Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut

Our Pharmaceutical Microbiology and Biomolecular Chemistry researchers, together with scientists from Friedrich-Schiller-Universität Jena, have discovered a hidden #toxin in some 🍄 #mushrooms that only develops its effect after fungal cells are destroyed during preparation. It is a form of the already known #muscarine - the 4'-phosphomuscarine. The research results have now been published in the journal Angewandte Chemie International Edition. They could help #doctors and #toxicologists to better assess the actual danger of certain types of #fungi and treat #poisoning more efficiently. ChemBioSys Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation 👉 click here for the publication https://lnkd.in/dwWiy7PG 👉 and also have a look at our press release https://lnkd.in/d8VcMAxk Christian Hertweck Benjamin Bartels Felix Trottmann #LeibnizHKI #AcetylcholineReceptor #PhosphateEster #FungalResearch

Despite the increasing number of opportunistic fungal infections, treatments remain limited. Thus, our focus is on understanding fungal pathogenicity and antifungal immunity through new #LiveCellAnalysis. With the new live-cell imaging system #LifeFunPath, we can study and visualize host-pathogen interactions in real-time. This helps us understand these dynamic processes. The new system allows us to: - Track interactions between fungi and human cells over 24 hours, - Monitor cell death and the impact of molecules inhibiting fungal toxins, - Test more samples than ever before with a high-throughput capacity of up to six 96-well plates simultaneously. Unique features include: - Microscope positioned within an incubator for stable cell conditions. - Minimization of cell damage by filtering out cell-toxic blue light. - Prevention of biological process interference by maneuvering the microscope objective instead of moving the plates. Life-cell analysis will enable us to gain better insights into the immunology of fungal infections, and therefore advances our search for targets for host-directed treatment of severe fungal infections. Find more information here: https://lnkd.in/exrPyiqs The project, which was funded by the Free State of Thuringia, was co-financed by the European Union as part of the European Regional Development Fund (ERDF). Thüringer Aufbaubank Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation European Union

Researchers at our Bio Pilot Plant study microorganisms in their native context, as co-cultures living together. They aim to find novel bioactive compounds which are vital for the treatment of resistant pathogens. Yet, challenges persist in cultivating stable co-cultures under laboratory conditions. The Bio Pilot Plant pioneers multiscale cultivation systems to bridge the gap between basic research and real-world applications. Crucially, our quest for stable co-cultures demands innovative measurement technologies. Therefore, we’re proud of our advanced #CoKuPro equipment infrastructure, including: ➡️ Next-Generation Shaking Incubators: Tailored for seamless integration with existing cultivation systems, these state-of-the-art incubators facilitate real-time monitoring of microbial growth. ➡️ 2D Fluorescence Spectrometers: These imaging spectrometers facilitate our ability to track the formation of key substances within co-cultures and offer great insights into microbial interactions. Thus, they accelerate the discovery of potent bioactive agents. The project, supported by the Free State of Thuringia, was co-financed by funds from the European Union as part of the European Regional Development Fund (ERDF). Thüringer Aufbaubank European Union

Are you interested in understanding the importance of early engagement with unique regulatory bodies? Here is a great webinar opportunity to fight #AMR from INCATE for you! 📅 19th November 🕔 5 pm CET Sign up here ➡️ https://lnkd.in/e_c54PzZ

📽💡 Watch the MDR MITTELDEUTSCHER RUNDFUNK feature with Christina Zielinski and her research group about how tumor cells can be influenced by salt – 🔎 outside of the body! 👀 See the report in German beginning at minute 17:24. 👉 https://lnkd.in/dMBAfrxK 📖 ... And if you fancy getting to know all the scientific details, you can also find the original Nature Portfolio publication here: https://lnkd.in/g3MMqHV4 Thanks to our research partners: Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut, Friedrich-Schiller-Universität Jena, Universitätsklinikum Jena, Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI), Technische Universität München, Technische Universität Braunschweig, Universität Freiburg, Universitätsklinikum Freiburg, Helmholtz Munich, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Universitätsklinikum Würzburg, Medizinische Universität Wien and Philipps Universität Marburg 🙌 Funding: Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation Balance of the Microverse, Bundesministerium für Bildung und Forschung, Carl-Zeiss-Stiftung and Leibniz Center for Photonics in Infection Research 🙌 #Salt #CommonSalt #NaCl #SodiumChloride #Cancer #ImmunoTherapy #CancerResearch #CancerTherapy #TCellTherapy #MedicalResearch #LeibnizHKI

