Genefitletics

I have been educating this for quite sometime now- just by identify composition of gut microbiome or tell you have A. Muciniphila or Bifidobacterium in your gut does not translate into disease modifying interventions. Human body is a sack of biochemical activities which have to work in synchrony to keep your body in homeostasis You really need to measure the chemicals/molecules secreted by your gut microbiome. Different microbes can produce the same chemicals in two different individuals which may cause type 2 diabetes & same microbes may produce different chemicals in two different individuals. We know that gut microbiome is important but by just looking at gut microbiome one cannot claim that we can solve all diseases. We need to look at cellular interactions, genes expressed by gut microbiome, oral, skin, scalp, vaginal microbiome, mitochondrial functions. Just looking at gut microbiome DNA & telling you there is a risk of some disease is absolutely flawed. Human & microbial biochemistry is really complex & I really laugh when these supplement & probiotics companies list some pure play gut microbiome company tests on their website, acting as distributor for these tests & claim that they have the best report in Rs.10,000-15,000 & that their probiotics are based on this test. These probiotics companies have obscure understanding of microbiome biochemistry & just copy some neurotransmitter names & publish on their website, claiming they are telling you potential  for Neurotransmitter, vitamin or SCFA production. Just ask them if they can measure TMAO, PAG, Uric acid , P-cresol & more & they will be blank For these pure play gut testing companies, they may be creating a liability or impacting your brand value by propagating that their probiotics & supplements are based on their test results. Please stop wasting your money on gut microbiome DNA tests which are being sold as FMCG products To understand your biology at the molecular level, you need to focus on  human, microbial & mitochondrial gene expression & biochemical functions, not DNA. https://lnkd.in/gHNCVmUw #DNA #DNAtesting #gutmicrobome #gutmicrobiometests #probiotics Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak

Over 90% of Indians suffer from gum disease & tooth decay. With clear evidence that health of our mouth is connected with overall health & inflammation in the mouth can spread systemically, trigger a wave of chronic health issues including type 2 diabetes, cardiovascular diseases, digestive issues, chronic kidney disease, sexual health & the list goes on. Among many reasons, one of the most neglected areas which is causing a number of systemic health issues are bad oral hygiene. Your mouth & gum lining is the first line of defense of external compounds you feed your biology & toothpaste is something which is the first thing we feed our oral biology with every morning. Unfortunately, the toothpaste ingredients are bent on imbalancing our oral biology, disrupting our oral microbiome & making oral pH acidic, thereby making it a breeding ground for pathogens. Some of the ingredients found in today’s toothpaste that is trigger wave of chronic health conditions include -Fluoride-it is neurotoxins, reduces pH levels, disrupts melatonin production & interferes with thyroid function -SLS- detergent used as a foaming agent( to give toothpaste a foamy structure) which disrupts oral microbiome homeostasis -Artificial sweeteners such as saccharin that reduces oral microbial diversity -parabens and Propylene Glycol that makes pH level acidic & more So what should your toothpaste offer? Primarily it should have hydroxyapatite- natural form of calcium & phosphorus that regulates oral pH & remineralize teeth Your toothpaste should contain Sodium Tripolyphosphate that prevents plaque build up & inhibits biofilm formation. Besides, it should also have polyphenols, antioxidants & many food extracts that are meant to prevent bad breath & suppress the activity of pathogenic oral microbes. While you may not find some of them in current toothpaste brands, hydroxyapatite is a must. https://lnkd.in/gert3gf4 We at Genefitletics analyze your oral biochemistry at molecular level  to discover subtle molecular signals for poor oral health & carve our nutrition program which would include food, supplements, prebiotics & probiotics & food extracts. These food substrates would include a lot of antioxidants & other beneficial compounds that when coupled with hydroxyapatite based toothpaste  is going to regulate & nourish your oral biology. More details here: https://lnkd.in/dJ2HY5y2 Citations https://lnkd.in/gR-qGGdv https://lnkd.in/gPgd-qQC #oralhealth #gumdisease #toothdecay #oralcancer #type2diabetes #cardiovasculardiseases #halitosis Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak

