💥 Catch us at #ACS Fall in #Denver, Booth #1923! Let’s discuss with Marc Janes, Gavin Magnuson, Ryan Simard and Jonathan Shannon how our cutting-edge solutions can advance your research. ❓Not attending? Download our latest #poster showcasing our synthesis of betsylated amino acids using aqueous buffered sodium hypochlorite solution - a testament to our #chemistry #expertise supporting our #peptide platform. 👉 https://lnkd.in/e_QFyvCJ Explore the science behind this breakthrough and discover more about NuChem Sciences & Sygnature Discovery #CRO #DrugDiscovery - American Chemical Society 💥 Retrouvez-nous à l'#ACS Fall à #Denver, au stand #1923 ! Discutez avec Marc Janes, Gavin Magnuson, Ryan Simard et Jonathan Shannon de la manière dont nos solutions de pointe peuvent faire progresser vos recherches. ❓Vous ne participez pas à l'événement ? Téléchargez notre dernier #poster mettant en avant notre synthèse d'acides aminés betsylés à l'aide d'une solution aqueuse d'hypochlorite de sodium tamponnée - un témoignage de notre expertise en chimie sur laquelle s'appuie notre plateforme pour la chimie des peptides. 👉 https://lnkd.in/e_QFyvCJ Explorez la science derrière cette percée et découvrez-en plus sur NuChem Sciences & Sygnature Discovery.
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Consultant en biotechnologie pour Agilent Technologies, Laboratory Solution Sales (LSS) | Biotechnical Consultant for Agilent Technologies, Laboratory Solution Sales (LSS)
Simplifiez le développement de méthodes lors de la mise à l’échelle de l’analytique à la purification avec les dimensions scalaires, semi-préparatives et préparatives d’oligonucléotides AdvanceBio et obtenez une purification à haut rendement. https://bit.ly/3VafVyE #AdvanceBio #oligonucleotide #oligonucléotide
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It's that time of the week again where we ask '𝙝𝙤𝙬 𝙬𝙚𝙡𝙡 𝙙𝙤 𝙮𝙤𝙪 𝙠𝙣𝙤𝙬 𝙮𝙤𝙪𝙧 𝙖𝙢𝙞𝙣𝙤 𝙖𝙘𝙞𝙙𝙨?'. In the last instalment, we looked into some less obvious aspects of #asparticacid. This week our brilliant postdoc student Jolien offers some fascinating trivia about #tyrosine!! 😁🫀 We are quite sure this is an amino acid close to her heart... 🤓 Do you know another interesting fact bout tyrosine that people should know? Share it with us! Otherwise, tune back in next week for hashtag #AminoAcidoftheWeek (#AAOTW) 😉 #vub #wearevub #medicinalchemistry #drugdesign #peptides #chemistry #aminoacid #aminoacids #peptidechemistry
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Congratulations to the researchers of Synthesis of chiral 2-(N-Boc-azetidin-3-yl)-2-alkylpropanoic acids as novel GABA derivatives for their protocol which describes a simple access to chiral 2-(N-Boc-azetidin-3-yl)-2-alkylpropanoic acids as new GABA derivatives. Azetidine carboxylic acids serve as building blocks to produce various peptides, as they are important heterocyclic amino acids with many interesting biological activities. For example, one type inhibits the growth of E. coli and various seedlings. Based on their spectroscopic data, the structures of the 2-(N-Boc-azetidin-3-yl)-2-alkylpropanoic acids were established. We are glad that the researchers involved our UniPol L to determine the optical rotation. Here you can find the document: https://buff.ly/3T5vS8b Here you can find our new UniPol V: https://buff.ly/3Gm0xqO Wishing you continued success in your research and discoveries! #SchmidtHaensch #Alkylpropanoicacids #Application
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Consultant en biotechnologie pour Agilent Technologies, Laboratory Solution Sales (LSS) | Biotechnical Consultant for Agilent Technologies, Laboratory Solution Sales (LSS)
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CEM Corporation propose la synthèse peptidique sans phases de lavage sur les instruments Liberty Blue 2.0 et Liberty Prime 2.0 : https://bit.ly/LibertyBlue Pour une qualité de peptides inchangée, ce procédé permet jusqu’à 95% de déchets de lavage en moins. Ainsi, un cycle dure moins de 4 minutes et les Liberty vous donnent la possibilité de réaliser jusqu'à 24 synthèses en séquentiel. #PeptideSynthesis #SynthesePeptidique #UESPPS #NoWash #NoWashTechnology #Peptides #GreenTechnology #SustainableChemistry
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In this application note, an amino acid composition analysis of semaglutide and liraglutide was conducted using an Agilent AdvanceBio Amino Acid Analysis (AAA) LC column and an Agilent 1260 Infinity II Prime bio LC system. The precolumn derivatization with ortho-phthalaldehyde (OPA) allowed straightforward and reliable quantification. Notably, 2-aminoisobutyric acid present in semaglutide was accurately quantified. Learn more : https://lnkd.in/dzqq4RQk
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Senior Physiologist | Anti-Aging & Longevity Specialist | Nutrition & Hormonal Biology Expert | Nutrigenetic & AI
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MOLECULE OF THE MONTH 📣 Copper-mediated 18F-radiofluorination has been extended to the use of arylstannanes as precursors [1]. This method can be used for the 18F-radiosynthesis of [18F]F-L-DOPA under mild conditions and represents a valuable alternative to the technically sophisticated and low-yielding electrophilic approach. Automated 18F-radiofluorination of the TetraBoc protected trimethyltin precusor for clinical use was performed with a radiochemical purity of >99% and a molar activity of up to 60 GBq/µmol [2]. Find the products (prod no. 1345 and 1310) at abx.de and send us your quote request today! [1] Makaravage K. J. et al. Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF. Org. Lett. 2016, 18, 5440-5443; Zarad F. et.al. A Practical Method for the Preparation of 18F-Labeled Aromatic Amino Acids from Nucleophilic [18F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation. Molecules 2017, 22, 2231. [2] Kniess T. et al. Cu-mediated 18F-radioflourination of various stannylated FDOPA precursors - what is feasible? Poster iSRS 2023, Honolulu, Hawaii.
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One of the main drawbacks of classic peptide synthesis is the need for protecting groups. But what if you could perform amino acid coupling without any (de)protection? In an article by Tomohiro Hattori and Hisashi Yamamoto, they describe a process that could be considered in-situ protection-activation of amino acids, leading to highly selective coupling between two amino acids. P.S. Even heptapeptide synthesis is possible! and >20:1 dr https://lnkd.in/efzajSJt
Peptide Bond Formation Between Unprotected Amino Acids: Convergent Synthesis of Oligopeptides
pubs.acs.org
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Consultant en biotechnologie pour Agilent Technologies, Laboratory Solution Sales (LSS) | Biotechnical Consultant for Agilent Technologies, Laboratory Solution Sales (LSS)
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VP Hit ID Technologies at Sygnature Discovery
2 moisA really nice route to generate these orthogonally protected amino acids.