GENOSKIN

🌟 Exciting News from Genoskin! 🌟 We are thrilled to announce that our Chief Scientific Officer, Dr. Nicolas Gaudenzio, will be giving a presentation for the renowned Global ImmunoTalks #webinar series organized by the Mount Sinai Hospital in NYC! 🧠🧬 📅 Save the Date: Wednesday, September 18th, 2024 📢 Presentation: "Harnessing mast cell heterogeneity in mice and humans: from fetal imprinting to childhood eczema" Nicolas will dive into the fascinating world of #neuroimmunology and #eczema, shedding light on the role of #mastcell heterogeneity in both mice and humans. Join his session next week to gain fresh insights from cutting-edge #research on #immunesystem intricacies! 👩🔬👨🔬 👇 Register now 👇 https://lnkd.in/ePGq3KDf

🌟 The Hidden Role of Mast Cells in Injection Site Reactions (ISRs): What You Need to Know 🌟 Mast cells are a key player in the body’s reaction to injections. When activated by specific triggers like neuropeptides or some therapeutic agents, they release inflammatory substances—such as histamine and tryptase—causing common ISR symptoms like swelling, redness, and pain. With ImmunoSafe: ISR Platform®, we leverage innovative human skin models to mimic how your injectable therapeutics will interact with the human immune system. This allows us to anticipate ISRs, offering a proactive approach to ensure your product’s safety. 🔬 Why Choose ImmunoSafe: ISR Platform®? Real Human Skin Models: We use human skin tissue, not animal models or reconstructed tissues, ensuring a more realistic and clinically relevant response. In-Depth Immune Response Analysis: Our platform analyzes the release of cytokines and tracks immune reactions across multiple donors to provide reliable, data-driven insights. Cutting-Edge Bioinformatics: Powered by AUDACY, our platform uncovers the biological pathways behind ISRs, helping you make informed decisions earlier in development. Protect your therapeutic success and minimize risks before going to clinic! 👉 Explore how ImmunoSafe can enhance the development of your injectable therapeutics https://bit.ly/3MEa93l

In the race to develop effective vaccines, understanding the immune response is key. This is where #transcriptomics comes into play, offering a powerful lens to decode the complex biological processes that occur when our bodies respond to a vaccine. 🤔 So, what makes transcriptomics a game-changer? Transcriptomics provides a comprehensive snapshot of all RNA transcripts expressed in a cell at a given time. This technology allows us to observe the #immunesystem in unprecedented detail. By analyzing how genes are expressed during an immune response, we gain crucial insights into the mechanisms that drive protection—or, in some cases, lead to adverse reactions. 🔍Why is this important for vaccine development? Transcriptomics helps us identify #biomarkers that predict vaccine efficacy and potential side effects, allowing for early optimization of formulations. By understanding which genes are activated during an immune response, we can design vaccines that offer better protection and longer-lasting immunity. This deeper insight also accelerates the development process, bringing new vaccines to patients faster. As the biotech and pharma industries evolve, integrating transcriptomics into #vaccinedevelopment isn't just a forward-thinking strategy—it's becoming essential. By embracing this technology, we can create the next generation of vaccines that are safer, more effective, and better suited to tackle emerging health threats. Let’s leverage the full potential of transcriptomics to stay ahead in the fight against infectious diseases. The future of vaccine development is here—Are you ready to be a part of it? Curious to learn more? Check out our blog, "Accelerating Vaccine Development with Transcriptomics," to understand how this powerful tool is transforming the future of #immunology. https://bit.ly/3XivSCO

👀 Discover more about HypoSkin®, the unique injectable ex vivo human skin model! 💊 HypoSkin is perfect for various applications including drug metabolism and biodistribution studies, bolus of injection analysis, medical device testing, radiochemical studies, and testing of therapeutics against infectious diseases. 💉 HypoSkin can be used to study the effect of subcutaneous, intradermal, or transdermal injections of biologics, vaccines, and small molecules on humans and to ensure the compatibility and safety of medical devices. 🛠️ Genoskin offers comprehensive tools to assist customers in initiating their own HypoSkin studies. The User Manual includes detailed descriptions of the HypoSkin model, available formats for various administrations, and a step-by-step guide for kit setup, compound administration, culturing, and biopsy collection. Download our user manual now! https://bit.ly/47gmVyn