Research on Endosymbiosis in fungi Researchers from Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut Balance of the Microverse and ETH Zürich explored how bacteria can establish endosymbiotic relationships within fungal cells. Their recent study, published in Nature Magazine, reveals how bacteria like Mycetohabitans rhizoxinica can successfully integrate into fungi, even entering their spores to ensure transmission to future generations. This interdisciplinary research enhances the knowledge of microbial partnerships and also opens up exciting opportunities for biotechnological applications. These could range from using bacteria-fungi symbioses to protect crops from disease, to engineering fungi for the production of pharmaceuticals and enzymes. #Endosymbiosis #Biotechnology #Microbiology #Fungi #Research #Innovation #Natur #UniJena #ChemBioSys_jen #Funbiosis2017 👉 recent press release https://lnkd.in/dPup4UHg 👉 Full Publication https://lnkd.in/d_X3axhZ

As I only recently joined LinkedIn, I haven't shared this here yet: I will start a junior research group at Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut next year! 🤩   We will investigate (antimicrobial) natural products from the moss microbiome - a promising but so far understudied habitat. 🌱 🔄 🦠   Two PhD and a postdoc position are available! Come join me if you are excited about natural product discovery, genome mining, and metabolomics – and want to understand the roles of secondary metabolites in ecological interactions! 🧪🖥️🧬🧫   ➡️ PhD: https://lnkd.in/dg2DaSzV   ➡️ Postdoc: https://lnkd.in/drbuv9yd   Funded by Thüringer Ministerium für Wirtschaft, Wissenschaft & Digitale Gesellschaft, Europäischer Sozialfonds (ESF) Plus, Thüringer Aufbaubank 🙏

New international MSCA project "MiCCrobioTAckle" starts! A team led by Gianni Panagiotou, professor of Microbiome Dynamics in the Balance of the Microverse, is investigating the role of the gut microbiome in tumor cachexia and developing innovative treatment approaches to find ways to slow down muscle wasting. The project involves 24 scientific and industrial partners from 12 countries. 12 doctoral candidates will be trained across Europe over the next 4 years to advance microbiota medicine. The hope is to be able to transfer the findings of the project to other metabolic diseases such as diabetes or obesity in the future. #Microbiome #Cancer #Research 🚀 👉 https://lnkd.in/dQqd-9-C

🎊 We are celebrating 10 Years of Fungal Research at NRZMyk in Jena and Würzburg! 🔬🍄 This year, the National Reference Center for Invasive Fungal Infections, #NRZMyk, at LeibnizHKI marks a decade of excellence in aiding doctors across Germany in diagnosing and treating life-threatening fungal infections. From just 79 patient samples in 2014 to over 1,300 annually today, the NRZMyk has become an essential service, saving countless lives through its specialized expertise in #fungi. 🏥 At #LeibnizHKI, we’re proud to host this center together with our partners from the @Julius-Maximilians-Universität Würzburg. It plays a key role in advancing medical mycology by: · identifying rare and dangerous fungal pathogens, · guiding treatment options to improve patient outcomes 💉, and · supporting doctors with critical diagnostic assistance across Germany. Over the years, NRZMyk has also contributed to crucial national and international research, including tracking the spread of the multidrug-resistant pathogen Candida auris. Here’s to many more years of advancing fungal infection research and protecting public health! 🙌 #HappyAnniversary #Celebration #NationalReferenceCenter #FungalResearch #HealthCare #Mycology #MedicalResearch #FungalDisease #InfectiousDiseases #PathogenResearch #ClinicalDiagnostics #ScientificExcellence

🐉🚣 Fun and sun at the dragon boat race. 🌞 Our team “Leibniz ist kein Butterkeks” had fun paddling the regatta last Saturday on Schleichersee.