Fraunhofer ITEM

🔬💼 Dr. Gustav Bruer has been head of the department of Inhalation Toxicology at Fraunhofer ITEM since February 2021. What he likes most about his work is its variety, as no two days are the same and every project yields new challenges. His department is financially independent, which means that Gustav cannot exclusively consider science but needs to pay attention to economics as well. He particularly enjoys the great collaboration of his team as well as the exchange with customers and project partners around the world. 🌍 👨🎓 Gustav was particularly influenced by his doctoral supervisor, Professor Kietzmann, who emphasized the importance of finding a truly exciting topic to work on. This passion and dedication enables Gustav to achieve great things without his daily work feeling like a burden. 🏆 Gustav is especially proud of the current nanoparticle project, as this project demonstrates how small details in research can lead to big changes, right up to the global application or elimination of substances. 📚 Besides his job’s main tasks, Gustav values the advice and support of mentors and colleagues he gets from mutual exchange. This exchange has not only fostered his professional development but has also led to great, non-work-related friendships. 🚗 If he’s not working, Gustav loves to spend time with his car. The sound of the engines, the whistling of the turbochargers and the roar of the exhaust make him feel alive and help him kick back. For him, a successful day consists of a balance between productivity and relaxation, according to the motto ‘Business before pleasure’. 🔗 Read Gustav’s full portrait on our careers page: https://lnkd.in/eTdfNa4D #yourITEMjob #inhalationtoxicity

#newpublication: Exciting News from our “Personalized Tumor Therapy” department! We are happy to announce that our manuscript titled "Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients" has just been published online! 🌐👉https://lnkd.in/ew2zg7YE In this study, we explored the potential of cellular liquid biopsy (cLB) as a precision oncology tool, specifically for patients with rare salivary gland cancers. Our findings reveal the significant role of cLB and tumoroids as a preclinical model in disease monitoring and personalized treatment strategies. A special thanks to our dedicated team from Fraunhofer ITEM and the Universitätsklinikum Regensburg: Christian Werno, Natasa Stojanovic Guzvic, Florian Lüke, Prof. Dr. med. Tobias Pukrop, Kamran Honarnejad, Christoph Klein, Bernhard Polzer, Steffi Treitschke, Andrea Coluccio, PhD, Martin Hoffmann, Giancarlo Feliciello, Dr. Adithi Varadarajan, Catherine Botteron. We would also like to extend our gratitude to the patients and their families for their invaluable participation, as well as to the physicians for their great cooperation 🙏 . If you are interested in #translationalresearch on #LiquidBiopsy and ex vivo drug screening, please also check our webpage: 🌐👉https://lnkd.in/gthp_TZF   #oncology #tumorresearch #precisionmedicine #tumoroids

👉➕The great advantage of in-silico methods is that they allow for simulating toxicological effects of untested compounds. Thus, they enable the minimization of animal testing as well as saving time and costs. ▶️Our hands-on training course “In-silico-toxicology” will introduce the participants to different in-silico approaches for estimation of human health toxicological endpoints, namely QSAR models, read-across, and the TTC (threshold of toxicological concern) concept. The relevance of the predicted results depends on several aspects like the accuracy of the model, the quality of the data on which the model is trained and its applicability domain. Our training course will address these aspects, and also provide 🔎 insights in: What in-silico models do already exist? When and how are they applied? What approaches are there to evaluate and integrate the sometimes contradictory predictions? Furthermore, the training will also outline the basic principles of physiologically based kinetic (PBK) modeling. The course is intended for attendees with little or moderate experience in in-silico-methods. 📅Date: December 3, 2024, 1:30 p.m., to December 5, 2024, 2:00 p.m. 📍Location: Fraunhofer ITEM, Hannover (DE) Sounds interesting? Places are available upon a first-come, first serve basis. Registration will close as soon as the maximum number of participants is reached, on October 31, 2024, at the latest. 👉More information on the training course, registration, registration fees…can be found on our website: 🔗 https://lnkd.in/e-Xvxtbu We look forward to welcoming you in December!🙂 #insilicomethods #insilico

On Friday, 25 October 2024, the 2nd European Commission Conference on the Roadmap to Phasing Out Animal Testing for Chemical Safety Assessments will take place in Brussels and online. The event will provide an update on the progress made so far and offer another valuable opportunity for discussion with Member States and key stakeholders. We are proud to share that Sylvia. Escher from Fraunhofer ITEM will be presenting an "Update from ASPIS on the ASPA Workflow" as part of the session on NAM (New Approach Methodologies) roadmaps. In addition, during a satellite meeting this evening, various case studies from the RISK-HUNT3R project and #ASPA will be showcased. Sylvia will present on “A Prioritisation and Screening Approach to Discriminate Toxic from Low-Toxic Chemicals.” 🙋♀️ #ASPA stands for the Safety Profiling Algorithm initiated by the #ASPIScluster. 🙋♀️The RISK-HUNT3R project is funded by the EU's #Horizon2020 Research and Innovation programme and is part of the ASPIS cluster. 🤩💪We are excited and proud to be part of the ASPIS cluster, contributing our expertise to advancing Next-Generation Risk Assessment (NGRA) and supporting the transition towards non-animal methods in chemical safety assessment. #chemicalsafety #safetyassessment #NAMs #NGRA

