Cube Biotech

𝗪𝗲'𝗿𝗲 𝘁𝗵𝗿𝗶𝗹𝗹𝗲𝗱 𝘁𝗼 𝗽𝗮𝗿𝘁𝗶𝗰𝗶𝗽𝗮𝘁𝗲 𝗶𝗻 𝘁𝗵𝗲 𝟯𝟴𝘁𝗵 𝗔𝗻𝗻𝘂𝗮𝗹 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝗼𝗳 𝗧𝗵𝗲 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗦𝗼𝗰𝗶𝗲𝘁𝘆 𝗶𝗻 𝗩𝗮𝗻𝗰𝗼𝘂𝘃𝗲𝗿, 𝗖𝗮𝗻𝗮𝗱𝗮! Don't miss the chance to meet with Dr. Philipp T. Hanisch and Michael Ries, who are eager to discuss the latest advancements in protein science and how Cube Biotech can support your research endeavors. 𝗪𝗲 𝘄𝗼𝘂𝗹𝗱 𝗹𝗼𝘃𝗲 𝘁𝗼 𝘁𝗮𝗹𝗸 𝘁𝗼 𝘆𝗼𝘂 𝗮𝗯𝗼𝘂𝘁 𝘁𝗵𝗲 𝗹𝗮𝘁𝗲𝘀𝘁 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀 𝗼𝗳 𝗺𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘀𝘁𝗮𝗯𝗶𝗹𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗽𝘂𝗿𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻! Join us to exchange ideas and share knowledge! #proteinsociety #copolymer #nativemp #cubebiotech #MembraneProteins #Biotech

☀️ August is just around the corner and that means vacation time! For all those who are still busy on the road, we have prepared a new masterclass for you: Elissa Moller from the The National Institutes of Health & University of Maryland is going to join us for the next class. Elissa will present findings and insights of the mechanosensitive channel MscS, how important protein-lipid interactions are for its gating cycle, and what helped her in extracting the channel from its membrane environment. Save August 1st in your calendars to learn about her workflows, how to troubleshoot, and what else is happening in structural biology. Register here ➡ https://lnkd.in/db3FcTG6 #pioneeringtogether #nih #cryoem #copolymers #mechanosensation

𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝘁𝗵𝗲 𝗖𝘂𝗯𝗶𝗽𝗼𝗹 𝗦𝗲𝗿𝗶𝗲𝘀 𝗮𝗻𝗱 𝗗𝗜𝗕𝗠𝗔 𝟲: 𝗥𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗶𝘇𝗲 𝗬𝗼𝘂𝗿 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘄𝗶𝘁𝗵 𝘁𝗵𝗲 𝗡𝗮𝘁𝗶𝘃𝗲𝗠𝗣™ 𝗣𝗹𝗮𝘁𝗳𝗼𝗿𝗺 𝖥𝗈𝗅𝗅𝗈𝗐𝗂𝗇𝗀 𝗈𝗎𝗋 𝗋𝖾𝖼𝖾𝗇𝗍 𝖻𝗋𝖾𝖺𝗄𝗍𝗁𝗋𝗈𝗎𝗀𝗁 𝗂𝗇 𝗌𝗈𝗅𝗏𝗂𝗇𝗀 𝗍𝗁𝖾 𝖿𝗂𝗋𝗌𝗍 𝗌𝗍𝗋𝗎𝖼𝗍𝗎𝗋𝖾 𝗈𝖿 𝗍𝗁𝖾 '𝗁𝗎𝗆𝖺𝗇' 𝖯𝟤𝖷𝟦 𝗆𝖾𝗆𝖻𝗋𝖺𝗇𝖾 𝗉𝗋𝗈𝗍𝖾𝗂𝗇 𝗏𝗂𝖺 𝖼𝗋𝗒𝗈-𝖤𝖬, 𝗐𝖾'𝗋𝖾 𝖾𝗑𝖼𝗂𝗍𝖾𝖽 𝗍𝗈 𝗂𝗇𝗍𝗋𝗈𝖽𝗎𝖼𝖾 𝗆𝗈𝗋𝖾 𝗂𝗇𝗇𝗈𝗏𝖺𝗍𝗂𝗈𝗇𝗌 𝗍𝗈 𝗈𝗎𝗋 𝖭𝖺𝗍𝗂𝗏𝖾𝖬𝖯™ 𝖯𝗅𝖺𝗍𝖿𝗈𝗋𝗆. 𝖮𝗎𝗋 𝗌𝗎𝖼𝖼𝖾𝗌𝗌 𝗐𝗂𝗍𝗁 𝗁𝖯𝟤𝖷𝟦, 𝖺 𝖼𝗋𝗎𝖼𝗂𝖺𝗅 𝗉𝗅𝖺𝗒𝖾𝗋 𝗂𝗇 𝗌𝗒𝗇𝖺𝗉𝗍𝗂𝖼 𝗍𝗋𝖺𝗇𝗌𝗆𝗂𝗌𝗌𝗂𝗈𝗇 𝖺𝗇𝖽 𝗂𝗇𝖿𝗅𝖺𝗆𝗆𝖺𝗍𝗂𝗈𝗇, 𝗐𝖺𝗌 𝖺𝖼𝗁𝗂𝖾𝗏𝖾𝖽 𝗎𝗌𝗂𝗇𝗀 𝗈𝗎𝗋 𝗇𝖾𝗐𝖾𝗌𝗍 𝖼𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋, 𝖲𝗎𝗅𝖿𝗈-𝖢𝗎𝖻𝗂𝗉𝗈𝗅 𝖿𝗋𝗈𝗆 𝗍𝗁𝖾 𝖢𝗎𝖻𝗂𝗉𝗈𝗅 𝖢𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋 𝖲𝖾𝗋𝗂𝖾𝗌. 𝖳𝗈𝖽𝖺𝗒, 𝗐𝖾 𝖺𝗋𝖾 𝗉𝗋𝗈𝗎𝖽 𝗍𝗈 𝗉𝗋𝖾𝗌𝖾𝗇𝗍 𝗍𝗁𝖾 𝖼𝗈𝗆𝗉𝗅𝖾𝗍𝖾 Cubipol Copolymer Series and DIBMA 6, 𝗍𝗁𝖾 𝗅𝖺𝗍𝖾𝗌𝗍 𝖺𝖽𝖽𝗂𝗍𝗂𝗈𝗇𝗌 𝗍𝗈 𝗈𝗎𝗋 𝖭𝖾𝗑𝗍 𝖦𝖾𝗇𝖾𝗋𝖺𝗍𝗂𝗈𝗇 𝖢𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋𝗌. 