🌟 Spotlight on Injection Site Reactions (ISRs): Understanding Mast Cell Involvement 🌟 Did you know that mast cells play a critical role in the development of ISRs, including pain and inflammation at injection sites? The MrgprX2 receptor on mast cells, when activated by certain molecules like neuropeptides and antibiotics, triggers the rapid release of inflammatory mediators such as histamine and tryptase. This leads to edema, redness, and the pain/itch sensation that often accompanies injections. With ImmunoSafe, we harness our cutting-edge platform to assess these reactions using real human skin models, providing insights that closely mimic actual human responses. If you're looking to de-risk your injectable therapeutics development, explore how this platform can help you predict and mitigate ISRs effectively. 👉 Discover more about our ImmunoSafe: ISR Platform® and ensure the safety of your next therapeutic: Visit our product page now! https://bit.ly/4eaoXSL #DrugDevelopment #ImmunoSafe #InjectionSiteReactions #Biotech #Pharma #MastCells #MrpgrX2 #SafetyFirst #Innovation

💉Advancing Vaccine Development with Cutting-Edge Research At Genoskin, we aim to pioneer the future of vaccine development by leveraging our innovative human skin models to offer valuable insights into how vaccines interact with the human immune system. This approach allows for a more accurate and detailed analysis compared to traditional methods, bridging the gap between preclinical studies and real-world human responses. Discover more about our vaccine development research with our poster titled “High-dimensional profiling of immune response to vaccines using bio-stabilized and injectable natural human skin.” This research is a step forward in refining vaccine development, contributing to safer and more effective outcomes. 👉 Download the poster here: https://bit.ly/4dGmqzY #VaccineDevelopment #Immunology

Revolutionizing Skin Cancer Diagnosis with Wearable Bioelectronics! We are thrilled to highlight an innovative study by our client at Karolinska Institutet showcasing a breakthrough in skin cancer diagnostics using a wearable bioelectronic patch for transdermal sensing of melanoma biomarkers. Their research showcases the potential of wearable bioelectronics in revolutionizing melanoma detection. By utilizing Genoskin's advanced human skin models, they've developed a microneedle patch capable of accurately sensing the melanoma biomarker, tyrosinase. This innovative approach marks a significant step forward in early-stage cancer diagnosis. Key highlights include: 👉 Sensing: The microneedle sensor allows for non-invasive, real-time monitoring of Tyr levels directly from the skin. 👉 Ex Vivo Human Skin Models: Utilizing NativeSkin® models, the study ensured realistic and accurate testing conditions, paving the way for clinical applications. 👉 Wearable Technology: The device offers a minimally disruptive means for continuous surveillance and timely intervention of skin anomalies, with potential applications extending to other skin conditions like inflammatory skin diseases and allergies. This groundbreaking approach could revolutionize skin health monitoring, providing clinicians and patients with a reliable tool for early melanoma detection and personalized healthcare. Check out the full publication to dive deeper into the methodology and findings: https://lnkd.in/e6uCQAAu #WearableTech #Bioelectronics #SkinCancer #Melanoma #SkinCancerDiagnosis

🔬 Exploring Vaccine-Induced Immune Responses 🔬 We’re excited to spotlight the groundbreaking #research that our Scientist, Manon Scholaert, will be presenting at the 7th European Congress of Immunology 2024 in Dublin! Her presentation, titled “Multimodal and Longitudinal Single-Cell Analysis of Local Innate Immune Response to Vaccine in Ex Vivo Natural Human Skin Modules,” offers three critical takeaways: 1️⃣ Single-Cell Resolution: Utilizing HypoSkin® models, we’ve achieved unprecedented insights into mRNA vaccine-induced #immuneresponses at the injection site. 2️⃣ Spatial Imaging: MANTIS® technology reveals key activation and redistribution of antigen-presenting cells, providing insights into cell distribution in the skin following injection. 3️⃣ Innate Immunity Insights: Our findings show the pivotal role of dendritic cells, macrophage and mast cell clusters in responding to SARS-CoV-2 spike mRNA post-injection. Don't miss Manon's session on Monday, September 2nd, from 15:55 to 17:10 in Room 08, LIFFEY MEETING ROOM 2. Explore our research further and discover how these insights are shaping the future of #vaccinedevelopment. For more information on our research 👉 https://lnkd.in/eHU87x7n

🎥 Unlock the Secrets of Vaccine Response! Join our Chief Scientific Officer, Dr. Nicolas Gaudenzio, as he guides you through our groundbreaking research:"Multimodal profiling of biostabilized human skin modules reveals a coordinated ecosystem response to injected mRNA-1273 COVID19 vaccine”, published in Allergy EAACI. In this video, Nicolas breaks down how our innovative ex vivo human skin models reveal the intricate dance of the immune system when exposed to the mRNA-1273 COVID-19 vaccine. It’s a must-watch for anyone interested in vaccine research. 👉Dive into the science and watch the full video here: https://lnkd.in/eTjHyzBq #VaccineResearch #Immunology #COVID19Vaccine #Genoskin #ScientificInnovation

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