STEREOTACTIC RADIOSURGERY (SRS) for INTRACRANIAL CAVERNOUS MALFORMATIONS: International Stereotactic Radiosurgery Society (ISRS), Systematic Review, Meta-Analysis, and PRACTICE GUIDELINES
Salem M Tos et al., World Neurosurg., 2024 Sep 26
https://lnkd.in/dWSuvad6
32 studies with 2672 patients with intracranial cavernous malformations treated with single fraction SRS
- a significant DECREASE in ANNUAL HEMORRHAGE RATES was observed post-treatment:
*RISK RATIO=O.29 in the first 2 years
*RISK RATIO=0.11 after the fisrt 2 years
- among EPILEPTIC patients, 49.9% were SEIZURE-FREE post-SRS, while 30.6% experienced reduced seizure frequency
- among EPILEPTIC patients, 30.6% experienced REDUSED SEIZURE FREQUENCY
- lesion VOLUME changes showed:
*REDUCTION in 46.9%
*STABILITY in 47.1%
*INCREASE in 6.7%
- radiation induced TOXICITY affected 8% of patients
- SYMPTOMATIC CHANGE RATES of 6% at doses ≤13Gy compared to 9% at doses >13Gy
CONCLUSION: This meta-analysis suggests SRS is an EFFECTIVE intervention for intracranial cavernous malformations, significantly REDUCING HEMORRHAGE RATES and IMPROVING SEIZURE OUTCOMES.
ISRS PRACTICE GUIDELINES are provided.
#SRS #IntracranialCavernousMalformations #ISRS #PracticeGuideline