𝖣𝖾𝗏𝖾𝗅𝗈𝗉𝖾𝖽 𝖻𝗒 𝗈𝗎𝗋 𝖾𝗑𝗉𝖾𝗋𝗍𝗌 𝗐𝗂𝗍𝗁 𝗈𝗏𝖾𝗋 𝟣𝟢 𝗒𝖾𝖺𝗋𝗌 𝗈𝖿 𝖾𝗑𝗉𝖾𝗋𝗂𝖾𝗇𝖼𝖾, 𝗍𝗁𝖾𝗌𝖾 𝖼𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋𝗌 𝖼𝗈𝗆𝖻𝗂𝗇𝖾 𝗍𝗁𝖾 𝖻𝖾𝗌𝗍 𝖿𝖾𝖺𝗍𝗎𝗋𝖾𝗌 𝗈𝖿 𝖼𝗅𝖺𝗌𝗌𝗂𝖼 𝖼𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋𝗌 𝗅𝗂𝗄𝖾 𝖲𝖬𝖠 𝗐𝗂𝗍𝗁 𝗍𝗁𝖾 𝖺𝖽𝗏𝖺𝗇𝖼𝖾𝗆𝖾𝗇𝗍𝗌 𝗈𝖿 𝗇𝖾𝗑𝗍-𝗀𝖾𝗇 𝗍𝖾𝖼𝗁𝗇𝗈𝗅𝗈𝗀𝗂𝖾𝗌 𝗌𝗎𝖼𝗁 𝖺𝗌 𝖴𝗅𝗍𝗋𝖺𝗌𝗈𝗅𝗎𝗍𝖾 𝖠𝗆𝗉𝗁𝗂𝗉𝗈𝗅. 𝖳𝗁𝗂𝗌 𝖾𝗑𝗉𝖺𝗇𝖽𝗌 𝗍𝗁𝖾 𝗌𝖼𝗋𝖾𝖾𝗇𝗂𝗇𝗀 𝗉𝗈𝗍𝖾𝗇𝗍𝗂𝖺𝗅 𝗈𝖿 𝗍𝗁𝖾 𝖭𝖺𝗍𝗂𝗏𝖾𝖬𝖯™ 𝖯𝗅𝖺𝗍𝖿𝗈𝗋𝗆 𝖺𝗇𝖽 𝖾𝗇𝗁𝖺𝗇𝖼𝖾𝗌 𝗍𝗁𝖾 𝗌𝗈𝗅𝗎𝖻𝗂𝗅𝗂𝗓𝖺𝗍𝗂𝗈𝗇 𝖺𝗇𝖽 𝗌𝗍𝖺𝖻𝗂𝗅𝗂𝗓𝖺𝗍𝗂𝗈𝗇 𝗈𝖿 𝗆𝖾𝗆𝖻𝗋𝖺𝗇𝖾 𝗉𝗋𝗈𝗍𝖾𝗂𝗇𝗌. 🌟 𝗪𝗶𝘁𝗵 𝘁𝗵𝗲 𝗡𝗮𝘁𝗶𝘃𝗲𝗠𝗣 𝗣𝗹𝗮𝘁𝗳𝗼𝗿𝗺, 𝘄𝗵𝗮𝘁 𝗽𝗿𝗲𝘃𝗶𝗼𝘂𝘀𝗹𝘆 𝘁𝗼𝗼𝗸 𝗺𝗮𝗻𝘆 𝘆𝗲𝗮𝗿𝘀 𝘁𝗼 𝘀𝗼𝗹𝘃𝗲, 𝗮 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗲 𝗰𝗮𝗻 𝗻𝗼𝘄 𝗯𝗲 𝗮𝗰𝗰𝗼𝗺𝗽𝗹𝗶𝘀𝗵𝗲𝗱 𝗶𝗻 𝗷𝘂𝘀𝘁 𝟮 𝗺𝗼𝗻𝘁𝗵𝘀! 𝖣𝗂𝗏𝖾 𝗂𝗇𝗍𝗈 𝗍𝗁𝖾 𝖿𝖾𝖺𝗍𝗎𝗋𝖾𝗌 𝗈𝖿 𝗈𝗎𝗋 𝗇𝖾𝗐 𝖼𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋𝗌 𝗈𝗋 𝗌𝖼𝗁𝖾𝖽𝗎𝗅𝖾 𝖺 𝗆𝖾𝖾𝗍𝗂𝗇𝗀 𝗍𝗈 𝖽𝗂𝗌𝖼𝗈𝗏𝖾𝗋 𝗁𝗈𝗐 𝗍𝗁𝖾𝗒 𝖼𝖺𝗇 𝖺𝖼𝖼𝖾𝗅𝖾𝗋𝖺𝗍𝖾 𝗒𝗈𝗎𝗋 𝗋𝖾𝗌𝖾𝖺𝗋𝖼𝗁 𝖺𝗇𝖽 𝗎𝗇𝗅𝗈𝖼𝗄 𝗇𝖾𝗐 𝗉𝗈𝗌𝗌𝗂𝖻𝗂𝗅𝗂𝗍𝗂𝖾𝗌 𝗂𝗇 𝖽𝗋𝗎𝗀 𝖽𝗂𝗌𝖼𝗈𝗏𝖾𝗋𝗒. ◾ 𝖤𝗑𝗉𝗅𝗈𝗋𝖾 𝖯𝗋𝗈𝖽𝗎𝖼𝗍 𝖥𝖾𝖺𝗍𝗎𝗋𝖾𝗌 ➡ https://linktr.ee/cubipols ◾ Schedule a Meeting ➡ https://lnkd.in/eAZu28WC #𝖬𝖾𝗆𝖻𝗋𝖺𝗇𝖾𝖯𝗋𝗈𝗍𝖾𝗂𝗇𝗌 #𝖡𝗂𝗈𝗍𝖾𝖼𝗁𝖨𝗇𝗇𝗈𝗏𝖺𝗍𝗂𝗈𝗇 #𝖣𝗋𝗎𝗀𝖣𝗂𝗌𝖼𝗈𝗏𝖾𝗋𝗒 #𝖢𝗋𝗒𝗈𝖤𝖬 #𝖢𝗎𝖻𝖾𝖡𝗂𝗈𝗍𝖾𝖼𝗁 #𝖭𝖾𝗑𝗍𝖦𝖾𝗇𝖢𝗈𝗉𝗈𝗅𝗒𝗆𝖾𝗋𝗌 #𝖲𝗍𝗋𝗎𝖼𝗍𝗎𝗋𝖺𝗅𝖡𝗂𝗈𝗅𝗈𝗀𝗒 #𝖭𝖺𝗍𝗂𝗏𝖾𝖬𝖯𝖯𝗅𝖺𝗍𝖿𝗈𝗋𝗆

