibility in the scientific community. 🔖 "As the title of this editorial and as a development plan for the coming years during which the journal will be under my leadership, I have chosen 'Immunology Through the Ages', inspired by the title of the 2024 International Day of Immunology webinar, "Immunity Through the Ages: Navigating the Science of Ageing and Immunology", introduced in Prof. Caruso's editorial. 🔥 Please join us in congratulating Professor Caruso on his appointment and wishing him all the best in his new role. We look forward to seeing the exciting developments that will unfold under his leadership. 👏 👏 #Leadership #Immunology #ResearchExcellence #LongevityScience #AcademicPublishing 👉 Read Prof, Caruso's editorial to get more: https://lnkd.in/de6KW4qE

🌟 Announcement 🌟 #NEWS We are proud to welcome Prof. Calogero Caruso as the new Editor-in-Chief of our journal! With an esteemed career in Immunology of Ageing and Longevity, Prof. Caruso’s leadership will play a pivotal role in driving our journal’s mission forward. His deep expertise and vision will help shape the future of research in this rapidly evolving field. We look forward to an exciting new chapter under his guidance. Welcome aboard, Prof. Caruso! #Leadership #Immunology #ResearchExcellence #LongevityScience #AcademicPublishing

📢Newly Published Paper Sharing: Research progress on NLRP3 inflammasomes in male reproductive immunity 👥 Authors: Xue Zhang, Xinyi Dong, Yafei Kang, Xiaohang Liu , Chengchang Zhang, Jiaxin Zhang, Shuting Chen, Donghui Huang 🔑 Keywords: #NLRP3, #inflammasomes, androgenic immunity, #male infertility 🎯 "...In bacterial orchitis, elevated levels of NLRP3 inflammasomes exacerbate the testicular inflammatory injury and lead to decreased testosterone, thus contributing to male infertility. In autoimmune orchitis, the NLRP3 inflammasomes inhibit testosterone synthesis by decreasing the expression of cytochrome P450, thereby impacting male reproductive function. Therefore, targeting NLRP3 could offer novel immunological strategies for the clinical treatment of male infertility." 🔸 Academic editor: Daishu Han, Chinese Academy of Medical Sciences & Peking Union Medical College, China Link: https://lnkd.in/g9pZC_94

📢Newly Published Paper Sharing: Critical role of keratinocytes in cutaneous immune responses 👥 Authors: Kalthoum Abid, Jihene Bettaieb, Faouzi El Mezni, Hamouda Boussen 🗝 Keywords: Xeroderma pigmentosum, #skin carcinomas, DNA damage, cytokines, radiotherapy, #chemotherapy, #inflammation 🎯 "... In this study, we demonstrate a general tendency to secrete inflammatory cytokines, in the cancerous groups of patients (XP and non-XP), in comparison to healthy controls, while a significantly higher propensity to develop inflammation, in XP than in non-XP cancer patients." 👤 Academic Editor: Narinder K. Mehra, Indian Council of Medical Research (ICMR), India 🔗 Read the full article: https://lnkd.in/gAwpJ8SM

📢Newly Published Paper Sharing: Evolving role of immunology in chronic pain medicine: tissue necrosis factor and interleukin modulatory treatments #pain #TNF #immunotherapy 👥 Authors: Rucha A. Kelkar, Alan D. Kaye, Dominique M. Perilloux, Alison M. Hawkins, Grace C. Wester, Amanda R. Ragland, Sage V. Hebert, Sahar Shekoohi, Giustino Varrassi 🗝 Keywords: Cytokine modulation, chronic pain, TNF inhibitors, interleukin modulation, immunotherapy 🎯 "...Secukinumab and tocilizumab serve as IL inhibitors, utilized for a similar purpose. These novel immunotherapies have shown efficacy in numerous clinical studies with acceptable side effect profiles. In this review, we summarize the pharmacological profiles of these drugs and discuss their usage in treating chronic pain." 👤 Academic Editor: Giuseppe Bardi, Istituto Italiano di Tecnologia, Italy 🔗 Read the full article: https://lnkd.in/g5A4k3w6