After all the noise about CGM & blood works driven low carb- high protein diets based on population studies, we have another fabricated story I am sure, nowadays your social media would be bombarded with ad that first claim that all carbs spike your glucose &  then they have this magic pill to minimize or suppress the spike Another stupid product to make you feed your biology with synthetic compounds that is going to have collateral damage to your overall metabolic health for years to come. There are multiple gaps in this story & such companies lacks scientific literacy to understand that -Food is a combination of multiple substrates. How our microbiome interacts with each of the substrates matters. -Each individual’s glycemic response is different based on his/her unique biochemistry.This different glycemic response is not only for different foods but for the same food at different time periods. -There is intracellular communication that makes sure that circulating level glucose is cleared from the circulation & transported to the cell for storage or energy. -Just release of insulin does not matter much. Insulin released binds to various receptors on different cells including muscle & fat cells that triggers multiple cellular signaling cascades that communicate with nitric oxide synthase to activate GLUT 4 to go to the cell membrane, binds glucose & transport it inside of the cell . This activation needs a signal- Nitric oxide. Therefore you really need to understand if your body is producing enough nitric oxide in order to regulate your glycemic response. Just knowing the spike of glucose will not help if NO cannot clear it from circulation. Now comes the most important part To make sure that our body is producing enough nitric oxide, we need to maintain our cell structure & fluidity & to do so we have to just follow one thing- have healthy fats in our diet- saturated & monounsaturated fats. Poly unsaturated fats, omega 6 & vegetable oils are perfect recipe for type 2 diabetes as they can react with oxygen & cause oxidative stress which can oxidize tetrahydrobiopterin( cofactor of eNOS to produce nitric oxide). This shuts down nitric oxide production which cannot activate GLUT 4, thereby causing hyperglycemia, hyperinsulinemia & type 2 diabetes This one small post explains the entire biochemistry behind onset & progression of type 2 diabetes All these supplements & misinformation are meant to keep you sick https://lnkd.in/gWKapRnw #type2diabetes #nitricoxide #insulinresistance #healthyfats Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak

Do you suffer from bloating quite often ? Even after resorting to standard OTC Probiotics or gut microbial DNA tests your bloating does not seem to go away?Probably, you are not addressing the underlying cause While the chemicals secreted by gut microbiomes do have a role to play in our digestive health, the microbes living in our mouth are equally important. In Fact, oral microbes influence a lot of gut microbial activities. Oral microbes via saliva which we swallow every day( 1.5 liters), could transit to the gut. When oral microbiome is imbalanced, certain pathobionts could move to gut & trigger wave of systemic inflammation, thereby increasing risk of digestive issues such as bloating, constipation & could even cause IBD While the world is too obsessed about gut microbiome  composition, we at Genefitletics have adopted a system biology approach that goes beyond DNA & looks at both oral & gut microbiome functions & gene expression to discover early molecular signatures underlying onset & progression of a range of chronic diseases including IBD. When it comes to IBD, apart from gut microbiome functions/pathways, we measure & quantify oral microbial pathways which decodes movement towards or away from IBD. Some of these pathways include -Oral LPS Production -Oral TMAO Production -Nitric Oxide Production -Mucin Degradation pathways If you are experiencing bloating or constipation, think again! Mouthwash or inflammatory activities happening inside your mouth could be potential trigger https://lnkd.in/gbjQ8wdj We are leading preventative healthcare from the front by building, analyzing & interpreting India’s first molecular & genes expression data sets to discover pre-disease molecular signatures & eliminate them using precision nutrition therapeutics. More details here: www.genefitletics.com Citations https://lnkd.in/dx-MPASr https://lnkd.in/g8HE94-M https://lnkd.in/gAV5hEaw #IBD #bloating #constipation #oralhealth #leakygut #periodontaldisease Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak

Cancer is a metabolic disease & starts with mitochondrial dysfunction/damage of oxidative phosphorylation. The underlying signals of this metabolic dysfunction, which develops slowly over a period of a few years, are asymptomatic & cannot be measured by standard of care diagnostic investigations. By the time symptoms show up, the patient has already missed the bus. What comes next is standard hospital practice of series of radiation & chemotherapies aka attacking your cells with unwanted poison, with poor clinical outcomes & low survival rates In larger no of cases, these harmful chemicals destroy other healthy cells, triggering a collateral damage Still, none of healthcare practitioners & hospitals make concerted efforts to recommend & structure a precision nutrition program that could starve tumors/cancer cells ( obviously, they are never taught nutrition in their grad school). How can you blend nutrition with these chemicals when your oncologist is bent on encashing your misery? Two food substrates should be minimized or avoided when you are undergoing post cancer treatment/therapies -Glucose: Cancer cells are well versed about ancient fermentation pathways & ferment glucose that gives them substantial energy to proliferate & grow. As a byproduct of glucose fermentation, they release lactic acid, succinic acid that acidifies microenvironment, further damaging oxidative phosphorylation. Search Warburg effect & you will find about glucose fermentation -Glutamine- Cancer cells feed on glutamine. Although glutamine is a non essential amino acid, it plays a key role in various physiological processes including urea cycle & is essential metabolite for immune system & gut. There are numerous foods that have glutamine. Unfortunately, this food substrate helps cancer cells proliferate & foods having glutamine should be avoided. Certain hacks that could inhibit cancer cell growth include certain flavonoids such as EGCG  that inhibits glutamine production However, which specific foods should be part of your diet would depend on thousands of other biochemical functions. We measure all thousands of  functions preceding tumor development & construct a precision nutrition program that eliminates molecules involved in oral cancer onset. https://lnkd.in/g3sS7Q-A Citation https://lnkd.in/g7TPVZmg #cancer #oralcancer #cancerawareness #fermentation #type2diabetes #mitochondriadysfunction Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak Rupinder Singh