Werde Teil unseres Teams als #MTA (Medizinisch-Technische*r Assistent*in) für Funktionsdiagnostik! Du suchst nicht nur eine neue berufliche Herausforderung, sondern auch ein Umfeld, in dem echte Teamarbeit zählt? In unserem Video zeigen wir dir, wer wir sind und was uns in der Klinischen Atemwegsforschung am Fraunhofer ITEM antreibt. Wir sind ein motiviertes Team, das mit Herzblut und Spaß an der Arbeit täglich neue Herausforderungen meistert – und jetzt suchen wir DICH! Schau rein und erlebe, wie wir zusammenarbeiten und warum du bei uns genau richtig bist 😀 . Wir freuen uns auf deine Verstärkung! 🔗 Zur Stellenausschreibung: https://lnkd.in/evY76JVE #yourITEMjob #pioneersforsustainablehealth

Werde Teil unseres Teams als #MTA (Medizinisch-Technische*r Assistent*in) für Funktionsdiagnostik! Du suchst nicht nur eine neue berufliche Herausforderung, sondern auch ein Umfeld, in dem echte Teamarbeit zählt? In unserem Video zeigen wir dir, wer wir sind und was uns in der Klinischen Atemwegsforschung am Fraunhofer ITEM antreibt. Wir sind ein motiviertes Team, das mit Herzblut und Spaß an der Arbeit täglich neue Herausforderungen meistert – und jetzt suchen wir DICH! Schau rein und erlebe, wie wir zusammenarbeiten und warum du bei uns genau richtig bist 😀 . Wir freuen uns auf deine Verstärkung! 🔗 Zur Stellenausschreibung: https://lnkd.in/evY76JVE #yourITEMjob #pioneersforsustainablehealth

🏆 The use of immune-related Adverse Outcome Pathways (#irAOPs) within the 3R concept, developed through the imSAVAR project, is again gaining attention! This innovative approach was presented by Charline Sommer at the #3R symposium in Saarbrücken last week, reflecting the growing interest in reducing animal testing while improving the safety of immune therapies. 💡 IrAOPs help to pinpoint key cells and molecules responsible for immune therapy side effects, revealing critical gaps in our understanding of the immune response. Within the imSAVAR project, we use irAOPs to design targeted experiments that address these knowledge gaps. The results do not only verify and expand the irAOPs but also aim to contribute to improving drug safety in clinical settings. #immunetherapies #safetytesting #3R

Dr.-Ing. Ute Urban and Kianusch Pour Rahimi would be delighted to meet you at the #DKOU in Berlin!

🦠🔍 Du hast Lust, neben deinem Studium spannende Laborerfahrung zu sammeln und Einblicke in die Infektions- und Immunforschung zu gewinnen?   🫁🔬 Wenn du darüber hinaus zeitlich flexibel und bereit bist, mit humanem Gewebe (Lunge, Leber und Darm) zu arbeiten, dann freut sich unser Team der Arbeitsgruppe »Infektion und Immunologie« auf deine Unterstützung bei der Bearbeitung von humanem Lungen-, Leber- oder Darmmaterial. 🧪🧫 In dieser Position unterstützt du als Studentische Hilfskraft unter anderem bei der Herstellung von humanen Gewebeschnitten sowie der Durchführung standardisierter Waschvorgänge und erhältst dabei spannende Einblicke in die Forschungsarbeit an unserem Institut. Hier zum Stellenausschreibung: https://lnkd.in/e_qRujxB Weitere aktuelle Jobangebote des Fraunhofer ITEM: - Mitarbeiter*in im Personalmanagement: https://lnkd.in/eKN3G6Tg - Finanzcontroller*in: https://lnkd.in/eZBrBDH5 - Ausbildung zum*zur Fachangestellten für Medien- und Informationsdienste - Medizinische Dokumentation: https://lnkd.in/ens462WW 💼💡Du möchtest mehr über das Arbeiten am Fraunhofer ITEM erfahren? Dann informiere dich auf unserer Karriereseite: https://lnkd.in/e--Gz9Ax #veränderungstartetmituns #jobsinresearch #jobs #studentenjobs #infektionsforschung #immunologie #forschung #research #hannover #yourITEMjob

🔬 Investigating the Safety of Trace Element Products for Biogas Plants Using Biological Tests 🔬 The updated Technical Rule for Hazardous Substances 529 (TRGS 529) now allows the use of cobalt and nickel compounds in biogas plants without special safety measures – provided that biological tests demonstrate no activation of cancer-causing mechanisms. At Fraunhofer ITEM, Tanja Hansen and her team have developed human-relevant biological tests to assess the bioavailability of these heavy metal compounds. Their findings reveal that, under physiological conditions, the tested compounds are not bioavailable in humans and are thus toxicologically safe 🌱. This testing approach has the potential to address similar questions for other trace elements, contributing to both safety and efficiency in biogas production. 👉 Learn more about our research and commitment to safe handling of hazardous substances on our website. #safetyassessment #toxicologytesting #biogasplants