NADMED Ltd.

Article of the Week: Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis (2023) The authors of this study report that exercise increases NAMPT enzyme level, which is part of the NAD+ synthesis pathway. While they did not study NAD+ metabolites, they concluded that exercise, even in aged subjects, might improve NAD+ homeostasis. 🔸 Read the full article: https://lnkd.in/dhtbxcNt #NADs #NADplus #NADscience #exercisetraining

Honoured to have Dr. Wolfgang Grisold, President of the World Federation of Neurology, visit the NADMED booth at ICNMD 2024! Thank you for the insightful discussions! #ICNMD2024 #Neurology #NADMED

Article of the Week: Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death (2023) This article describes intensive-care COVID-19 patients in two Dutch hospitals, and finds that NAD+ and NADH were the most decreased metabolites in metabolomic analysis of their platelets. However, almost all the patients were treated with dexamethasone, a major metabolic modifier, and the control individuals were healthy caretakers, thus the link with COVID-19 remains unclear. 🔸 Read the full article: https://lnkd.in/d29BhGXC #NAD #NADplus #NADscience #COVID19 #mitochondrialdysfunction #NADMED 

Article of the Week: Healthy aging and muscle function are positively associated with NAD+ abundance in humans. This study by Janssens et al. (2022) reports that muscle NAD+ decreases by aging and correlates with the amount of steps taken by day. The authors show that regular exercise of aged individuals increased NAD+ metabolism close to that of younger subjects. Therefore, exercise is an excellent NAD+ booster. 🔸 Read the whole article: https://lnkd.in/gzXf3aM9 #NADscience #NAD #NADplus #aging #NADMED

October 25-29 NADMED will be at the ICNMD 2024 in Perth, Australia! Come visit our team members, Riikka and Joonas at booth 305 to discuss the importance of measuring REDOX metabolites in the management of neuromuscular diseases. 🧪 #ICNMD2024 #NeuromuscularDiseases #REDOXMetabolites #NADMED #MetabolicHealth #Biotechnology

Article of the week: Recessive NADSYN1 gene variants affect the NAD+ metabolome and NAD+ levels, and cause congenital malformations. In the study by Szot et al. (2024), the authors generated mice with inactivating genetic modifications of NAMPT, either in one or two copies of the gene. They found that malformations in the pups were prevented by NAD+ precursor treatment of the pregnant female mice. If the mother carried one copy of the NAMPT-mutant gene and one healthy one, supplementation with any vitamin B3 type resulted in healthy pups. However, if both copies were inactive ones, the B3-form needed to be amidated (nicotinamide, nicotinamide mononucleotide) to prevent malformations. The study indicates that different B3 forms have different functions depending on the disease context. 🔸 Read the full article: https://lnkd.in/dQAWgYDZ #NAD #NADplus #nadscience #NADMED

Meet these gentlemen at CPHI Milan! Stop by booth 6SU69 to hear the latest insights on NAD.

Article of the Week: Targeting NAD+ metabolism: dual roles in cancer treatment (2024). The article by Yong et al. summarizes different studies focusing on NAD+ metabolism in cancers. To conclude, in some cancers, the NAD-synthesis enzyme NAMPT is high, and its inhibition can make the cancers sensitive to antitumor therapy. However, in other cancers, no changes in this enzyme occur. High extracellular (serum/plasma) NAMPT predicts poor prognosis. The conclusion is that different cancers vary in their NAD+ metabolism, and no general guidelines of NAD-metabolic targeting in cancers can be given. 🔸 Read the full article: https://lnkd.in/d-SA7tes #NAD #NADplus #cancertreatment #NADMED

On World Heart Day 2024, we’re showcasing NAD+'s role in cardiovascular health! A review article by Zhang et al. (2022) brings together numerous studies that have found a link between NAD+ levels and cardiovascular diseases. Here are a few takeaways: 🔸 NAD+ is essential for energy production in heart cells. Studies discussed in the review article show that maintaining healthy NAD+ levels can support heart function by influencing energy pathways. 🔸 NAD+ is crucial for maintaining redox balance, which regulates oxidative stress – a major contributor to heart disease. Restoring NAD+ levels can help manage oxidative stress and improve heart function, especially in conditions like myocardial infarction and heart failure. 🔸 NAD+ also plays a role in managing inflammation, a key factor in cardiovascular diseases. It may regulate immune responses and reduce inflammatory markers linked to cardiovascular diseases. Read the full article here: https://lnkd.in/dw_2FC4H #NADs #NADplus #cardiovasculardiseases #worldheartday #NADMED

Article of the Week: How do traffic emissions affect human olfactory cell function? A study, led by the University of Eastern Finland, explored molecular-level changes occurring in human olfactory mucosa cells when exposed to traffic-related ultrafine particles (UFPs). Using the NADMED method, researchers discovered that UFPs disturb NAD and glutathione metabolism, leading to increased ROS and oxidative stress. Notably, Alzheimer’s disease cells showed greater disturbances in NAD metabolism compared to cognitively healthy cells when exposed to these emissions. 🔸 Read the full article: https://lnkd.in/dj3wUy_J 🔸 Learn more about NADMED's laboratory services: https://lnkd.in/denZdbYd #NADs #NADplus #ultrafineparticles #alzheimersdisease