Immudex

☀️ Join us at the La Jolla Immunology Conference! Elizabeth Epps, PhD will be presenting an insightful poster, “The Potency Evaluation, Activation and Expansion of Antigen-Specific T cells in Blood" When & Where: 📍 Session Title: POSTER SESSION 2 - (II-1) ⏲️ Poster session: Wednesday, October 16th | 1:10pm - 3:10pm Want to explore more? Visit our poster or stop by our booth to chat with our immune monitoring specialists. We look forward to connecting with you! #Immunology #ImmuneMonitoring #Immunotherapy

Boost your detection of antigen-specific B cells with dual staining! 🌟 In the rapidly evolving field of antibody-based immunotherapies, accurate detection of antigen-specific B cells is key. Klickmer® is now available with BV421 in addition to FITC, PE, and APC, providing more options for dual staining of antigen-specific B cells. This enables reliable B cell analysis using flow cytometry with minimal background interference. Klickmer® technology can easily be conjugated with mono-biotinylated molecules of your choice for tailored B cell detection. In a recent study, we assembled Klickmer® BV421 and PE reagents with SARS-CoV-2 spike proteins for longitudinal detection and phenotyping of antigen-specific B cells after vaccination. Read more about the study by following the link in the comments! 👇👇 #Bcells #flowcytometry #antigenspecificity #immunophenotyping #Fluorophores

📣The first five-layer multi-omics dataset using #dCODE #Dextramer® and the BD Rhapsody #single-cell platform for the characterization of human antigen-specific T cells, capturing: ▪️ Whole transcriptome ▪️ TCR sequences ▪️ T cell antigen specificity ▪️ Surface marker proteins ▪️ Sample multiplexing combining two distinct hashing approaches One key question was whether Dextramer® could detect antigen-specific T cells at low frequencies. The results of spike-in experiments confirmed that Dextramer® were indeed capable of this, even when spike-in frequencies were below 1%. For instance, one clone had a frequency as low as 0.4%, yet Dextramer-positive cells from this clone were still detectable. Find the link to the full article in the comments! 🙌 #Tcells #Immunology #ImmunologyResearch #antigensspecificity

Check out this job at Immudex USA: Customer Service Representative

Join our live webinar on “Evaluation of TCR-pMHC Affinity and its Implications for T Cell Therapies” with Immudex and QUALITY ASSISTANCE S.A.   Register now for the webinar on October 30th covering:  🔹 Challenges associated with production of high quality TCR monomers suitable for TCR affinity measurement   🔹 The importance of TCR affinity measurement in the context of development of T cell therapies  🔹 Introduction to two techniques used for affinity measurement: Surface Plasmon Resonance and Biolayer Interferometry, and the advantages/disadvantages of each technique  🔹 Results of a case study investigating the interaction between a modified affinity-enhanced TCR targeting the NY-ESO I antigen and its cognate pMHC (HLA-A*0201 / SLLMWITQC) in terms of affinity and kinetics  🔹 Recommendations on best practices for TCR-pMHC affinity measurement     Secure your seat and mark your calendar!🙌    You can choose from two live sessions:  🔘 1 pm CET / 8 am EDT / 5 am PDT or 🔘 6 pm CET / 1 pm EDT / 10 am PDT

Team #Immudex is at #CATC in Copenhagen to soak up the latest #CART #TCR knowledge and discuss advances in the field. We caught up with Christopher A. Klebanoff, M.D. who presented data from his lab and collaborations on “Immunogenicity and therapeutic targeting of recurrent RAS public neoantigens” including use of our MHC #Dextramer® and #dCODE® technology. 👏 Don’t miss our latest poster on “Developing a Platform for High-Throughput Screening of TCR Mimic Specificity using #TCRm Dextramer®”, presented by our R&D Research Scientist, Dr. Amalie Skak Schøller. You can also download a copy of the poster in the link in the comments! 👇 Find us at the booth in between talks for discussions on precision immune monitoring! #CARTCR #flowcytometry #celltherapy #TcellTherapy

And that concludes our symposium here in Oxford today! 🙌🏼 Thank you to this afternoon's speakers Prof. Andrew Sewell, Yanchun Peng (on behalf of Prof. Tao Dong), Dr. rer. nat. Sebastian Klein and Dr. Mohammad Salem for their great talks.   We hope that the symposium was a valuable opportunity for everyone attending.   Would you like to attend a similar symposium? 📢 Stay tuned for the next Immudex Symposium which will be announced soon! #immunology #immunologyresearch #immunemonitoring #flowcytometry

It's great to welcome everyone to the Oxford Symposium today! "T-cells and Antigen-Specificity – Applications in Infectious Disease and Immuno-Oncology" Thank you to this morning's speakers Prof. Nicola Ternette, Prof. Simon Davis, and Dr. Thomas Holberg Blicher for their insightful talks! We are looking forward to the sessions this afternoon! Stay tuned for updates 🙌🏻 #immunology #immunemonitoring #antigensspecificity #Tcells #Immunotherapy #CellTherapy

📣 This Cell paper shows that CD8+ T cells deficient in both PD-1 and LAG-3 mediate enhanced tumor clearance and long-term survival in mouse models of melanoma! Immune-mediated resistance to PD-1 blockade is a challenge to overcome. This study sheds light on how PD-1 and LAG-3 synergize to hinder anti-tumor immunity. The study reveals that the absence of both PD-1 and LAG-3 results in reshaped exhaustion patterns and heightened anti-tumor immune responses, potentially mediated by an autocrine IFN-γ-dependent mechanism. Melanoma-specific cells in PBMCs from melanoma patients were assessed based on positive #Dextramer staining for four immunodominant HLA-A2-restricted epitopes in MART1, NY-ESO-1, gp100, and tyrosinase (Mel Dex+). These findings could pave the way for novel therapeutic strategies in the fight against cancer. 👏 Find the link to the full article in the comments! #flowcytometry #immunology #immunotherapy #Tcells #checkpointinhibitors

The addition of BV421 to our portfolio allows for easy integration of MHC #Dextramer® reagents in immune profiling panels. To illustrate this, we have used MHC Dextramer® BV421 reagents as additional components in a commercial immune profiling panel to extend the analysis of surface markers with information about antigen-specificity. The panel we used was the BD Horizon™ Human T Cell Backbone Panel from BD Biosciences. We obtained detailed characterization of CMV-specific memory T cells in the blood of an individual with latent CMV infection. Read more about this study in our latest blog! Find the link in the comments. 🙌 #MulticolorFlow #flowcytometry #antigenspecificity #immunophenotyping #PanelDesign #Fluorophores BV421 is equivalent to Brilliant Violet™ 421, which is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, and is used under license. Powered by BD Innovation.