INNOPSYS

Check this out! https://bit.ly/4eBm3ai

Highly Sensitive 3D-Nanoplasmonic-Based Epidermal Growth Factor Receptor Mutation Multiplex Assay Chip for Liquid Biopsy Epidermal growth factor receptor (EGFR) mutations are critical biomarkers for lung cancer, found in over 50% of patients. Current detection methods, such as direct sequencing and next-generation sequencing (NGS), often have low sensitivity, leading to potentially inaccurate results. A 3D-nanoplasmonic-based EGFR mutation multiplex microarray assay was designed which achieves an exceptional sensitivity of 1 × 10⁻⁹% mutant frequency, significantly surpassing previous detection methods that had sensitivities ranging from 0.01% to 1%. The assay can identify deletions,insertions and mutation within the target region using a single chip with plasma ctDNA , enhancing clinical sensitivity while being cost-effective. Additionally, the assay chip can be adapted for detecting various cancer biomarkers, making it a versatile tool in clinical settings. The InnoScan 710 microarray scanner plays a crucial role in the assay by enabling the detection of fluorescence signals from the hybridized chip, allowing for the quantification of fluorescent signals that correspond to the presence of specific EGFR mutations. Original publication :  https://lnkd.in/eskQFUp8 #EGFRMutations #3DNanoplasmonicAssay #LiquidBiopsy #FluorescenceDetection

Less than 2 weeks!! We are so excited to show you #InnoQuant at the #KIT campus and let you experience how it can simplify the way of imaging in your lab!! There are still free time slots for your samples -> get in touch with me for registration 💡

See our website for complete information: https://bit.ly/4eBm3ai

📢 Welcome to our booth #668, the team Perrine Borel, Joséphine Zeiger, Robert Meyer will be pleased to demo InnoQuant, our unique quantitative fluorescence scanner. 😀

😀 Exciting news from neuroscience 2024!

Join me at the Society for Neuroscience in Chicago, October 5-9, at McCormick Place Convention Center. Discover a unique approach to whole slide imaging : large width laser scanning, inherent optical sectionning, 4 colors in just one pass, and no field-of-view 😯 Don't miss out on valuable connections with INNOPSYS team : Laurence Bouet, Joséphine Zeiger. #SfN, #WholeSlide, #FluorescenceMicroscopy, #Automation

We are excited to announce that Innopsys will be attending Neuroscience 2024! Meet our experts Laurence Bouet, Perrine Borel and Joséphie Zeiger to discover our latest innovations in neuroscience research solutions. Don’t miss out, come and visit us at booth #668! 📅 October 5-9, 2024 📍 Chicago, Booth #668

A comprehensive synthetic library of poly-Nacetyl glucosamines enabled vaccine against lethal challenges of Staphylococcus aureus Bacterial infections pose a significant threat to global health, worsened by the rise of antimicrobial-resistant strains. This situation underscores the urgent need for new prevention and treatment strategies, including vaccines. While vaccines exist for some pathogens, there are currently no approved vaccines for many deadly bacteria, including Staphylococcus aureus (S. aureus). The polysaccharide poly-β-(1–6)-N-acetylglucosamine (PNAG), found in the cell walls of S. aureus and other pathogens, is a promising antigen for vaccine due to its role in immune evasion. PNAG exhibits structural variability, with differing degrees of free amines and N-acetamides, complicating the identification of optimal vaccine epitopes. A comprehensive library of 32 PNAG pentasaccharides with all combinations of free amines and N- acetamides are synthesized and fabricated into a microarray chip. InnoScan 1100 AL was utilized to analyze the binding of anti-PNAG monoclonal antibody (mAb F598, isolated from a patient who recovered from an S. aureus infection) to differentiate PNAG variants on the microarray chip, helping to identify which structures elicited the strongest immune responses to guide the design of effective vaccine candidates. Original publication :  https://lnkd.in/e5589h5Z #Glycan #Epitope #Vaccine #Staphylococcusaureus

Potential pandemic risk of circulating swine H1N2 influenza viruses Influenza A viruses in swine have considerable genetic diversity and continue to pose a pandemic threat to humans due to a potential lack of population level immunity. Swine origin α -swH1N2 virus replicates efficiently in human airway cultures and exhibits phenotypic signatures similar to the human H1N1 pandemic strain from 2009. Glycan array and InnoScan 1100AL scanner are used for analyzing receptor specificity of α -swH1N2 virus, which is crucial for understanding how viruses interact with host receptors and can inform assessments of their transmissibility and potential pandemic risk. The array result show α-swH1N2 virus exhibits a receptor specificity well adapted for human-type receptors. Original publication : https://lnkd.in/e4NciMaS #SwineH1N2influenzaviruses #Glycanarray #Hostspecificity