DNA Script

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Viral infection in fruit flies can alter intestinal homeostasis and lead to physiological changes. Researchers from Institut Pasteur and Institut Curie in Paris employed fluorescently labeled #DNA #oligonucleotides printed by enzymatic DNA synthesis (#EDS) to track viral infection of the fruit fly gut using a technique called RNA FISH. The group found that infection of flies with the Drosophila A virus (DAV) led to changes in intestinal homeostasis, including an over-proliferation of intestinal stem cells (ISCs). The group found that DAV infection caused cytokine release through a JNK signaling pathway, leading to ISC proliferation through growth factor signaling pathways. Sting-Relish NF-κB signaling was found to be required for the ISC proliferation, and the over-proliferation of ISC cells within the fruit fly #gut led to a shortened #lifespan. A marker for age-associated intestinal dysplasia was upregulated in infected flies. This research highlights how viral infection affects intestinal physiology and revealed important interactions between immune pathways, gut physiology, and aging. #DNAprobes #aging #fruitfly Viral infection disrupts intestinal homeostasis via Sting-dependent NF-κB signaling in Drosophila: Current Biology (cell.com)

#Apoptosis, or programmed cell death, is a mechanism by which the body may eliminate unnecessary, dysfunctional or highly damaged cells. One mechanism of triggering apoptosis involves the clustering of death receptors on the cell surface.   A team at the Karolinska Institutet in Stockholm, Sweden recently published a study in which #DNA origami was used as a switchable control to induce apoptosis in #cancer.   Reporting in the journal Nature Nanotechnology, the researchers created a DNA origami which contains ligands that, when exposed, bind and cluster death receptors together, triggering cell death. Under the slightly basic pH conditions of normal cells, the ligands are hidden. However in the lower pH conditions of a solid tumor, the ligands are exposed, causing tumor cells to die.   The approach was used in mice containing human breast cancer #xenografts and showed up to a 70% reduction in tumor growth. This approach holds promise as a DNA-based method for treating solid tumors in humans. #syntheticbiology #therapeutics #oligonucleotides   https://lnkd.in/dWVr-wDj

  Science and Technology were featured during the VivaTech 2024 week, Europe's biggest annual start-up event.   Biotech companies were represented alongside DNA Script, and we were happy to celebrate other companies joining the French Tech ranking for 2024, including TreeFrog Therapeutics ImCheck Therapeutics Ÿnsect Innovafeed   DNA Script is excited that VivaTech captured the next innovations and trends, by putting light on new and exciting R&D developments in Europe and around the world such as AI & biosecurity, bioprinted skin, gene synthesis, and cell-based therapies.   #DNAsynthesis #DNAondemand Viva Technology La French Tech Marina Ferrari Clara Chappaz

We are proud to announce that DNA Script is now part of the French Tech Next40 from LaFrenchTech! 🎉🏆   This recognition is a validation of our ongoing commitment to innovation and growth, placing us among France's 40 most successful start-ups. Being a French Tech Next40 winner is an honor that underscores our ability to become a world-class technology leader.   We warmly thank the French Tech Mission for this distinction and their support. We look forward to collaborating with the other laureates to continue to make the ecosystem of start-ups in France shine on the world stage!   Clara Chappaz Marina Ferrari Bruno Le Maire Gabriel Attal Emmanuel Macron Vivatech DNA Script Thomas Ybert Sylvain Gariel Xavier Godron

We’re excited to be at PEGS in Boston! Come stop by booth #35 to chat with us about enzymatic DNA synthesis. We look forward to seeing you! Rob Wilson Raymond DiDonato Gweltas Odye, PhD Melissa Gentz Jooyoung Park, PhD #DNAsynthesis #DNAonDemand

Come stop by our booth at the Future of Biotechnology in Individualized Medicine conference in San Diego! We hope to see you there! Michael Delaney Sullivan #DNAScript #DNAonDemand #DNAsynthesis

We are excited to be attending SynBioBeta this week! Come meet us at booth #419 to chat with Michael Delaney Sullivan about how enzymatic DNA synthesis is powering drug discovery and development. #synbiobeta #EDS #DNAsynthesis #proteinengineering

Join us today at SynBioBeta! Our CEO, Thomas Ybert will be speaking at "From Complexity to Commercialization: The DNA Synthesis Saga Continues" at 9:05 AM. We look forward to seeing you there! 📅 RSVP here: https://lnkd.in/eQ4nw2yK #synbiobeta #DNAsynthesis #EDS #DNAondemand

Metastatic castration-resistant #prostatecancer (mCRPC) is often lethal and outcomes range from slow growth to aggressive onset leading to death. Prognostic tools are limited in their ability to predict outcomes.   An international group of researchers recently published a study in the journal Nature examining circulating tumor DNA (#ctDNA) for its prognostic value in mCRPC.   The study found that ctDNA fraction correlates with other measures of disease and predicts overall survival, progression-free survival and treatment response.   The group also developed a machine-learning tool to determine whether a patient has enough ctDNA fraction to be useful for prognostics and risk stratification. #cancer #liquidbiopsy #patientstratification https://lnkd.in/emXRMDAH