GeSiM Gesellschaft fuer Silizium-Mikrosysteme mbH

To celebrate the World Hearing Day we want to share with you the process of manufacturing a synthetic tympanic membrane (TM) to tackle large TM perforations caused by chronic otitis media. 🦻 This innovative approach mimics the fibrous structure and morphology of the TM, resulting in similar acousto-mechanical properties. Its high biocompatibility supports the migration of keratinocytes and fibroblasts to form a neo-epithelial layer. This groundbreaking TM replacement was achieved through three advanced additive manufacturing processes. Watch the video to see how this synthetic alternative could transform the lives of millions suffering from chronic middle ear infections. 📝 Read the Article behind this innovation: https://lnkd.in/epbasrAj Special thanks to the Centre for Translational Bone, Joint and Soft Tissue Research for their incredible work. 🌟 #RegenerativeMedicine #AdditiveManufacturing #TissueEngineering #WorldHearingDay Max von Witzleben | Marcus Neudert | Tilman von Strauwitz | Matthias Bornitz | Anne Bernhardt | Prof. Michael Gelinsky

This year, we proudly celebrate 𝟯𝟬 𝘆𝗲𝗮𝗿𝘀 𝗼𝗳 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗲𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝗰𝗲 in the bioinstrumentation industry. For three decades, we’ve been at the forefront, transforming science through cutting-edge technology and continuous improvement. 🚀 🎥 We’re excited to feature a previously unseen technique in our anniversary: watch our spray tool reveal the scaffold, bringing it to life. #30YearsOfInnovation #bioinstrumentation #microfluidics #Innovation

The pharmaceutical industry has been revolutionized by the advent of 3D printing technologies, celebrated for their potential to produce personalized, cost-effective, and intricate oral dosage forms. Since the FDA’s approval of the first 3D-printed tablet, the interest in printable drug formulations has grown immensely. This momentum has inspired groundbreaking research into innovative methods for creating precise and adaptable drug delivery systems. A study done by researchers at the Universidade Federal de Juiz de Fora and the University of Greenwich combined Fused Deposition Modeling (FDM) and inkjet printing to develop 3D-printed, drug-loaded tablets designed for personalized medicine. This approach aims to improve precision, reproducibility, and adaptability in pharmaceutical manufacturing, marking a significant step toward tailored healthcare solutions. If you'd like to dive deeper into this fascinating research and its potential impact, please read the full article on our website here: https://lnkd.in/egysR82m Additionally, don't miss the opportunity to watch a video showcasing the innovative scaffold loading technique here: https://lnkd.in/eRybJRP5 #3Dprinting #pharmaceuticals #precisionmedicine Laura Junqueira | Urias Vaz | MARCOS ANTONIO FERNANDES BRANDÃO | Dennis Douroumis | Nádia Rezende Barbosa Raposo

Researchers from the Sapienza Università di Roma, Istituto Italiano di Tecnologia and Fraunhofer IOF developed a direct competitive assay for detecting HER2, a key biomarker in breast cancer, using Bloch surface wave-based biosensors. Researchers utilized a one-dimensional photonic crystal (1DPC) optimized for the visible spectrum, enabling both label-free and fluorescence detection modes. This innovative approach allowed real-time monitoring of HER2 levels in human plasma, achieving rapid and cost-effective results within 20 minutes. Our high-precision non-contact microarray printer, the Nano-Plotter, was instrumental for the bioassay protocol. It facilitated the nano-plotting of the HER2 biomarker solution onto the biochip’s chemically functionalized surface with remarkable accuracy (25 μm) and controlled droplet volume (650 pL per drop), ensuring precise immobilization crucial for the assay's success. This work represents a significant advancement in cancer diagnostics, offering a faster, more efficient alternative to traditional methods. By combining label-free and fluorescence detection, the assay not only enhances diagnostic accuracy but also holds potential for therapeutic monitoring, paving the way for improved patient outcomes in breast cancer care. 📄 Curious to learn more? Dive deeper into their methods and results on our website: https://lnkd.in/e_MQip3u #nanotechnology #Biosensors #BreastCancerAwareness #HealthTech Tommaso Pileri | Alberto Sinibaldi | Norbert Danz | Matteo Allegretti | Frank Sonntag | Patrizio Giacomini | Francesco Michelotti

