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With beauty from within still being a hot market, finding new skin health ingredients is critical. About seven months ago I learned about Bioiberica's HA Matrix (Dermial®). While most collagen-type ingredients require multiple grams to work, Dermial is different. Here is why: Dermial® is a patented natural ingredient containing three key naturally occurring compounds that benefit skin health: Hyaluronic Acid (HA), Collagen, and Polysaccharides. Hyaluronic Acid Hyaluronic acid is primarily found in the eyes, joints, and skin fluids. Its main function is to help the body retain water in tissue, i.e., Lubrication and Moisture. Its impact on the skin is to improve wound healing, decrease fine lines and wrinkles, decrease dry skin, reduce roughness of skin, improve Hydration, and improve elasticity. Collagen We mentioned the importance of collagen previously. Sulfated polysaccharides (Dermatan and Chondroitin Sulfate) The role of dermatan sulfate (DS) has been demonstrated in tissue development under the epidermis, blood vessels, and bone via an interaction with collagen. DS is essential for tissue development and the assembly of collagen fibrils in the skin.[iii] Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments, and tendons. CS induces the expression of type I collagen and has the potential to facilitate skin regeneration, implying that CS could be clinically applied to improve skin aging.[iv] Scientific data shows that Dermial®: · Improves the hydration and elasticity of the skin. · Acts as a potent regenerative agent · Boosts the quality of the dermis and epidermis layers to help maintain skin health. · Significantly increases the production of elastin. · Increases the production of Type I collagen (Responsible for skin elasticity, firmness, and structure.). · Promotes the production of Type III collagen (Supports the tensile strength of the skin). · Increases the production of HA (in dermal fibroblasts). [i] Torrent, A et al. The FASEB Journal, 2013;1S:633.2. [ii] Gálvez et al. Experimental Biology 2022 Meeting Abstracts [iii] Mizumoto S, Yamada S. The Specific Role of Dermatan Sulfate as an Instructive Glycosaminoglycan in Tissue Development. Int J Mol Sci. 2022 Jul 5;23(13):7485. doi: 10.3390/ijms23137485. PMID: 35806490; PMCID: PMC9267682. [iv] Min D, Park S, Kim H, Lee SH, Ahn Y, Jung W, Kim HJ, Cho YW. Potential anti-aging effect of chondroitin sulfate through skin regeneration. Int J Cosmet Sci. 2020 Oct;42(5):520-527. Doi: 10.1111/ics.12645. Epub 2020 Aug 20. PMID: 32583476.