es/iode

🚀 New ES/IODE Update! 🎉 We are excited to announce the release of version 3.5.2 with several enhancements to provide an optimized user experience: 🔍 Advanced Search: Configuration buttons are now embedded in the search bar for scientific articles and clinical trials. 🔐 GDPR Compliance: A new option in the user menu allows you to download or delete your personal data and account. 🌐 New Homepage: Added images and scrolling animations for smoother navigation. 📊 Infrastructure Status: Track the real-time status of our infrastructure via a link in the footer. Discover these new features now on ES/IODE! #update #technews #ESIODE #innovation

📃Scientific paper: The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review Abstract: As warned by Sir Alexander Fleming in his Nobel Prize address: “the use of antimicrobials can, and will, lead to resistance”. Antimicrobial resistance (AMR) has recently increased due to the overuse and misuse of antibiotics, and their use in animals (food-producing and companion) has also resulted in the selection and transmission of resistant bacteria. The epidemiology of resistance is complex, and factors other than the overall quantity of antibiotics consumed may influence it. Nowadays, AMR has a serious impact on society, both economically and in terms of healthcare. This narrative review aimed to provide a scenario of the state of the AMR phenomenon in veterinary medicine related to the use of antibiotics in different animal species; the impact that it can have on animals, as well as humans and the environment, was considered. Providing some particular instances, the authors tried to explain the vastness of the phenomenon of AMR in veterinary medicine due to many and diverse aspects that cannot always be controlled. The veterinarian is the main reference point here and has a high responsibility towards the human–animal–environment triad. Sharing such a burden with human medicine and cooperating together for the same purpose (fighting and containing AMR) represents an effective example of the application of the One Health approach. Continued on ES/IODE ➡️ https://etcse.fr/lt05 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Hereditary spastic paraparesis type 18 (SPG18): new ERLIN2 variants in a series of Italian patients, shedding light upon genetic and phenotypic variability Abstract: Introduction Hereditary spastic paraparesis (HSP) is a group of central nervous system diseases primarily affecting the spinal upper motor neurons, with different inheritance patterns and phenotypes. SPG18 is a rare, early-onset, complicated HSP, first reported as linked to biallelic ERLIN2 mutations. Recent cases of late-onset, pure HSP with monoallelic ERLIN2 variants prompt inquiries into the zygosity of such genetic conditions. The observed relationship between phenotype and mode of inheritance suggests a potential dominant negative effect of mutated ERLIN2 protein, potentially resulting in a milder phenotype. This speculation suggests that a wider range of HSP genes could be linked to various inheritance patterns. Purpose and background With documented cases of HSP loci exhibiting both dominant and recessive patterns, this study emphasizes that the concept of zygosity is no longer a limiting factor in the establishment of molecular diagnoses for HSP. Recent cases have demonstrated phenoconversion in SPG18, from HSP to an amyotrophic lateral sclerosis (ALS)-like syndrome. Methods and results This report highlights two cases out of five exhibiting HSP-ALS phenoconversion, discussing an observed prevalence in autosomal dominant SPG18. Additionally, the study emphasizes the relatively high incidence of the c.502G>A variant in monoallelic SPG18 cases. This mutation appears to be particularly common in cases of HSPALS phenoconversion, indicating its potential role a... Continued on ES/IODE ➡️ https://etcse.fr/1nc ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #amyotrophiclateralsclerosis #als #charcot