CD163 enters the stage of our membrane protein target pipeline: https://lnkd.in/dZpMeXFW Book a meeting with Barbara or one of our other project managers to hear more about the NativeMP™ Technology Platform and how it enables these fast discoveries: https://lnkd.in/dCKiUXEe #drugdiscovery #cd163 #nativeMP #cubebiotech #membraneprotein

NOW LIVE: Join us to learn more about cell-free expression for the structural and biophysical characterization of complex and challenging proteins and protein complexes with Dr. Alex Snow 🎬

𝗔𝗿𝗲 𝘆𝗼𝘂 𝘂𝘀𝗶𝗻𝗴 Ä𝗸𝘁𝗮 𝗦𝘆𝘀𝘁𝗲𝗺𝘀, 𝗡𝗚𝗖 𝗖𝗵𝗿𝗼𝗺𝗮𝘁𝗼𝗴𝗿𝗮𝗽𝗵𝘆 𝗦𝘆𝘀𝘁𝗲𝗺𝘀, 𝗞𝗶𝗻𝗴𝗙𝗶𝘀𝗵𝗲𝗿 𝗦𝘆𝘀𝘁𝗲𝗺𝘀, 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝗹𝗶𝗾𝘂𝗶𝗱 𝗵𝗮𝗻𝗱𝗹𝗶𝗻𝗴 𝘀𝘆𝘀𝘁𝗲𝗺𝘀, 𝗼𝗿 𝗯𝗮𝘁𝗰𝗵 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 𝗳𝗼𝗿 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗽𝘂𝗿𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻? Here's how to optimize your histidine-tagged protein purification process: 𝗢𝘄𝗶𝗻𝗴 𝘁𝗼 𝗶𝘁𝘀 𝘂𝗻𝗶𝗾𝘂𝗲 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴, 𝗣𝘂𝗿𝗲𝗖𝘂𝗯𝗲 𝗡𝗶-𝗡𝗧𝗔 𝗔𝗴𝗮𝗿𝗼𝘀𝗲 𝗼𝗳𝗳𝗲𝗿𝘀 𝗮 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗯𝗶𝗻𝗱𝗶𝗻𝗴 𝗰𝗮𝗽𝗮𝗰𝗶𝘁𝘆 𝘂𝗽 𝘁𝗼 𝟯𝟲% 𝗵𝗶𝗴𝗵𝗲𝗿 𝘁𝗵𝗮𝗻 𝗡𝗶-𝗡𝗧𝗔 𝗿𝗲𝘀𝗶𝗻 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝘀 𝗼𝗳 𝘁𝗵𝗿𝗲𝗲 𝗹𝗲𝗮𝗱𝗶𝗻𝗴 𝗰𝗼𝗺𝗽𝗲𝘁𝗶𝘁𝗼𝗿𝘀, 𝘄𝗲 𝗿𝗲𝗳𝗲𝗿 𝘁𝗼 𝘁𝗵𝗲𝗺 𝗮𝘀 "𝗔"," 𝗕" 𝗮𝗻𝗱 "𝗖".   In our comparative analysis of Ni-NTA resin products, protein isolation was carried out using E. coli lysate and insect cell lysate in a batch system, as you can see in the figure.  PureCube Ni-NTA Agarose demonstrates superior performance compared to three leading competitor materials, establishing it as the premier Ni-NTA resin currently available. This feedback has already been submitted to us by customers.    Additionally, the resin is designed for long-term reuse, ensuring sustained efficiency over years. 

