DeltaBio

Five Hungarian biotech companies are introducing at Global Bio India 2024 in Pragati Maidan New Delhi 12-14 September! Please visit us! jFermi Biotechnology Kft. DeltaBio waterandsoil Proofminder Balázs Tallós Szabolcs Petri Richard Vattay Biotechnology Industry Research Assistance Council (BIRAC) Global Business Inroads (GBI) Harsha Lingam Peeush Srivastava Lajos Pinter Norbert Havas Shradha Ganeriwala Elene Lomadze

We’ve analyzed over 7,000 gut microbiome samples. Here are the top 3 things we’ve learned. 1. If you’re not feeling well but don’t know why – check your gut bacteria. Countless health conditions are connected to your gut. Apart from the obvious (like IBS, IBD, bloating, diarrhea, or indigestion). Conditions such as: • Anxiety… • Fatigue… • Allergies… • Diabetes… • Depression… • Autoimmune disorders… • Or inability to lose weight… …can potentially all be tied to your gut. So, in many cases... Restoring your gut’s healthy balance can alleviate your symptoms or even help treat the disease itself. But to do so, you first need to understand the current state of your gut flora… 2. Gut microbiome analysis can transform healthcare As we learn more about how our gut bacteria impacts our healths… …we’re also paving the way for new ways to diagnose & treat diseases. So, our hope is that by using our microbiome tests, doctors will soon be able to: • Identify specific microbial patterns as biomarkers ↳ for early disease detection & prevention. • Stratify patients based on their microbial profiles ↳ for better personalized treatment strategies. • Monitor microbiome changes during treatment ↳ to optimize interventions & improve outcomes. Currently, we’re still far from maximizing the full potential of our gut microbiome diagnostics. But the future is bright – and we have every reason to be optimistic! 3. You can improve your gut flora without medications In over 90% of cases, we were able to help our customers improve their gut floras naturally. How? First, we identified all bacteria strains & ratios in their samples with our “shotgun” NGS-based diagnostics. Then, we gave them personalized guidance on: • What lifestyle changes to make… • What supplements to take… • What diets to follow… …based on their unique gut microbiome profiles. The result? Over 90% of our customers reported significant improvements in their symptoms, moods, and healths. So while medications do have their place – they’re not always needed to improve your health & well-being. Do you think gut health is getting the attention it deserves? Why? Or why not? Share your thoughts in the comments! 👇 #microbiome #guthealth #personalizedtreatment #biomarkers #biotechnology

Ever wondered how close we are to detecting the recurrence of high-risk, early-stage cancers? Before they become an issue? Well, our team recently attended the reputable Update '24 Symposium organized by MKOT. So, we might be able to shed light on that… Now, ctDNA-testing is already being used to evaluate the effectiveness of certain cancer therapies. For example, the MonarchE trial compared the effectiveness of combined abemaciclib - standard hormone therapy with hormone therapy alone... ...by checking the blood-levels of patients’ ctDNA (as detailed in Professor Sherene Loi’s presentation). But the potential of ctDNA testing goes beyond determining the effectiveness of various treatments. While more research is needed the use of ctDNA testing may also be able to diagnose the return of cancer earlier in high-risk breast cancer patients after surgery. In fact, ctDNA has even been identified as a key biomarker across various tumor types – not “just” breast cancer. This means it can have both a predictive and a prognostic value across a range of tumors – potentially leading to more precise & effective personalized cancer treatments and diagnostics in the future. So, just imagine a world where the early detection of cancer recurrence or metastasis becomes routine with a simple blood test… THAT’S the vision that our team at DeltaBio is striving to turn into reality. #ctdna #oncology #biotechnology #cancerresearch #cancerdiagnostics

Breast cancer = chemotherapy? Doctors have always been at a crossroads with post-surgery, early-stage breast cancer patients. After all, not all breast cancers are aggressive enough to warrant chemotherapy. But before choosing less radical treatments over chemotherapy… ...doctors need to know they're not endangering their patients' lives by doing so. So the question is: how can they know? Enter OncoFREE, a molecular diagnostics test brought to life in collaboration with our partners, DCGen. OncoFREE gives doctors all the necessary insights to make the right treatment decisions – and avoid unnecessary post-surgery chemotherapy. Although OncoFREE is already: • More reliable... • More precise... • And more cost-effective… ...than the current industry standards, we’re ready to take it to the next level! Interested in OncoFREE? – send us a DM to learn more! #cancerdiagnostics #cancerresearch #molecularbiology #breastcancer #biotechnology

Most current cancer treatments have 3 major issues… 1) Non-specific targeting ↳ Damage to healthy tissues leads to side-effects & reduced effectiveness. 2) Low effectiveness ↳ Tumors can develop genetic resistance, leading to proliferation, recurrence, or progression. 3) Nasty side-effects ↳ Decreases the quality of life for patients, while limiting the dose & duration of treatments. But what if we can overcome these challenges with novel therapeutic targets? Well, our team is making significant progress in the field of neoantigen research to do just that! Neoantigens? Yes! These are unique markers on cancer cells, absent from normal tissues. They arise due to mutations in tumor cells – posing as highly specific potential targets for both the immune system and novel therapies. This specificity may lead to treatments that: • Are highly personalized ↳ to the individual’s specific tumor profile. • Have better effectiveness ↳due to targeting tumors specifically. • Come with reduced risks ↳ of off-target effects or collateral damage. To make this possible, we’re currently in the process of: • Identifying specific neoantigens that could be potential therapeutic targets. • Developing methods to identify potent neoantigens from FFPE samples. Can we finally exploit cancers’ hidden weak-spots with neoantigens? – Let us know your thoughts in the comments! 👇 #cancerresearch #mRNA #neoantigens #immunotherapy #biotechnology

