EMBL

EMBL congratulates David Baker, Demis Hassabis, and John Jumper on the 2024 #NobelPrize in Chemistry for their seminal discoveries and developments on protein structures. While David Baker developed computational methods that can create new proteins, Demis Hassabis and John Jumper helped develop the revolutionary AI tool AlphaFold, which can successfully predict the three-dimensional structure of a protein from a sequence of amino acids. Knowing a protein’s structure offers clues about the protein’s role, its link to health and disease, and its interactions with other molecules or drugs. EMBL partnered with Google DeepMind to make the AlphaFold 2 predictions freely and openly available to all, through the AlphaFold Protein Structure Database. The AlphaFold Database, which launched in July 2021, has a staggering 200 million protein structures, from over one million organisms. AlphaFold demonstrates the virtuous circle of open data – by sharing data, scientists are enabling future discoveries. The Nobel Prize | #chemnobel | #alphafold | Google DeepMind

EMBL’s ARISE summer school brought together fellows from across EMBL sites who are working on technology projects as part of the MSCA-funded ARISE programme. Through five days of presentations and activities, the fellows gained skills and knowledge that could help them in future careers in research infrastructure management. Learn more: https://lnkd.in/emnvshQW

Time to accelerate! ⏱️ Only 1 month left to apply for EMBL ARISE2 fellowship program. Are you interested in the development of new or improvement of existing technologies to support life science research? ARISE2 is a unique programme that trains scientists and engineers for leadership positions in research infrastructures in academia or industry. This includes mentoring and networking, as well as inter-disciplinary and inter-sectoral exposure. Apply now! embl.org/training/arise2/

Employing a library of >1,000 chemicals, EMBL scientists and collaborators investigated effects on insect populations. They found 57% of the chemicals – even in amounts known not to be fatal – altered fruit fly larvae behaviour, and higher percentages compromised long-term survival. These observations were exacerbated when the ambient temperature increased by four degrees. Additionally, an expanded investigation including mosquitoes and butterflies resulted in similar behavioural changes. https://lnkd.in/eMudTHUp Justin Crocker Michael Zimmermann jean-baptiste masson Mikhail Savitski Victoria Ingham Maria Zimmermann-Kogadeeva Christian Tischer Natalia Misunou Noa Ottilie Borst

A new study from researchers at EMBL Heidelberg has brought us one step closer to understanding how a cellular superhero – a protein called TRIM25 – exercises its superpowers to fight viruses. TRIM25 is an important part of our innate immune response against RNA viruses. The new study provides novel insights into its function, potentially helping in the design of new antiviral strategies in the future. https://lnkd.in/e-vVMfxB

It is part of EMBL’s mission to spark a passion for science among young people. A hands-on workshop, organised in collaboration with Native Scientists, offered an excellent opportunity for scientists to connect with children with whom they share a native language. Learn more here: https://lnkd.in/euCfuxMk

EMBL’s first Industry Day was a success, and it won’t be the last! On 14 October, EMBL hosted representatives of 14 leading pharmaceutical and biotech companies for an afternoon of networking and scientific exchange on innovative products, advanced technologies, sustainability plans, and career options. It was an excellent chance for EMBL scientists to meet the providers of their cutting-edge research tools, and learn more about new instruments, greener products, ground-breaking technologies, and job opportunities. Read more here 👉 https://lnkd.in/dR_CKxwC

EMBL scientists have developed a new method – GPMelt – shedding light on previously overlooked proteins with unconventional melting behaviours. This new statistical and computational method augments thermal proteome profiling (TPP), an unbiased proteomics approach developed by Mikhail Savitski, Team Leader at EMBL. Unlike traditional methods focused on sigmoidal curve shapes, GPMelt embraces all melting curve behaviours – no matter how irregular – giving us access to a more comprehensive view of the thermal proteome. By including proteins that were previously excluded from the analysis, GPMelt unlocks new biological discoveries through the exploration of the full complexity of the meltome. The method implementation is available on GitLab: https://lnkd.in/efD9nxAm Read the new paper here: https://lnkd.in/egYjXRNR

EMBL-EBI will be live on LinkedIn to discuss the main steps to increase the impact of open software projects! 👀 This European Bioinformatics Institute | EMBL-EBI panel discussion is perfect for anyone who creates research software and is interested in practical aspects of developing or using open source code. A basic understanding of coding or software development is beneficial. The main steps that will be discussed during the live panel include: - Maintenance - Community building - Discoverability - Project management - Documentation - Licensing - User needs - And much more Find out more and register below  https://lnkd.in/de7qZxyT

EMBL Rome volunteers participated in the European Researchers’ Night organised by the CNR in Montelibretti, attended by over 1,500 visitors! They prepared activities and games reflecting the variety of research projects conducted at the site & across EMBL. https://lnkd.in/dFuAfJnH #EuropeanResearchersNight Consiglio Nazionale delle Ricerche ASSOCIAZIONE ADAMAS SCIENZA