📢Newly Published Paper Sharing: Advances in rationally engineered cytokines for precision therapy in diabetic wound healing #diabetic #wound 👥 Authors: Xinxin Zhang, Tingting Wang, Xiangqing Fan, Tianze Zhang, Rui Qiu, Yuqi Wu, Meixia Wang, Yizhi Zhang, Meng Li, Na Cai , Ying Guan, Hong-Hui Wang 🔑 Keywords: Cytokine engineering, diabetic wound healing, precision therapy, synthetic biology, rationally designed cytokines, molecular modifications 🎯 "...This review not only provides valuable perspectives on the future research directions but also offers insights into the potential clinical applications of these innovative therapies, aiming to significantly improve the outcomes for patients suffering from diabetic wounds." 👤 Academic Editor: Dominique J. Charron, Hospital Saint Louis, France 🔗 Read the full article: https://lnkd.in/gpBpk8VY

📢Newly Published Paper Sharing: Exploring the impact of immune response on tumor heterogeneity through mathematical modeling 👥 Authors: Diksha Gautam, Sanjeev Kumar, Rashmi Sharma, Deepshikha Dixit 🔑 Keywords: Mathematical modeling, #tumor heterogeneity, immune response, reaction-diffusion model, clonal expansion, #mutation, therapeutic strategies 🎯 "...Our findings show that a stronger immune response leads to greater homogeneity in the tumor population, which suggests that enhancing immune response could reduce tumor heterogeneity and improve treatment outcomes." 🔗 Read the full article: https://lnkd.in/gARrWXw6

📢Newly Published Paper Sharing: Research progress on NLRP3 inflammasomes in male reproductive immunity 👥 Authors: Xue Zhang, Xinyi Dong, Yafei Kang, Xiaohang Liu , Chengchang Zhang, Jiaxin Zhang, Shuting Chen, Donghui Huang 🔑 Keywords: #NLRP3, #inflammasomes, androgenic immunity, #male infertility 🎯 "...In bacterial orchitis, elevated levels of NLRP3 inflammasomes exacerbate the testicular inflammatory injury and lead to decreased testosterone, thus contributing to male infertility. In autoimmune orchitis, the NLRP3 inflammasomes inhibit testosterone synthesis by decreasing the expression of cytochrome P450, thereby impacting male reproductive function. Therefore, targeting NLRP3 could offer novel immunological strategies for the clinical treatment of male infertility." 🔸 Academic editor: Daishu Han, Chinese Academy of Medical Sciences & Peking Union Medical College, China 🔗 Read the full article: https://lnkd.in/g9pZC_94

📢Newly Published Paper Sharing: IL-6 signaling pathway differentiation for endometriosis and inflammatory diseases 👥 Authors: Ryan D. Castle (Ryan Castle) 🔑 Keywords: #Inflammation, interleukin-6, #endometriosis, #cytokines, #biomarkers, inflammatory diseases 🎯 "...This review proposes adjustments to research methodologies and stresses the importance of careful interpretation of inflammatory markers in IL-6-related research. Examples of differentiation issues are discussed across the topics of endometriosis and multiple inflammatory diseases. By addressing this methodological issue, researchers could potentially improve patient outcomes, enhance the efficacy of interventions, and contribute to public health advancements." 🔸 Academic editor: Giustino Varrassi 🔗 Read the full article: https://lnkd.in/gVFJgTAe

📢Newly Published Paper Sharing: Assessment of non-classical lymphocyte populations in patients with advanced lung cancer treated with Biomodulina T following platinum-based chemotherapy #cancer 👥 Authors: Gisela María Suárez, Mauricio Catalá, Yadira Peña, Susana Portela, Ana Laura Añé-Kourí, Amnely González, Patricia Lorenzo-Luaces, Manuel Díaz, María de los A. Molina, Karla Pereira, Jenysbel de la C. Hernández, Mary Carmen Reyes, Nuris Ledón, Zaima Mazorra, Tania Crombet, Agustin Lage, Antonio Bencomo-Hernandez, Danay Saavedra 🔑 Keywords: Natural killer, natural killer T cells, double-positive T lymphocytes, non-small cell lung cancer, #CD57, Biomodulina T, #chemotherapy 🎯 "...These results suggest a lower influence of platinum-based chemotherapy on non-classical lymphocytes and the potential to generate a reconstitution of lymphocyte subpopulations in patients with advanced lung cancer by using the thymic factor BT, which reveals a new possibility for improving the response to cancer immunotherapies." 🔗 Read the full article: https://lnkd.in/gbkX2DfJ