📃Scientific paper: Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca(2+) Entry Pathway Abstract: PURPOSE: Increased evidence has shown that aerobic exercise reduces airway hyperresponsiveness in asthmatic individuals. However, the underlying mechanisms of action remain elusive. This study aimed to investigate the effect of exercise on airway smooth muscle (ASM) contractile function in asthmatic rats, and uncover the possible involvement of interleukin 4 (IL-4) and the store-operated Ca(2+) entry (SOCE) pathway. METHODS: In this study, chicken ovalbumin was used to induce asthma in male Sprague-Dawley rats. The exercise group received moderate-intensity aerobic exercise training for 4 weeks. IL-4 concentrations in bronchoalveolar lavage fluid (BALF) samples were evaluated by enzyme linked immunosorbent assay. The contractile function of the ASM was investigated using tracheal ring tension experiments and intracellular Ca(2+) imaging techniques. Western blot analysis was used to evaluate expression levels of calcium-release activated calcium (CRAC) channel protein (Orai) and stromal interaction molecule 1 (STIM1) in ASM. RESULTS: Our data showed that the carbachol-stimulated, SOCE-mediated contraction of rat ASM was significantly increased in asthmatic rats, which could be abolished by exercise. Pharmacological studies revealed that GSK5498A and BTP-2, selective blockers of CRAC channels significantly inhibited SOCE-induced ASM contraction. In addition, exercise inhibited the up-regulation of IL-4 in BALF as well as STIM1 and Orai expression in the ASM of asthm... Continued on ES/IODE ➡️ https://etcse.fr/IQfd ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

• Study: Development and Validation of Quality of Life in Parkinson's Disease Instrument Ref.: Medknow Publications & Media Pvt Ltd, 2020 Link: https://etcse.fr/0GQx ━━━━━━━━━━━━━━━━━━━━━━ 13. Mycology ━━━━━━━━━━━━━━━━━━━━━━ • Study: Effects of sweet potato intercropping in banana orchard on soil microbial population diversity Ref.: BioMed Central, 2023 Link: https://etcse.fr/yHdm1 ━━━━━━━━━━━━━━━━━━━━━━ 14. Veterinary ━━━━━━━━━━━━━━━━━━━━━━ • Study: The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review Ref.: MDPI, 2023 Link: https://etcse.fr/lt05 ━━━━━━━━━━━━━━━━━━━━━━ 15. AmyotrophicLateralSclerosis ━━━━━━━━━━━━━━━━━━━━━━ • Study: Hereditary spastic paraparesis type 18 (SPG18): new ERLIN2 variants in a series of Italian patients, shedding light upon genetic and phenotypic variability Ref.: Springer, 2024 Link: https://etcse.fr/1nc ━━━━━━━━━━━━━━━━━━━━━━ 16. Allergology ━━━━━━━━━━━━━━━━━━━━━━ • Study: Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca(2+) Entry Pathway Ref.: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2023 Link: https://etcse.fr/IQfd 🔗 To explore more studies and discover the full findings: https://lnkd.in/eBsz32Di ------- If you found this report insightful, feel free to follow, comment, and share. We appreciate your support in helping us grow our visibility and continuing to serve the scientific community.

🌐 Daily Report – Scientific Selection by ES/IODE 🔬 Today’s report showcases selected studies from various scientific domains. These findings offer fresh insights and drive innovation in key areas of science, health, and technology: ━━━━━━━━━━━━━━━━━━━━━━ 1. Cancer ━━━━━━━━━━━━━━━━━━━━━━ • Study: Evaluation of Entropy and Fractal Dimension as Biomarkers for Tumor Growth and Treatment Response using Cellular Automata Ref.: 2022 Link: https://etcse.fr/6xRP ━━━━━━━━━━━━━━━━━━━━━━ 2. Covid ━━━━━━━━━━━━━━━━━━━━━━ • Study: Long COVID clinics and services offered by top US hospitals: an empirical analysis of clinical options as of May 2023 Ref.: BioMed Central, 2024 Link: https://etcse.fr/ytpa ━━━━━━━━━━━━━━━━━━━━━━ 3. Sport ━━━━━━━━━━━━━━━━━━━━━━ • Study: GATCDA: Predicting circRNA-Disease Associations Based on Graph Attention Network Ref.: MDPI, 2021 Link: https://etcse.fr/UBqH ━━━━━━━━━━━━━━━━━━━━━━ 4. Hiv ━━━━━━━━━━━━━━━━━━━━━━ • Study: Measuring intersectional HIV, sexual diversity, and