CRISPR Medicine News

* 𝗗𝗧𝗠𝗣-𝗣𝗿𝗶𝗺𝗲 𝗠𝗼𝗱𝗲𝗹 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀 𝗣𝗿𝗶𝗺𝗲 𝗘𝗱𝗶𝘁𝗶𝗻𝗴 𝗣𝗿𝗲𝗱𝗶𝗰𝘁𝗶𝗼𝗻𝘀 * Researchers in Iran and Germany have developed a deep-learning model, DTMP-Prime, to improve predictions for Prime Editing (PE) efficiency and pegRNA activity. Researchers can use the tool to select the best pegRNA and nick gRNA (ngRNA) combinations and to accurately predict the efficiency and outcomes of PE experiments. DTMP-Prime combines sophisticated feature selection, deep embedding, and multi-head attention layers to predict the efficiency of PE complexes by evaluating factors affecting pegRNA and target DNA sequence interactions. Read on at the CRISPR Medicine News website to learn more about DMTP-Prime 👇 https://lnkd.in/djsVH6Dg #crisprmedicinenews #crisprmedicine #crispr #geneediting #genomeediting #primeediting Leila Safari Alireza Khanteymoori Roghayyeh Alipanahi

#CRISPRMED25 Update - The 2nd CRISPR Medicine Conference, April 2025 "We are excited to welcome - HuidaGene Therapeutics - as a new Bronze Sponsor of the 2nd CRISPR Medicine Conference, Copenhagen in April 7-11 2025. Co-founder and CEO of Huidagene Tx, Dr. Alvin L., will also speak at CRISPRMED25" Read more about CRISPRMED25: https://lnkd.in/eZxqTfcS 👉 Early bird expires Jan. 3rd 2025 👉 Abstract submission deadline Jan. 17th 2025 #crisprmedicine #crisprmedicinenews #crisprmed24 #crispr #geneediting #genetherapy #celltherapy

𝑯𝒊𝒈𝒉𝒍𝒊𝒈𝒉𝒕 * 𝗜𝗻 𝗨𝘁𝗲𝗿𝗼 𝗡𝗮𝗻𝗼𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗘𝗻𝗮𝗯𝗹𝗲𝘀 𝗕𝗿𝗮𝗶𝗻 𝗚𝗲𝗻𝗲 𝗘𝗱𝗶𝘁𝗶𝗻𝗴 * Delivering mRNA via acid-degradable nanoparticles offers a new frontier in prenatal gene editing, setting the stage for treatments targeting the root causes of neurodevelopmental disorders. A new method uses densely PEGylated lipid nanoparticles to deliver CRISPR-based mRNA editing tools into embryonic brain cells, achieving substantial genetic modifications across the brain with minimal toxicity and long-lasting results. Researchers from University of California, Davis and University of California, Berkeley have used a mouse model to demonstrate a high-efficiency approach to in utero gene editing. The method overcomes traditional barriers by safely transfecting neural stem cells with CRISPR-associated mRNA that can reach large swathes of the brain and introduce precise genetic edits with significant developmental benefits. Continue reading on the CRISPR Medicine News website 👇 https://lnkd.in/dExgcTtE #crisprmedicinenews #crisprmedicine #crispr #geneediting #genomeediting #angelmansyndrome #brain #inutero #prenatal Kewa Gao Hesong Han Niren Murthy Aijun Wang

*CMN Jobs - New Open Position* Title: PostDoc in Functional Genomics Company/Organization: Goethe-Universität Frankfurt a. Main Application deadline: Nov. 9, 2024 Location: Frankfurt am Main, Germany Contactperson: Manuel Kaulich #cmnjobs #crisprmedicinenews #functionalgenomics #crisprmedicine https://lnkd.in/dqPWtUuF

𝐖𝐡𝐚𝐭 𝐡𝐚𝐩𝐩𝐞𝐧𝐞𝐝 𝐢𝐧 𝐂𝐑𝐈𝐒𝐏𝐑 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐭𝐡𝐢𝐬 𝐰𝐞𝐞𝐤? Here are a few teasers.. 🗾 Researchers at Herlev og Gentofte Hospital put Denmark on the global CRISPR Medicine map with approval for the first first gene-editing T cell therapy trial 🏥 Intellia Therapeutics, Inc. shares positive results from the ongoing Phase 2 trial of CRISPR therapeutic candidate NTLA-2002 in hereditary angiodema 🧠 Researchers in China and US report gene editing in the mouse brain - done inside the uterus of a pregnant female mouse- using densely PEGylated lipid nanoparticles. This advance provides hope for the treatment of rare genetic diseases of the brain Check out this week's full CMN Weekly newsletter below 👇🏻 𝑾𝒊𝒕𝒉 𝒊𝒏𝒅𝒖𝒔𝒕𝒓𝒊𝒂𝒍 𝒏𝒆𝒘𝒔 𝒇𝒓𝒐𝒎: Editas Medicine Poseida Therapeutics, Inc. HuidaGene Therapeutics AvenCell Moonwalk Biosciences Arbor Biotechnologies Prime Medicine, Inc. Epicrispr Biotechnologies https://lnkd.in/eJMVUa6G #crisprmedicinenews #crisprmedicine #crispr #geneediting #cmnweekly #crisprtrials

