WuXi Discovery Services

Cereblon (CRBN) forms an E3 ligase complex together with DDB1, CUL4, and RBX1. CRBN functions as a substrate receptor of this complex, and this protein is a key target for the action of small molecules. Targeting of CRBN can modify its substrate specificity towards non-physiological proteins, which are subsequently ubiquitinated and degraded by the proteasome. To support the discovery of CRBN-DDB1 PROTACs® and molecular glues, WuXi AppTec offers a comprehensive platform of ready-to-go biophysical assays, high-quality protein production, and established X-ray crystallography protocols. Click ⬇️ to learn more https://lnkd.in/eWnypVwe #Biophysical #Crystallography #StructuralBiology #nanoDSF #MST #CRBN #E3Ligase #DDB1 #PROTAC #MolecularGlues

Would you like to predict organic reaction outcomes accurately and design synthetic sequences with higher rates of success? Would you prefer to learn and rationalize organic chemistry in a data-driven manner? Quantum mechanics (QM) tools for chemistry are evolving at a tremendously fast pace and have proven to be invaluable for organic and medicinal chemists. We are excited to announce that the latest edition of our QM eBook, “Quantum Mechanics for Organic Chemists, An Experimentalist Approach” is now available! Click👇this link to request a copy of our 4th edition eBook: https://lnkd.in/g9DYGeZU #QM #QuantumChemistry #MedicinalChemistry #OrganicChemistry #RCS #ResearchChemistryServices #DiscoveryChemistry #SpecialtyChemistry

Through the strategy of induced proximity, monovalent and heterobifunctional molecules enable the drugging of an increasingly wide range of challenging therapeutic targets. Join WuXi AppTec at the 7th Annual TPD & Induced Proximity Summit, covering the latest advancements in proximity-induced targeted protein degradation (TPD). Since 2016, WuXi AppTec has built a comprehensive TPD discovery service platform to investigate the full functional cycle of protein degraders - from binary/ternary complex formation to target ubiquitination and degradation. Don’t miss our talk entitled: "DEL Facilitates the Discovery of TPD Molecules" and our poster, "Integrated PROteolysis TArgeting Chimeras (PROTACs) Drug Discovery Platform". Click 👇 this link to prearrange a dedicated meeting: https://lnkd.in/gw7NGbGD #InducedProximity #TPD #PROTAC #ProteinDegraders #MolecularGlues #LYTAC #DUBTAC

One of the biggest challenges in early drug discovery is finding selective binders for drug targets. In recent publication in ACS Medicinal Chemistry Letters, Our WuXi AppTec DEL team tackled this by combining DNA-Encoded Library (DEL) technology with Machine Learning (ML) on Heme Oxygenase-1 (HO-1), an enzyme sharing high similarity with its counter target HO-2. We discovered five series of HO-1 hits with >100x selectivity over HO-2 and novel scaffolds, expanding beyond the DEL chemical space. This work expanded the capability of DEL+ML method to selectivity problem, opening new doors for selective hits finding by ML approach. It also paves the way for HO-1 inhibitors development and thus targeting HO-1 related diseases like cancer and neurodegenerative disorders. Click here for the full text: https://lnkd.in/dirVcFbX #DrugDiscovery #DEL #MachineLearning #MedicinalChemistry #Selectivity #HemeOxygenase-1

🌐 Discover where WuXi Discovery Services is headed next! Our Global Events Page keeps you up-to-date on upcoming conferences, specialized workshops, and more. Join us to dive into breakthroughs in drug discovery and engage with our experts who are passionate about advancing your work. We can’t wait to connect and collaborate! 👉 Explore upcoming events here: https://lnkd.in/eEZqAY2K

The hepatobiliary system (comprised of the liver, gallbladder, and bile ducts) plays an important role in digestion and in the biotransformation and disposition of endogenous molecules and drugs. Hepatobiliary diseases range from minor infection or scarring to serious conditions such as cancer. To support research in this area, WuXi AppTec provides a comprehensive platform of hepatobiliary-related services, such as our CAP-certified pathology laboratory and our extensive panel of animal disease models, including NAFLD, fibrosis, cirrhosis, and a clinically-relevant NASH mouse model. Click 👇 this link to learn more: https://lnkd.in/e5XKVjdJ #Hepatobiliary #LiverDisease #NAFLD #LiverFibrosis #Cirrhosis #NASH

WuXi AppTec offers a comprehensive platform of in silico drug discovery services to accelerate the process of hit finding and hit-to-lead optimization. We provide access to virtual chemical spaces built from our library of novel drug-like scaffolds, to support structure-based virtual screening (SBVS). Advances in ML-empowered virtual screening allow project teams to examine a rapidly expanding and diverse chemical space for discovering new molecules. By combining experimental data (from techniques such as DEL and ASMS) with computational predictions, our experts can deliver results with enhanced predictivity. Click this link 👇 to view our workflow and case studies: https://lnkd.in/gPPnADNg #DrugDiscovery #InSilico #ADME #DEL #ASMS #SBVS #Screening

There's still time to register for our upcoming webinar! With advancements in drug design, there is resurging interest in drugs that form covalent bonds with their targets, often referred to as targeted covalent inhibitors (TCIs). Covalent drugs have the potential to provide enhanced potency and prolonged duration of action compared to non-covalent drugs. In this webinar, our experts will discuss innovative approaches to screen for covalent binders, strategies for the synthesis of covalent warheads, and assays to optimize the ADME/DMPK properties of these molecules. Don’t miss your chance to ask questions to our experts! Register today by clicking 👇 this link: https://lnkd.in/eKfRcfkY #DrugDiscovery #Biotech #Covalent #CovalentBinding #TCI

Despite the excellent clinical response to paclitaxel therapy, drug resistance inevitably develops in subsequent treatments. The mechanisms for resistance to paclitaxel include drug efflux transporter overexpression, altered apoptotic gene expression, and changes associated with microtubules to reduce the influence of this chemotherapeutic agent. The development of targeted therapies for overcoming paclitaxel resistance represents an unmet medical need. To support research in this area, WuXi AppTec has established gastric cancer and breast cancer paclitaxel-resistant tumor models. Click this link 👇 to learn more: https://lnkd.in/eRmVHv_W #DrugDiscovery #DrugResistance #Paclitaxel #Oncology #Antitumor #Taxane #Taxol

As part of our neurobiology services platform, WuXi AppTec offers a comprehensive panel of advanced technologies and validated disease models to help project teams overcome the challenges in predicting the efficacy and safety of their lead candidates. We provide a full spectrum of neurological coverage, from neurodegenerative diseases and neuropsychiatric disorders to sensory and rare disorders. Our in-depth analytics allows researchers to harness the insights of behavioral and neurophysiological assessments for a data-driven approach to drug discovery. Click👇the link below to view our case studies, including the application of a clinical biomarker in a mouse model for Alzheimer’s. https://lnkd.in/ed4m8KQk #DrugDiscovery #CNS #Neurobiology #Neurodegenerative #Neurosensory