Over the last 4-5 years, we have seen a flurry of gut microbiome DNA testing companies, claiming they have an out of box solution to reverse most chronic diseases! I am afraid this is far away from reality! No doubt, Gut microbiome has a vital role to play in overall physiology but these companies have less than optimal approach on two fronts -These companies do not focus on the system biology approach & fail to study other areas of microbiome including oral, skin, vaginal, scalp, immune system, mitochondria, hormonal health, heavy metals, toxins & more. -Driven by their investor/VC funds philosophy, these companies have adopted primitive DNA sequencing tech to make it an FMCG product/service rather than focussing on bringing scientific breakthroughs. These companies focusses on microbial composition & potential & fail to measure the biochemical functions  at molecular level, thereby lacking precision ,efficacy & accuracy. A complete departure from this linear outdated model, we at Genefitletics have adopted a system biology approach to -Offer system biology + mathematics platform - Measure the biochemical functions of gut & oral microbiome -Measure mitochondrial functions - collect, process & analyze molecular, longitudinal & clinical data related to microbiome functions to predict onset of various diseases including type 2 diabetes, cardiovascular diseases, chronic kidney disease & halitosis  -Machine learnt models to predict glycemic response to 300 plus foods -Construct data driven precision nutrition & therapeutics interventions to rebalance an individuals’s biology -Collect longitudinal data at regular intervals to train our ML model, assess the efficacy of our interventions & revise the recommendations aligned with changes in individual’s biochemistry -now also offer oral cancer early detect test & associated disease prevention interventions https://lnkd.in/g3xmzgXB Access to platform is now available for a monthly subscription model starting at Rs.2,500( $ 31) a month More details here: www.genefitletics.com #microbiome #chronicdiseases #cancer Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak Rupinder Singh

We have all requisite science & tech in place to deeply understand the mechanism of onset & progression of chronic diseases & cancer & develop tech driven strategies to prevent these life threatening diseases , stop their progression or outrightly reverse them. We have to just change the way we implement science. We need to change our focus from symptoms based healthcare delivery data to molecular & genes expression data We need to overcome fragmentation of scientific efforts & drive our energy towards disseminating the scientific literary around human & microbial biochemistry To meet these nobel objectives, we have created a whatsapp group of healthcare professionals( not entrepreneurs), system biologists, biochemistry experts, doctors, oncologists, dentists to share &  spread science driven knowledge within the healthcare, biotech & patient community. The group’s primary objective will be to -Share scientific knowledge relevant to chronic diseases & cancer -Conduct a bi-monthly e-meet focused on framing & executing game plans for expanding our reach & deliberating on new scientific breakthroughs. -Webinar/podcasts on discussing preventative solutions for hard to detect diseases. The group is for serious folks & science related discussion only. Anyone promoting or upselling their products/services will be banned Let's educate together Here is the link to join : https://lnkd.in/gMKw_wJG #community #healthcare #biotech #deeptech #chronicdiseases #cancer

Do you think human genes are your destiny ?  If yes, welcome to basic primary school english class today! From A  to Z- there are 26 alphabets ( I am not going to list them 😀) , No brainer right! If all the 26 alphabets are listed in chronological order, can you make sense out of that ? NO However, these alphabets can be used to form words, sentences, paragraphs & write stories. Depending upon what Alphabets you select, you can write a thriller, comedy, action or romantic story. Our biochemistry story has a similar plot. Consider these alphabets as your genes while the story is how those genes are expressed. Your genes remain static like chronological order or alphabets Depending upon external triggers( nutrition,stress, environment etc), genes can either be underexpressed or overexpressed (DNA to RNA) which leads to activation of protein to perform/inhibit a particular biochemical function- be it such as digesting food, regulating your blood sugar level, killing pathogens , producing neurotransmitters & more. Similar to our thoughts ( external triggers) may drive us to write comedy, horror or thriller stories(gene expression). Even certain mutations(DNA /RNA damage) is due to external trigger( inflammation, ROS, oxidative stress) Just decoding which human genes are there or which microbes are present does not translate into functions & is complete whitewash. Focus on expression of genes & related protein expression( biochemical functions). https://lnkd.in/gtHANpj9 #DNA #chronicdiseases #inflammation #oxidativestress