𝐂𝐑𝐈𝐒𝐏𝐑 𝐏𝐥𝐮𝐬 𝐃𝐫𝐮𝐠 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐌𝐚𝐤𝐞𝐬 𝐍𝐞𝐮𝐫𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚 𝐑𝐞𝐬𝐩𝐨𝐧𝐬𝐢𝐯𝐞 𝐭𝐨 𝐈𝐦𝐦𝐮𝐧𝐨𝐭𝐡𝐞𝐫𝐚𝐩𝐲 Researchers in Italy and Australia report a triple combination strategy involving CRISPR that boosts the response of neuroblastoma to immunotherapy. They found that CRISPR-mediated silencing of endoplasmic reticulum aminopeptidase 1 in combination with the histone deacetylase inhibitor and PD-1 blockade significantly improved survival rates without toxicity in a mouse model of neuroblastoma. Read more in our latest brief 👇🏻 https://lnkd.in/ed-f4dHQ #crisprmedicinenews #crisprmedicine #crispr #checkpointinhibitor #immunotherapy #cancertherapy #neuroblastoma

The largest CRISPR medicine event will be in Copenhagen, April 2025... #CRISPRMED25

🚨 𝗔 𝗖𝗥𝗜𝗦𝗣𝗥-𝗺𝗮𝗱𝗲 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗳𝗼𝗿 𝗮𝘂𝘁𝗼𝗶𝗺𝗺𝘂𝗻𝗲 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀! In their latest instalment of their 𝐆𝐞𝐧𝐞 𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐢𝐧 180 𝐒𝐞𝐜𝐨𝐧𝐝𝐬 series, our friends at WeDoCRISPR discuss a recent study in which CRISPR-engineered CAR-T cells could eliminate pro-autoimmune B-cells in 3 patients! The study was carried out at Naval Medical University of Shanghai and the findings were published in Cell. Check out the video by Manel Llado Santaeularia, PhD. and Antonio Carusillo, Ph.D. below 👇🏻 Article link: https://lnkd.in/g5HKS3ud #crisprmedicinenews #crisprmedicine #crispr #wedocrispr #researchbreakthrough #cartcelltherapy

𝐋𝐨𝐧𝐠, 𝐏𝐮𝐫𝐞, 𝐂𝐨𝐦𝐩𝐥𝐞𝐱, 𝐒𝐜𝐚𝐥𝐚𝐛𝐥𝐞 𝐚𝐧𝐝 𝐌𝐮𝐥𝐭𝐢𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐒𝐢𝐧𝐠𝐥𝐞-𝐒𝐭𝐫𝐚𝐧𝐝𝐞𝐝 𝐃𝐍𝐀 – 𝐀 𝐂𝐥𝐨𝐬𝐞-𝐮𝐩 𝐋𝐨𝐨𝐤 𝐚𝐭 𝐌𝐨𝐥𝐢𝐠𝐨 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐢𝐞𝐬 🔎 Moligo Technologies CEO Cosimo Ducani, Ph.D. discusses the start-up’s unique approach to developing single-stranded DNA that is long, pure, complex, scalable and multifunctional, the urgent need for non-viral cell and gene therapies, and much more in our latest interview. Read more at the link below or catch Cosimo at the European Society of Gene and Cell Therapy Congress in Rome this week. https://lnkd.in/eVn8eeym #crisprmedicinenews #crisprmedicine #crispr #geneediting #geneticmedicines #moligotechnologies #nonviraltherapies #DNAsynthesis

#CRISPRMED25 Update - The 2nd CRISPR Medicine Conference "We are excited to welcome, Broken String Biosciences, as one of the industrial speakers at the 2nd CRISPR Medicine Conference, #Copenhagen in April 8-11 2025" The global CRISPR medicine community will meet again in Copenhagen and share the latest discoveries and discuss the future challenges within this exciting field. 👉 Early bird expires Jan. 3rd 2025 👉 Abstract submission deadline Jan. 17th 2025 Read more about CRISPRMED25 - The confirmed speakers, available workshops, the sponsors/supporters, relevant deadlines... https://lnkd.in/eZxqTfcS #crisprmedicine #crisprmedicinenews #crisprmed24 #crispr #geneediting #genetherapy #celltherapy