HansaBioMed Life Sciences Ltd

The exploitation of EVs in diagnostic or therapeutic settings requires their detection in a targeted fashion. This is generally achieved by targeting transmembrane proteins (TMPs), mostly tetraspanins, that are known as universal EV markers. Jesus M. Lopez Balthazar, Wenchao Gu, and Qiuming Yu from Cornell University stated that individually targeting CD9, CD63, or CD81 for detection and quantification of EVs neglects the lateral associations formed between tetraspanins and other TMPs, also known as tetraspanin-enriched microdomains (TEMs). In order to account for that, the researchers utilized EVs derived from RAW 264.7 cells on SPR biosensors functionalized for co-targeting CD9, CD63, and CD81 markers. Their results demonstrated a statistically significant increase in EV capture for CD81/CD63 and CD81/CD9 dual-antibody surfaces, suggesting the promotion of capture efficiency by co-targeting. While this approach sets an example approach for an improved and more sensitive detection of EVs, such an improvement has also implications for clinical profiling by targeting non-tetraspanin TMPs through their associated tetraspanin partners for TEM formation. If you are interested in further reading: https://lnkd.in/dn8Pf3Yp #extracellularvesicles #exosomes #SPR #biosensing #EVdetection

Another amazing achievement! I am very happy to share that HansaBioMed Life Sciences Ltd has been ranked #2 among the #Top5 Most Profitable Companies in Retail Sales in #Estonia! 🏆 This recognition reflects our commitment to delivering high-quality products and services, our dedication to the innovation, and the great work of our talented team. Thank you to our customers, partners, and everyone who has supported us on this journey. #exosomes #evs #lifesciences #nanoparticles

Extracellular vesicles, including exosomes, attract high level of interest for cosmetic applications in the recent years. This is the result of their proven anti-inflammatory, antioxidant, anti-aging, and skin rejuvenation effects. However, the understanding of commercial development of EV-based cosmetics differs from that for therapeutic applications. This stems basicly from the discrepancies between dosages, application methods, formulations (i.e., including excipients), as well as other ingredients included in the final product that requires certain storage conditions to maintain EV integrity and functionality. In a recent review, a group of researchers (Clara Rodriguez, Alexandre Porcello, PhD, Michele Chemali, Wassim Raffoul, Cintia Marques, Corinne Scaletta, Kelly Lourenço, Philippe Abdel-Sayed, Lee Ann Laurent-Applegate, Fanny Pelissier Vatter, and Alexis Laurent) provided a general and broad outlook on the current state of the EV-based research for cosmeceuticals and the aspect of commercialization. This review not only highlights the potential of plant, human, or animal-derived EVs, but also develops a useful understanding in the barriers and limitations in their commercialization from a technical as well regulatory point of view. If you are interested in further reading: https://lnkd.in/dCMuW4hG #extracellularvesicles #plantEVs #cosmetics #antiaging #rejuvenation

By now it is well-known that EVs regulate intercellular communication via biological molecule transfer. But, is it only the biological material that they encapsulate and carry towards their target cells? This is the question that Kamil Adamiak, Marta Sidoryk-Węgrzynowicz, Beata Dąbrowska-Bouta, Grzegorz Sulkowski, and Lidia Struzynska from Mossakowski Medical Research Institute - Polish Academy of Sciences raised, considering the extensive plastic production and the discoveries on the health threats posed by plastic nanoparticles. In order to probe into the intercellular fate of plastic nanoparticles, the researchers used primary astrocyte cultures to be exposed to polystrene nanoparticles (PS-NPs), a non-biodegradable material used commonly for food storage and transportation. Their study not only revealed that astrocyte-internalized PS-NPs are packed into EVs derived from these astrocytes, but the protein cargo of these EVs is also affected by the exposure to PS-NPs. Despite the requirement of further studies to evaluate the implications of such cargo alteration, it is a clear demonstration of the role of EVs in intercellular transport of PS-NPs neurotoxicity. If you are interested in further reading: https://lnkd.in/dFRH_Res #extracellularvesicles #exosomes #EVs #plasticnanoparticles

Next stop: Baltimore! Together with our local partner Galen Molecular, we are counting down to meet EV researchers and technology providers in ISEVxTech 2024 in Baltimore, Maryland, USA. Meet us to learn more about our innovative EV solutions! #extracellularvesicles #exosomes #ISEVxTech2024 #ISEV