Cancer has become a biggest epidemic with 2100 Indians losing their lives to this life threatening disease daily. While the government has put a lot of effort into building cancer care centers & a lot of private commercial hospitals have come up to treat cancer, the success rate is very low & a cause of concern. Overall, the 5 year survival rate of  cancer is less than 50%, a big reason to worry. Still we see a lot of misinformation as to the cause of cancer & we have seen a lot of genetic companies propagating that cancer is a genetic disease. I am afraid, this is far away from the truth. Cancer is a metabolic disease & is caused by mitochondrial dysfunction. There are multiple causes of mitochondria dysfunction(damaged oxidative phosphorylation) which includes chronic inflammation, oxidative stress, carcinogenic toxins, certain viruses & more. In simple words, cancer is dysregulated cell growth. Mitochondria regulates & controls cell cycle & when mitochondria becomes dysfunctional, it leads to unregulated growth of cancer cells( even normal cells can become cancerous). We all know mitochondria produces ATP through the process of oxidative phosphorylation using oxygen. In case of damaged oxidative phosphorylation, cancer cells use ancient fermentation pathways by fermenting two major fuels- glucose & glutamine.  As a result of this fermentation, waste products such as lactic acid & succinic acid are produced which causes acidification of the microenvironment which further damages oxidative phosphorylation. This has a spillover effect which leads to cancer cell growth & proliferation which later spreads across the body. It is this cancer cell/tumor growth that PET scan usually shows which forms basis for radiation & chemotherapy However, this does not stop there. When there is mitochondria dysfunction, mitochondria ceases to produce ATP, rather it produces ROS which damages protein, lipids, RNA & DNA. This is what most healthcare practitioners refer to as genetic mutation( such as P53 mutation). It is not out of place to mention that this is the downstream effect of underlying cause- mitochondrial dysfunction, not the cause itself. Our today’s discusses deep dives into how we develop cancer & how early detection of cancer & associated precision nutrition interventions can help prevent cancer & bring body back into homeostasis : https://lnkd.in/gNszjMgu Citations https://lnkd.in/g9KA9Zay https://lnkd.in/gqNzJehM https://lnkd.in/ggDXeknP #cancer #cancerawarness #oncology #oralcancer #mitochondriadysfunction Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak Rupinder Singh Tarun Kumar

Way back in 2013, #healthtech sector for the startup ecosystem was considered as a new category given the scope of e-commerce & marketplace businesses. This saw a number of startups being built on a market place model to list diagnostic tests, medicines & doctors to offer their services & make a marketplace commission out of it. In essence, these startups were not healthtech but marketplace models for reactive healthcare. The new love for VC saw a lot of money being poured into such marketplace models, which saw very miniscule profitable ventures shaping up. Not out of place to mention that these were models copied from the west. These were considered lucrative as at that time healthcare lacked knowledge ecosystem around molecular & cellular biology Most VC(s), investing in this space made money on revenue-multiple models. But this obsession for alpha returns made this revenue multiple a standard practice for valuing businesses, which saw a growth in funding dependent businesses & resulting in closure of a huge number of startups Coming back to healthtech, we again, since 2017-18, saw a new wave of wearables & these coaches led weight loss businesses. But, one thing changed during this time- incidence of chronic diseases increased while none of these businesses have solutions to prevent diseases, stop its progression or outrightly reverse them. There was a lot of enthusiasm initially with money being poured in genetic, CGM  & other wearable tech , supplement & those AI- prefix businesses( while there was nothing AI in them). However, over the last few years, we have seen these biz lack efficacy to bring any preventative solutions.These startups,are raising new rounds of funding(just to survive), giving their existing investors a fair returns, while not solving for the health of  consumers, the basis reason why these startups were floated. This period has seen a lot of overinflated valuation based on revenue multiple which I opine is not valuation but pricing an asset. Next 5 years, India would see a substantial growth in deep biotech startups giving the research around microbiome, molecular & cellular biology. VC funds are looking forward to encashing this but to make sure that the investments into this new age deep tech translate into a combined results of improved health outcome & alpha returns for funds, these funds should have the right set of subject matter experts onboard to correctly evaluate the potential of each startup. Funds should also re-look at their investment philosophy &  R & D & building huge data sets relevant to molecular & cellular health should find an important place in their fund deployment strategy. Sharing a piece of how we are disrupting this deep tech system biology space : https://lnkd.in/guSQWB3D #biotech #deeptech #healthcare #chronicdiseases Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak Rupinder Singh Tarun Kumar