Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut

We are happy to join forces with the BLINK AG team on this exciting project to advance detection of antimicrobial resistance!

🥳 We are proud of Harikumar R Suma, who won third place in the Microverse Photo Contest with this excellent image. Well done! #MicroversePhotoContest

📢 A study reveals how targeted modifications at the C-6 position of nitro-benzothiazinones (BTZs) can modify their metabolization propensity towards hydride-Meisenheimer complex (HMC) formation. Reducing HMC formation propensity while retaining potency against #Mycobacterium #tuberculosis on this kind of compounds remains a challenge. The study was conducted by our researchers François KEIFF, Freddy Bernal, Melanie Joch and others from the Transfer Group Anti-infectives, together with researchers from the Friedrich-Schiller-Universität Jena. 🔬 The principal results of the study are … ✔️ Structure-Metabolism Relationships: Substitutions at the C-6 position influence the formation of the Meisenheimer complex, which may facilitate optimal parent drug exposure. ✔️ Multi-Parameter Optimization: Understanding structure-activity and structure-metabolism relationships aids in developing efficacious antimycobacterial BTZs. These findings could pave the way for designing more potent anti-tuberculosis drugs. 🔎📖 Learn more about it via #CommunChem: https://lnkd.in/g7Cysicn 💡 … and read the latest news on the clinical trial phase of BTZ-043 here 👉🏾: https://lnkd.in/g9wr7r8g LMU Klinikum München UNITE4TB Deutsches Zentrum für Infektionsforschung Friedrich-Schiller-Universität Jena HAPILA GmbH Bundesministerium für Bildung und Forschung Thüringer Ministerium für Wirtschaft, Wissenschaft & Digitale Gesellschaft #Antimicrobial #AntiInfectives #DrugDiscovery #MycobacteriumTuberculosis #ChemicalModifications #BTZ #NitroBenzothiazinones #MeisenheimerComplex #DprE1 #ChemInformatics #ComputationalChemistry #MedicinalChemistry #PharmaceuticalResearch #Chemistry #MedicalScience #NewPublication #NewPaper #CommunicationsChemistry #SpringerNature #TransferGroupAntiInfectives #LeibnizHKI

Now on YouTube: #MeetOurScientist Hannah Büttner! A doctoral researcher from Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut. Watch what she has to say about the symbiosis of a fungus and a bacterium which produce a natural product together to protect them! 👇 https://t.co/FgT2YyoUFa

Interview with Bernhard Hube in #BIOspektrum 💡💬 We are pleased to share an interview with Prof. Dr. Bernhard Hube, Head of the Department of Microbial Pathogenicity Mechanisms at Leibniz-HKI, in the latest issue of BIOspektrum. Hube discusses his research on human pathogenic fungi, particularly focusing on #Candida species, and the progress in understanding fungal infections and developing new approaches to address these challenges. 📰 Read the interview in German here: https://lnkd.in/ezaUF697 🗞️… and the corresponding German BIOspektrum article: https://lnkd.in/edgKHUts Balance of the Microverse | Friedrich-Schiller-Universität Jena | Springer Nature Group #Interview #MicrobialPathogenicity #FungalInfections #InfectionBiology #LeibnizHKI

Christian Hertweck has been awarded the prestigious ERC Advanced Grant from the European Research Council (ERC) for #AnoxyGen. 🙌 In this project, Hertweck and his team from the Biomolecular Chemistry department at Leibniz-HKI want to analyze the unique biosynthetic pathways of #anaerobes – organisms that don’t need oxygen to survive. 🔬🦠 By using novel molecular and synthetic biology tools, the researchers aim to decode these pathways, and thus could potentially discover new compounds with various application options in biotechnology, medicine and ecology. The project also contributes significantly to the Cluster of Excellence Balance of the Microverse, which enhances our knowledge of microbial communities and their interactions. Congratulations to Prof. Hertweck and his team! 🔎 Read more about it here: https://lnkd.in/eXYeBNS5 #ERCGrant #Anaerobes #Biotechnology #BiomolecularChemistry #ScienceForFuture #Microverse #BalanceOfTheMicroverse #LeibnizHKI Friedrich-Schiller-Universität Jena

“I always wanted to be a chemistry professor,” says Hajo Kries, the former junior group leader for Biosynthetic Design of Natural Products at our institute. His dream has now finally become true. ✨🌠 On July 1, Kries has been appointed W3 professor of Technical Biochemistry at the Universität Stuttgart. Congratulations! We look forward to possible future collaborations with Professor Hajo Kries, who shows us how important our support for young researchers is. 🦉🎓💡 https://lnkd.in/ewnJ7nEu #Professorship #Congrats #NewProfessor #BioChemistry #Research #Science #University #Stuttgart #YoungResearchers #DreamsComeTrue

Our Director Prof. Dr. Axel Brakhage has been re-elected as Vice President of the German Research Foundation (Deutsche Forschungsgemeinschaft), #DFG! 🗳️ Congratulations! Prof. Brakhage’s pioneering work in microbiology and infection biology, including his research on human pathogenic fungi, has been instrumental in advancing our understanding of microbial communication and developing new antibiotics. As DFG Vice President, he is particularly committed to sustainability in research, the development of research collaborations with China, and to fact-based political decision-making regarding animal testing and genetic engineering. ➡️ For more information, visit our website: https://lnkd.in/eG8H8Kem Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation Friedrich-Schiller-Universität Jena Balance of the Microverse

Hip hip hurray! 🎉 Shuaibing Zhang won the dissertation prize of the Faculty of Biological Sciences at the Friedrich-Schiller-Universität Jena. Congratulations on this great achievement! 🏆 With this prize, the university honors the best doctoral theses of each faculty and celebrates outstanding young scientists from Jena. With his excellent research contributions, Shuaibing Zhang has well earned this special award. Zhang works at the Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut as a postdoc in the Department of Paleobiotechnology, which is headed by Pierre Stallforth. In his doctoral thesis, Zhang identified new bacterial natural products that play an important role in microbial predator-prey relationships between bacteria and amoebae. 🎓🔬✨ https://lnkd.in/ekyhWRHy #Congratulations #AwardWinner #DissertationPrize #BiologicalSciences #YoungScientists #ResearchExcellence #PhD #Postdoc #LeibnizHKI #Paleobiotechnology #FriedrichSchillerUniversity #AcademicSuccess #UniJena #Schillertag #Promotionspreise #PromovierenInJena #BalanceOfTheMicroverse

INCATEurope has been honored with the Lighthouse Award 2024 by the Schweizerischer Nationalfonds SNF (SNSF) in Basel! ✨🏆🤸 The non-profit partnership creates a collaborative network that brings together research, industry, entrepreneurs, and investors to accelerate the development of new #therapies and #diagnostics in the battle against antimicrobial resistance, #AMR. The Lighthouse Award recognizes INCATE’s outstanding contributions to knowledge and technology transfer, particularly in the fight against AMR. Since its beginnings in 2021, INCATE has been a vital force in bridging the gap between groundbreaking research and market-ready solutions, supporting start-ups in developing urgently needed new #antibiotics. 🎉 Congratulations to the entire INCATE team and all partners for this remarkable achievement! Let’s continue to make a difference in global health. 🌍🔬 ➡ https://lnkd.in/eNdhDAsW #INCATE #LighthouseAward #LeibnizHKI #SNSF #NCCRAntiResist #DZIF #UniversityOfBasel Deutsches Zentrum für Infektionsforschung NCCR AntiResist Innovation Office University of Basel Leibniz-Gemeinschaft