Are you trying to isolate your EVs from challenging matrices such as plasma or serum, but concerned about their purity? Then, here we present to you Exo-TFF (in collaboration with our partner Microgentas), an ideal solution for maximized EV purity. Check our innovative solution below and contact us for any further details or requests! #extracellularvesicles #exosome #EVisolation #tangentialflowfiltration #ionexchangechromatography

Our wide range of EV products help EV researchers reach new heights, and here is a short-list to prove that. In October, we have welcomed 6 publications with our innovative solutions thus far. Here is a list of all these valuable research output: - Qingyu Lei, Thanh H. Phan, Shiva Kamini Divakarla, Bill Kalionis, and Wojciech Chrzanowski delved into the EV-mediated mechanism of intercellular metal exchange by using papaya fermented fluid EVs and decidual MSC EVs: https://lnkd.in/dwX5aUxc, - Naglaa H .Shalan, Norhan Mosaad Morgan, Rasha M.Abdrabh, Abd ElLatif M. Elbalshy, and Rana M. Abdallah demonstrated the prognostic and diagnostic role of TM9SF4 in colorectal carcinoma in a comparison with nuclear morphometry: https://lnkd.in/d_Sy9tAm - Tatyana A. Druzhkova, Marina Yu. Zhanina, Elena E. Vladimirova, Alla Guekht, and Natalia V. Gulyaeva revealed the association between serum EV proteomic spectrum and cognitive impairment in the post-stroke period: https://lnkd.in/dFMScTnA - Dávid Szöllősi, Polett Hajdrik, Hedvig Tordai, Ralf Bergmann, Ildiko Horvath, Judith Mihaly, Anikó Gaál, Jezsó Bálint, Kanni Das S, Tamás Felföldi Parasuraman Padmanabhan, Balázs Zoltán Gulyás, Domokos Máthé, Zoltan Varga, and Krisztián Szigeti illustrated a novel approach for efficiently imaging OMVs during in vivo studies: https://lnkd.in/dHgn9x-z - July Constanza Buitrago-Gutiérrez, Sarah Morris, Astrid Backhaus, Gesa Kaltenecker, Dr. Jagan Mohan Kaipa, Cyrille Girard, Ph.D., Stefan Schneider, and Jens Gruber unraveled the promise of iMSC-EVs as an alternative to MSC-EVs in therapeutic settings: https://lnkd.in/dxURj6xw - Ralf Hass, Juliane van der Ohe, and Tianjiao Luo suggested a new method to improve the anti-cancer properties of MSCs through an elevated tropism of MSC-EVs: https://lnkd.in/dzHFG9bx Together with the research community, we will continue to pioneer EV field, as we have been doing for more than 15 years! #extracellularvesicles #exosomes #EVs

What do you think of testing your knowledge on extracellular vesicles before you head off to a relaxing weekend? If you say yes, here is our first-ever EV lab quiz question! Do you have the answer? #extracellularvesicles #exosomes #EVs #EVlabquiz

As HansaBioMed Life Sciences, one of our focus areas is plant EV-like nanoparticles in the recent years, and here is a neat review article to show why. In this review, Siyu Hao et. al. provided a broad outlook of the biogenesis and biological content of plant EVs together with the status-quo in plant EV research. By the help of literature-based proof of a variety of plant EV sources for their anti-inflammatory, anticancer, and antioxidant effects in both in vivo and in vitro studies, the researchers highlight the role of plant EVs in several different applications. The review also points out to the fact that major concerns like safety, biocompatibility, and resource availability for large production put plant EVs one step ahead in comparison with animal-derived EVs. In the end, all these advantages make plant EVs an ideal candidate for the future of therapeutic and cosmetic applications. Grasping this vision, we not only offer plant EV standards from different sources, but also our expertise as plant EV production service in bulks for those interested in exploiting the miracles of plant EVs in their novel products. If you are interested in the merits of plant EVs but need some assistance, just contact us! For those interested in further reading: https://lnkd.in/du9ua6tj #extracellularvesicles #plantEVs #therapeutics #cosmetics

Are you interested in studying platelet-derived EVs to exploit their roles in immune response, inflammation, and wound healing for novel diagnostics and therapeutics? Then, our brand-new product platelet EVs developed in collaboration with Laitinen Saara and Finnish Red Cross - Suomen Punainen Risti is just for you! Our optimized isolation protocol ensures their scalable manufacturing, reproducibility, as well as a consistent lipoprotein content reduction in comparison with standard methods. Depending on your use case, platelet EVs are available in lyophilized or frozen form. If you are interested in knowing more about the product: https://lnkd.in/dwXiK-kA #extracellularvesicles #exosomes #plateletEVs