gender non-conformity stigma among healthcare workers in Ghana: scale validation and correlates of stigma Ref.: BioMed Central, 2024 Link: https://etcse.fr/wmuO ━━━━━━━━━━━━━━━━━━━━━━ 5. Alzheimer ━━━━━━━━━━━━━━━━━━━━━━ • Study: Stress and the risk of Alzheimer dementia: Can deconstructed engrams be rebuilt? Ref.: HAL CCSD;Wiley, 2023 Link: https://etcse.fr/6drlv ━━━━━━━━━━━━━━━━━━━━━━ 6. Thyroid ━━━━━━━━━━━━━━━━━━━━━━ • Study: Revolutionary multi-omics analysis revealing prognostic signature of thyroid cancer and subsequent in vitro validation of SNAI1 in mediating thyroid cancer progression through EMT Ref.: Springer, 2024 Link: https://etcse.fr/uKHi ━━━━━━━━━━━━━━━━━━━━━━ 7. ComputerScience ━━━━━━━━━━━━━━━━━━━━━━ • Study: Three-Dimensional Amyloid-Beta PET Synthesis from Structural MRI with Conditional Generative Adversarial Networks Ref.: 2024 Link: https://etcse.fr/mbse ━━━━━━━━━━━━━━━━━━━━━━ 8. SciencesUniverse ━━━━━━━━━━━━━━━━━━━━━━ • Study: A numerical simulation study of an astrometry case for MORFEO at the ELT Ref.: 2024 Link: https://etcse.fr/5OhcQ ━━━━━━━━━━━━━━━━━━━━━━ 9. Urology ━━━━━━━━━━━━━━━━━━━━━━ • Study: Design and utilisation of a novel, high-fidelity, low-cost, hybrid-tissue simulation model to facilitate training in robot-assisted partial nephrectomy Ref.: Springer, 2024 Link: https://etcse.fr/T0j ━━━━━━━━━━━━━━━━━━━━━━ 10. Neurosciences ━━━━━━━━━━━━━━━━━━━━━━ • Study: Reelin Signaling Pathway and Mesial Temporal Lobe Epilepsy: A Causative Link Ref.: Iranian Neuroscience Society, 2023 Link: https://etcse.fr/CdfZG ━━━━━━━━━━━━━━━━━━━━━━ 11. Influenza ━━━━━━━━━━━━━━━━━━━━━━ • Study: Case report: the management for a gestational hypertensive woman with influenza A virus pneumonia and peripartum cardiomyopathy Ref.: BioMed Central, 2022 Link: https://etcse.fr/BKof ━━━━━━━━━━━━━━━━━━━━━━ 12. Parkinson ━━━━━━━━━━━━━━━━━━━━━━

📃Scientific paper: Design and utilisation of a novel, high-fidelity, low-cost, hybrid-tissue simulation model to facilitate training in robot-assisted partial nephrectomy Abstract: Robot-assisted partial nephrectomy (RAPN) has rapidly evolved as the standard of care for appropriately selected renal tumours, offering key patient benefits over radical nephrectomy or open surgical approaches. Accordingly, RAPN is a key competency that urology trainees wishing to treat kidney cancer must master. Training in robotic surgery is subject to numerous challenges, and simulation has been established as valuable step in the robotic learning curve. However, simulation models are often both expensive and suboptimal in fidelity. This means that the number of practice repetitions for a trainee may limited by cost restraints, and that trainees may struggle to reconcile the skills obtained in the simulation laboratory with real-world practice in the operating room. We have developed a high-fidelity, low-cost, customizable model for RAPN simulation based on porcine tissue. The model has been utilised in teaching courses at our institution, confirming both feasibility of use and high user acceptability. We share the design of our model in this proof-of-concept report. Continued on ES/IODE ➡️ https://etcse.fr/T0j ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Revolutionary multi-omics analysis revealing prognostic signature of thyroid cancer and subsequent in vitro validation of SNAI1 in mediating thyroid cancer progression through EMT Abstract: Thyroid carcinoma (TC), the most commonly diagnosed malignancy of the endocrine system, has witnessed a significant rise in incidence over the past few decades. The integration of scRNA-seq with other sequencing approaches offers researchers a distinct perspective to explore mechanisms underlying TC progression. Therefore, it is crucial to develop a prognostic model for TC patients by utilizing a multi-omics approach. We acquired and processed transcriptomic data from the TCGA-THCA dataset, including mRNA expression profiles, lncRNA expression profiles, miRNA expression profiles, methylation chip data, gene mutation data, and clinical data. We constructed a tumor-related risk model using machine learning methods and developed a consensus machine learning-driven signature (CMLS) for accurate and stable prediction of TC patient outcomes. 