Is RNA-research at the brink of revolutionizing cancer treatments? The RNA 2024 annual conference, organized by the The RNA Society, is officially over – and all 1,100+ participants have gone home. But in case you couldn’t make it to the conference… …we’re here to give you the top 3 most promising areas of RNA research for the upcoming years, as well as their implications in the fight against cancer. (We’re grateful to Zoltán Villányi and the University of Szeged for their insider take – since this year, we couldn’t make it either.) #rnaresearch #cancerresearch #personalizedtherapy #molecularbiology #rna

What do all groundbreaking discoveries in molecular biology have in common? They all start with a brilliant idea from a researcher ready to change the world – just like you! But the path to discovery is rarely smooth… After all, cookie-cutter solutions & technologies just aren’t suited for the boldest of ideas & ambitions. So, if you TRULY want to make your mark in molecular biology, your project might require custom genomic solutions… …and a dedicated partner to support you with the right tools, technologies, and expertise to bring it all to life! That's where we come in! As your partners, we can help you: • Set your project up for success with the right research design. • Access (or develop) the tools & technologies needed for your project. • End up with reliable results and in-depth insights ready for publication. Yes, we’re a business… …but at our core, we’re also scientists. This means that every now-and-then, we’re happy to partner with academic research groups on their most exciting projects in fields like: • Genomic studies • Transcriptomics • Metagenomics • Epigenetics Can YOUR research lead to the next great discovery? Send us a message to tell us more about your project today! #molecularbiology #academicresearch #lifesciences #contractresearchorganization #laboratorylife

Can therapies targeting bacteria improve cancer outlooks? Fusobacterium Nucleatum is a bacteria often found in the human gut & oral cavity. But unfortunately – according to a recent review published in Cancer Biology & Therapy by the Taylor & Francis Group – it may contribute to the development, progression, and treatment resistance of various cancers. So, what’s the good news? According to the same study, reducing F. Nucleatum colonization has shown immense promise in slowing tumor growth and improving survival rates in animal studies. Now, this can be done in several ways, such as: • Targeted antibiotic therapy to eliminate F. Nucleatum • Fecal microbiota transplantation to improve gut barrier integrity • Personalized probiotics & prebiotics to decrease F. Nucleatum colonization What’s more, the presence of F. Nucleatum also shows promise as a potential biomarker for early cancer detection and/or cancer risk assessment. This means that advanced NGS-based microbiome diagnostics (such as ours) can potentially become a convenient, accurate, and comfortable tool to screen for a variety of cancers very soon. So, could our gut bacteria hold the keys to revolutionizing cancer diagnostics & treatment? Check out the full article here: https://lnkd.in/dVsd2ZSz #microbiome #guthealth #cancer #diagnostics #cancerresearch

What’s the future of breast cancer monitoring? That’s what our Chief Scientific Officer, Katalin Priskin talked about when she took the stage at the “2. Liquid Biopsy Seminar” organized by Clinomics Europe. Kati introduced BC-Monitor – our custom-developed breast cancer monitoring solution based on liquid biopsy and next-generation sequencing. From a simple blood sample, BC-Monitor analyzes circulating tumor DNA, providing deep insights into the molecular changes of cancer. Ultimately, this helps oncologists to: • Identify the recurrence or metastasis of breast cancer earlier • Monitor the effectiveness of a given breast cancer therapy • Indicate whether it’s time to change to a new therapy • Choose the right therapy for each individual patient As a minimally invasive approach, BC-Monitor allows for more frequent (and more comfortable) monitoring of breast cancers compared to traditional biopsies and imaging techniques. Moreover, BC-Monitor offers an accurate real-time picture of pathological processes at a molecular level – signalling mutations & changes well before clinical progression is evident. Not only does this help doctors make better treatment decisions – but it can also give peace of mind to their patients… #breastcancer #liquidbiopsy #cancerdiagnostics #personalizedmedicine #nextgenerationsequencing

Can childhood asthma originate… from the gut? Childhood asthma is one of the most common chronic illnesses in early life – affecting approximately 300 million children worldwide. The most common symptoms are shortness of breath, wheezing, and coughing. So, naturally, the primary focus of asthma research for many years has been focused on the lungs. But according to a scientific study published in Science Translational Medicine, when it comes to the causes (and possible treatments) of asthma, there may be another area worth exploring... The gut! In the study, researchers found a strong link between early-life gut dysbiosis and the development of childhood asthma. More precisely, they found that a lower percentage of certain strains of gut bacteria – namely: Lachnospira, Veillonella, Faecalibacterium, and Rothia – in the first few months of a child’s life had a high predictive value to the development of asthmatic symptoms a few years later (possibly due to lower levels of intestinal acetate-production). Could this also imply that gut bacteria might play a crucial role in the effective treatment of childhood asthma? While more research is needed to give a definite answer to this question… …discoveries like these highlight the diverse effects our gut bacteria can have on our health & well-being – and the importance of obtaining accurate information about our gut microbiomes. Check out the full article here: https://lnkd.in/du3uRcZZ #microbiome #guthealth #asthma #childhoodasthma #gutbacteria