✨ 30 years of innovation, expertise, and commitment. ✨ We take pride in not just meeting but exceeding our customers’ needs, as well as the ever-evolving demands of the industry. It’s incredibly rewarding to see the impact our BioScaffolder has on groundbreaking research! A huge thank you to our amazing customer for sharing this thoughtful review: 🎯 “The adaptability of the print heads is definitely one of my favorite features.” Here’s to celebrating many more years of collaboration, customization, and success! 🥂 If you want to learn more about their research: Programmable DNA-crosslinked hydrogel for tissue engineering: https://lnkd.in/e2cxiDrd #TissueEngineering #nanotechnology #Innovation Yu-Hsuan Peng | Syuan Ku Hsiao | Krishna Gupta, PhD | André Ruland | Günter K. Auernhammer | Manfred Maitz | Susanne Boye | Johanna Lattner | Elisha Krieg | Claudia Gerri | Carsten Werner

Cartilage tissue has low self-repair capability and lesions often progress irreversibly. Extrusion bioprinting of constructs loaded with stem cell spheroids, offers valuable alternatives for research and therapy. Human mesenchymal stromal cell (hMSC) spheroids differentiate faster and more efficiently than single cells, enabling rapid, controlled, and reproducible larger tissue creation. However, challenges remain in controlling tissue architecture, construct stability, and cell viability during maturation. To address these challenges, researchers from the MERLN Institute for Technology-Inspired Regenerative Medicine focused on bioprinting hMSC spheroids encapsulated in a xanthan gum-alginate hydrogel, followed by a post-bioprinting chondrogenic differentiation procedure. The BioScaffolder facilitated the precise and reproducible bioprinting of 4-layered, 1 × 1 cm constructs with uniform interfilament spacing. It enabled the use of a nozzle suitable for spheroid-loaded bioinks, ensuring low shear stress, and maintaining the stability and viability of the bioprinted constructs. This research presents a promising procedure for obtaining 3D models for cartilage research and potential use as stable chondral tissue implants. The ability to chondrogenically differentiate hMSC spheroids faster and more efficiently than single cells offers valuable alternatives for cartilage tissue engineering. 📄 Find out more about the detailed results and methodology: https://lnkd.in/e9M45MEM #RegenerativeMedicine #TissueEngineering #Cartilage Monize Caiado Decarli | Adrián Seijas-Gamardo | Francis Morgan | Paul Wieringa | Matthew Baker | Jorge Vicente Lopes da Silva | Lorenzo Moroni | Carlos Miguel Domingues Mota

As we approach our 30th anniversary, we want to celebrate and share the remarkable research our customers have achieved using the BioScaffolder. We're proud to provide machines that help our customers achieve their goals and are thrilled to receive such positive feedback. This review highlights the innovative work done with our technology, which is the result of many years of dedication and effort. We're grateful for the opportunity to support your research and look forward to many more years of collaboration and success. 🙌 📑 If you want to learn more about their research: -Wound-healing hydrogel constructs: https://lnkd.in/eS7YjrVG -Multifunctional hydrogel BTE scaffolds: https://lnkd.in/eSxuM7Vt -Osteogenic nanocomposite scaffolds: https://lnkd.in/ezANwsjR #regenerativemedicine #TissueEngineering #3Dbioprinting Mahshid Monavari | Shahin Homaeigohar | Miguel Fuentes Chandia | Dr.-Ing. Qaisar Nawaz | Mehran Monavari | Prof. Aldo R. Boccaccini