2 strains of undifferentiated TC cell lines and 1 strain of PTC cell line were utilized for in vitro validation. mRNA, protein levels of hub genes, epithelial-mesenchymal transition (EMT)-associated phenotypes were detected by a series of in vitro experiments. We identified 3 molecular subtypes of TC based on integrated multi-omics clustering algorithms, which were associated with overall survival and displayed distinct molecular features. We developed a CMLS based on 28 hub genes to predict patient outcomes, and demonstrated that CMLS outperformed other prognostic models. TC patients of relatively lower CMLS score had significantly ... Continued on ES/IODE ➡️ https://etcse.fr/uKHi ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: GATCDA: Predicting circRNA-Disease Associations Based on Graph Attention Network Abstract: SIMPLE SUMMARY: CircRNAs (circular RNAs), a novel kind of non-coding RNAs, play a regulatory role in cellular processes. A growing number of biological experiments has proved that circRNAs can be used as biomarkers and therapeutic targets of some cancers. As the time and financial costs of biological experiments are high, computational methods have become a better way to predict the associations between circRNAs and diseases. Graph attention network was first applied to predict circRNA-disease associations with multiple similarities of data in this study. The circRNA–miRNA interactions and disease-mRNA interactions were adopted to construct features. The computational method proposed in this study has improved the prediction performance. ABSTRACT: CircRNAs (circular RNAs) are a class of non-coding RNA molecules with a closed circular structure. CircRNAs are closely related to the occurrence and development of diseases. Due to the time-consuming nature of biological experiments, computational methods have become a better way to predict the interactions between circRNAs and diseases. In this study, we developed a novel computational method called GATCDA utilizing a graph attention network (GAT) to predict circRNA–disease associations with disease symptom similarity, network similarity, and information entropy similarity for both circRNAs and diseases. GAT learns representations for nodes on a graph by an attention mechanism, which assigns different weights to differ... Continued on ES/IODE ➡️ https://etcse.fr/UBqH ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: A numerical simulation study of an astrometry case for MORFEO at the ELT Abstract: We report results from numerical simulations assessing astrometry measurements with the Multiconjugate Adaptive Optics Relay for ELT Observations \(MORFEO\) instrument on the Extremely Large Telescope \(ELT\). Using the Advanced Exposure Time Calculator \(AETC\), we evaluate MORFEO astrometric accuracy in moderately crowded fields. Our simulations account for spatially variable Point Spread Function \(PSF\), geometric distortion, and rotation-dependent variations. We computed focal plane coordinates using observed stellar distribution and computed population synthesis with the SPISEA tool, generating stellar magnitude distributions for MICADO filters at selected metallicities and stellar ages. Our analysis shows that MORFEO can achieve high-precision astrometry in the galaxy neighborhood \(within $\mu \< 24$ mag\) by minimizing PSF enlargement and optimizing calibration strategies. These results inform future observational campaigns and contribute to the development of astrometric science cases for the ELT. ;Comment: 7 pages, 6 figures, Proceeding for SPIE Astronomical Telescopes + Instrumentation, Adaptive Optics Systems IX, 16-21 June 2024 Continued on ES/IODE ➡️ https://etcse.fr/5OhcQ ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.