EphyX Neuroscience

🧠 Epilepsy Insights with Brain Slice Electrophysiology 🧠 At EphyX Neuroscience, we leverage brain slice electrophysiology to create a physiologically relevant environment for studying various pathological conditions and evaluating the impact of your lead compounds on neuron-specific activities. This approach yields highly valuable functional insights. For example, we routinely employ a range of in vitro models to assess the potential of test compounds and their mechanisms of action in the context of epileptic seizures. One notable model utilizes Oxotremorine, a muscarinic acetylcholine receptor agonist that mimics the hyperactivity observed during epileptic seizures. By selectively activating cholinergic pathways, Oxotremorine enhances neuronal intrinsic excitability. This effect is clearly demonstrated through whole-cell patch-clamp recordings of a CA1 pyramidal cell before and after Oxotremorine application: increased firing frequency for a given current injection step, and the generation of spontaneous bursts of action potentials. Interested in discussing your seizure-related research projects or exploring more thorough sample data on the subject? Don't hesitate to reach out to us at contact@ephyx-neuroscience.com. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #Epilepsy #EpilepsyResearch #inVitroModel

A massive congratulations to the authors on their groundbreaking research results! This work holds great potential for advancing global understanding of Fragile X Syndrome. EphyX Neuroscience is truly honored to have had the opportunity to support this significant endeavor. The article is available here: https://lnkd.in/eABtQxkj #FragileXSyndrome #ResearchBreakthrough #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience

🚀 Boost your preclinical and R&D projects with EphyX Neuroscience! Our expertise in electrophysiology delivers highly valuable and predictive functional data under physiological conditions. Proudly delivering top-quality, swift, and flexible services, we've achieved a 100% reconduction rate for contracts in 2022 & 2023 🚀 But don't just take our word for it – hear what some of our valued customers have to say about our services and approach. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

At EphyX Neuroscience, we're committed to what truly matters to our clients: exceptional data quality, adaptive protocols, and swift delivery. Partner with us for your electrophysiology data needs and expect: ✅ Unmatched Protocol Flexibility: - On-the-go adjustments, even on short notice. - Pause or stop ongoing contracts if data doesn't support further collection. ✅ Diverse Technical Approaches: Including patch clamp, optogenetics, calcium imaging, organotypic slice cultures and iPSC-derived human neuronal cultures. ✅ Expert Team: Dedicated PhD experimenters with extensive experience in their fields. ✅ High-Quality, Actionable Data: Empowering you to make informed, optimized decisions. 🌐 Discover more about our services: www.ephyx-neuroscience.com ✉️ Have questions? Let's connect: contact@ephyx-neuroscience.com We're eager to support your electrophysiology data needs and help drive your success! #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

in vitro Calcium Imaging can help you understand your compounds' mechanisms of action at the neuronal network level. ➡ Streamlined Lead Selection: Optimize your lead compounds with a functional assay that rapidly demonstrates their impact on neuronal networks. ➡ Long-Term Monitoring: Measure neuronal activity over extended periods using e.g. organotypic slice cultures. ➡ Cell-Type Specific Insights: Utilize genetically encoded dyes for precise, cell-type specific monitoring. ➡ Versatile Integration: Combine with other techniques like patch-clamp for single-cell calcium transient analysis or viral shRNA expression for targeted gene silencing in organotypic brain slices. Ready to advance your research? We're here to support you! 📧 contact@ephyx-neuroscience.com to explore how our expertise can enhance your research journey. 🚀 We look forward to connecting and discussing your project! #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

At EphyX Neuroscience, we take immense pride in our steadfast commitment to scientific excellence, the generation of top-tier data, and fostering strong collaborative partnerships with our valued clients. This is made possible by the exceptional expertise of our team, consisting of PhD-level experimenters with specializations across various subfields of electrophysiology, and the use of advanced equipment. We are excited to announce our recent move to a new, state-of-the-art facility thanks to our partners from the INCIA at the University of Bordeaux, that will enable us to continue enhancing and expanding our diverse portfolio of service offerings. #Scientificexcellence #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

Electrophysiology can provide valuable functional insights for pain research. At EphyX Neuroscience, we routinely employ a range of in vivo and in vitro models to assess the potential of test compounds as well as their mechanisms of action in pain research. As an example, synaptic potentiation (long-term potentiation, LTP) is considered a potential key contributor to pain sensitization and compounds that limit this potentiation may present interesting properties to prevent pain-related pathologies. Below is a short description of what can be expected from single cell recording of a superficial lamina I neuron with electrical stimulation (here Theta burst stimulation, TBS) of the dorsal root as a mean to assess a test compound’s potential in preventing LTP. The top panel (A) depict the recording setup. The bottom panel (B) shows sample traces of the recordings during baseline and after-TBS conditions. Panel (C) shows the time course of normalized excitatory post-synaptic currents (EPSCs) before and after TBS with and without test compound pre-incubation. Panel (D) shows the quantification and comparison of LTP with and without test compound by comparing a 6-min average EPSCs amplitude 50min after TBS to that of baseline. Don't hesitate to contact us at contact@ephyx-neuroscience.com to discuss your pain-related research projects or if you would like to see more thorough sample data on the subject. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #PainResearch

At EphyX Neuroscience we focus on in vitro electrophysiology for preclinical research and drug discovery in the Central Nervous System (CNS) area. Our mission is to empower our clients with the knowledge they need to make informed decisions about their compound selection by providing comprehensive insights into the mechanisms of action and neuronal physiology, using both rodent and human preparations. We understand that every research project is unique, which is why we offer customized solutions tailored to consider your specific needs and constraints. Whether you're looking to optimize your lead compound selection, understand the mechanism of action of a new drug, or investigate the physiological properties of neuronal networks, we have the expertise and technology to help you achieve your goals. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

Electrophysiology serves as a fundamental tool in the investigation of epilepsy, providing valuable insights into the underlying mechanisms of this complex neurological disorder. At EphyX Neuroscience, we routinely employ a range of epilepsy in vitro models including transgenic rodents and/or pharmacologically-induced epileptiform activity to test the effects of drug candidates. Below is a short example of what can be expected qualitatively from single cell recording of a CA1 pyramidal cell and pharmacological induction of epileptiform activity in P30 C57/Bl6 mouse acute brain slice using a combination of low magnesium and gabazine. The top panel (A) shows the spontaneous bursts of action potentials (APs) elicited in this condition compared to baseline standard ACSF. The bottom panel (B) shows the hyperexcitability of the cell when eliciting action potentials. Typical analysis would focus on the APs frequency, threshold, height and half-width but we adapt to your needs to extract and analyse the most relevant parameters for your project. Don't hesitate to contact us at contact@ephyx-neuroscience.com to discuss your epilepsy research projects or if you would like to see more thorough sample data on the subject. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #Epilepsy

Human neurons derived from induced-pluripotent stem cells (iPSCs) is a highly physiological and robust preparation that can be seamlessly integrated with electrophysiology to decipher mechanisms of action (MOA) and produce functional, predictive data. The benefits are substantial: 🔸 Empower your decision-making process with functional data obtained from human neurons. 🔸 Several disease models exist, with cells derived from patients and carrying specific mutations. 🔸 Various cell types are available and are suitable for use as both mono or co-cultures (ex. 75% Glutamatergic, 20% GABAergic and 5% Glial cells). For any queries or further information, don't hesitate to reach out to us at contact@ephyx-neuroscience.com. We look forward to hearing from you and exploring how we can contribute to your research. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #MOA