Researchers from the Shanghai Jiao Tong University School of Medicine have developed an innovative hydrogel using a blend of silk fibroin and gelatin, designed for effective healing of infected wounds. This hydrogel is photo-crosslinked to enhance its structural integrity and incorporates MOF-methylene blue nanoparticles. These nanoparticles, when activated by light, produce reactive oxygen species that effectively kill bacteria, providing a dual function of supporting tissue regeneration and fighting infections. The BioScaffolder 3.2 was used in a low-temperature bioprinting modality. The high-precision printing capabilities allowed the researchers to accurately deposit the silk fibroin–gelatin hydrogel, creating customizable structures for wound dressings. This research is significant as it addresses the global challenge of treating infected wounds. By offering a promising alternative to traditional antibiotic treatments, this hydrogel can reduce reliance on antibiotics and help combat antibiotic resistance. The integration of advanced materials and 3D-bioprinting technology opens new avenues for personalized and effective wound care solutions. #regenerativemedicine #3Dbioprinting #TissueEngineering 📄 Find out more about the detailed results and methodology: https://lnkd.in/gn5wQ7K5

Prevent Blindness has again declared February as Age-related Macular Degeneration (AMD) and Low Vision Awareness Month. In honor of this, we are highlighting research that offers new alternatives for those affected by vision impairments. Visual impairment and blindness are significant global issues, especially with the rise in diabetic retinopathy (DR) and age-related macular degeneration (AMD) cases. Traditional treatments like costly intravitreal injections pose accessibility challenges. Researchers from Queen's University Belfast, Universitas Airlangga, and Universidad de Sevilla have developed promising axitinib-loaded polymeric implants to address the challenge of current treatments which are expensive and therefore, limit the access to healthcare. These implants can sustain drug release for up to 180 days, offering a safer and more effective alternative. Curious to learn more? Dive deeper into their methods and results on our website: https://lnkd.in/etA_Hpf6 #regenerativemedicine #3Dbioprinting #BlindnessPrevention #HealthcareInnovation Febri Annuryanti | Masoud Adhami | Ubah Abdi | Juan Domínguez Robles | Eneko Larrañeta | Raghu Raj Singh Thakur

Letzte Woche haben wir uns im Verbundprojekt „Messsystem mit plasmonischem Sensor für die Vor-Ort-Analyse der E. coli-Belastung für die Wasserwiederverwendung (Ecoplas)“ zum Kick-off beim Koordinator ECH Elektrochemie Halle GmbH getroffen. In Ecoplas wird eine Online-Analytik zur direkten Erfassung von E. coli-Konzentrationen und deren Zellviabilität (intakte bzw. geschädigte Zellmembran) in der Wasseraufbereitung entwickelt und unter praxisnahen Bedingungen erprobt. Die dafür verfolgte Sensoriklösung vom Fraunhofer IKTS basiert auf einer Antikörper-funktionalisierten, plasmonischen Nanostruktur. Dieser Biosensorchip wird von ECH Elektrochemie Halle GmbH in einem Online-Messsystem mit einer automatischen Fluidsteuerung von GeSiM Gesellschaft fuer Silizium-Mikrosysteme mbH und einer robusten, miniaturisierten Signalerfassung von dresden elektronik ingenieurtechnik gmbh integriert. Die Funktion des Messystems wird vom Institut für Hygiene und Public Health/Uniklinik Bonn mit dem Kultur-Goldstandard verglichen. Im Projekt wird das Messsystem zur ressourcenschonenden und bedarfsgerechten Regelung einer Anlage zur Wasserdesinfektion von Xylem Water Solutions Herford GmbH beim Abwasserverband Braunschweig, zum Gewässermonitoring bei Emschergenossenschaft / Lippeverband und Emscher Wassertechnik / Lippe Wassertechnik (EWLW) erprobt. Das ISOE – Institut für sozial-ökologische Forschung begleitet Entwicklung und Test des Messsystems mit Anwenderdialogen. Damit leistet das Projekt einen wichtigen Beitrag sowohl zum Schutz der knapper werdenden Ressource „Wasser“ durch eine gut überwachbare landwirtschaftliche Wasserwiederverwendung als auch zur Einsparung von Energie und Chemikalien im Aufbereitungsprozess. Ecoplas wird vom Bundesministerium für Bildung und Forschung gefördert und vom VDI Technologiezentrum GmbH betreut.