Even though summer hasn't really arrived in Germany yet, we want to offer you some hot science with Dr. Alex Snow from the University of Leeds. ☀️ Alex Snow will present findings and insights of the application of cell-free expression for the structural and biophysical characterization of complex and challenging proteins and protein complexes. Join us on July 10th to learn about his workflows, how to troubleshoot, and what else is happening in protein research. #pioneeringtogether #leeds #cryoem #cellfree #copolymers

Listen up structural biologists and drug discovery experts! We are thrilled to announce a significant breakthrough at Cube Biotech! Leveraging just one of our newest copolymer inventions in our NativeMP™ Platform, we have successfully obtained the very first structure of the ‘Human’ P2X4 membrane protein in its native membrane environment via cryo-EM. P2X4, a crucial player in synaptic transmission and inflammation, holds significant promise in drug discovery, particularly for developing novel therapies for chronic pain and inflammatory diseases. Traditionally, detergents have been the standard method for stabilizing membrane proteins for cryo-EM. However, they fall short of preserving the protein’s native environment, affecting functional stability and further analysis (Schmidpeter et al., 2022 https://lnkd.in/etCdXuSv; Corradi et al., 2018 https://lnkd.in/eA5K2aHQ). Our Next Generation Copolymers – AASTYs, Ultrasolute™ Amphipols, and our newest invention, Ultrasolute™ Cubipol – address this challenge by stabilizing membrane proteins in their native environment in a single step. This enhances the functional stability of these proteins and makes them suitable for sensitive downstream applications like cryo-EM. Stay tuned for the upcoming launch, where we will unveil the full lineup of the new copolymers joining our Next Generation Copolymers. Get ready to explore how these innovative solutions can revolutionize your research and drug discovery efforts! #CryoEM #MembraneProteins #DrugDiscovery #BiotechInnovation #P2X4 #ScientificBreakthrough #CubeBiotech 

New Week, new potential drug target! This time, our project manager, Dr. Maryna Löwe, presented hERG (Kv11.1). Want to know how our NativeMP™ Technology Platform allows us to stabilize these hot targets so quickly? - Then book yourself a little chat with Maryna or one of our other project managers right here: https://lnkd.in/eMjH3cag #nativemp #drugtarget #cubebiotech #drugdiscovery #herg

𝗖𝗵𝗮𝗹𝗹𝗲𝗻𝗴𝗲 𝗨𝘀 𝘄𝗶𝘁𝗵 𝗬𝗼𝘂𝗿 𝗧𝗮𝗿𝗴𝗲𝘁! Just two weeks ago, we unveiled our highly anticipated Drug Discovery Pipeline, and today, we’re excited to present our first target: FAS, the tumor necrosis factor receptor superfamily member 6. 𝗙𝗔𝗦 forms the death-inducing signaling complex DISC upon ligand binding, can trigger apoptosis, and is associated with cancer. It plays a critical role in the immune system and, therefore, poses a promising target for preclinical studies and assay development. Do you need 10 mg of stabilized FAS protein? Are you interested in the high-resolution cryo-EM structure? Your goal is to generate a therapeutic antibody? Together, we can make it happen. Made in Europe and ready within 4 weeks, our human full-length targets accelerate your journey! Still unsure? Challenge Cube with your hardest target, the one you struggle with the most, and we’ll push your research together! Please contact us to learn more about our unique 𝗡𝗮𝘁𝗶𝘃𝗲𝗠𝗣 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗣𝗹𝗮𝘁𝗳𝗼𝗿𝗺 for any membrane protein class (https://lnkd.in/eAZu28WC) or directly book a meeting with one of our project managers: https://lnkd.in/eMjH3cag. #pioneeringtogether #drugdiscovery #targetpipeline #nativeMP