Biological Sciences Group Journals

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https://lnkd.in/gWs8UBe3     Article title: Distinct genetic variants of early and late-onset prostate cancer   Author(S): Victor Chalfant#, Samuel Serrano#, Mohamed Al-Toubat*, Carlos Riveros#, Ahmed Elshafei and KC Balaji   Journal: Insights of Epigenetics and Chromatin Abstract: Background: The incidence of early-onset Prostate Cancer (PCa) has increased in the last two decades. Men diagnosed with PCa before age 55 have lower 5-year relative survival rates compared to patients diagnosed later in life. Given the enhanced lethality of early-onset PCa, our aim is to evaluate somatic differences between early and late-onset PCa. Methods: Patients with PCa were dichotomized into early (< 55 years old) and late-onset PCa (≥ 55 years old). Data is derived from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (GENIE) registry. The GENIE registry contains sequenced tumor samples and clinical data across many cancers a total of 4,546 Patients and 5,740 samples were included with pathologically confirmed prostate adenocarcinoma. The data is derived from 17 cancer centers from 2011 to 2021. Patterns in somatic gene tumor profiles were compared between early-onset and late-onset PCa using a chi-square test and logistic regression. #Earlyonsetprostatecancer #Genesequencing #ERF #CDK12 #Genetherapeutics   #DNAMethylation #HistoneModifications #ChromatinRemodeling #EpigeneticRegulation #EpigeneticInheritance #ChromatinStructure #HistoneAcetylation #GeneExpression #EpigeneticModification #ChromatinArchitecture #ChromatinDynamics #EpigeneticMarkers #NonCodingRNAs #ChromatinOrganization #ChromatinFunction #DNAAccessibility #EpigeneticMemory #TranscriptionalRegulation #EpigeneticTherapy #ChromatinInteractions

https://lnkd.in/gEaCqRmC   Article title: A sirtuin 6 activator in the pipeline: New perspectives in depressive disorder treatment   Author(S): Ana Carolina de Oliveira Pereira, Gabriel Almeida Mendonça da Silva, José C. Barros and Raoni Schroeder Borges Gonçalves*   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Major Depressive Disorder (MDD) is among the most prevalent mental illnesses worldwide. Its symptoms include persistent feelings of sadness, loss of interest in previously enjoyed activities, and a lack of motivation for daily tasks. While FDA-approved medications are available, they often come with side effects, especially those targeting monoamine neurotransmitters like SSRIs and SNRIs. Thus, there is a need for innovative medications with different mechanisms of action. Sp-624, a derivative of griseofulvin, is currently undergoing clinical trials for MDD treatment. It acts as a sirtuin 6 (SIRT6) activator, offering a novel approach to treating this disorder. This article discusses the biochemical aspects related to the mechanism of action of sp-624, provides a brief overview of related patents, and highlights ongoing clinical trials involving this substance. #Majordepressivedisorder #Sp624 #Griseofulvin #Sirtuin #Antidepressant #Clinicaltrials   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/g5khsvVk   Article title: Pillaging plucking plundering ransacking proteomes via CPLL technology   Author(S): Pier Giorgio Righetti* and Egisto Boschetti   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: No proteome can be considered “democratic”, but rather “oligarchic” since a few proteins dominate the landscape and often obliterate the signal of the rare ones. That is the reason why most scientists lament that, in proteome analysis, the same set of abundant proteins is repeatedly seen. Current pre-fractionation techniques, one way or another, are besieged by problems, in that they are based on a “depletion principle”, i.e. elimination of unwanted species. Yet “democracy” calls for giving “equal rights” to everyone. One way to achieve that would be the use of libraries of combinatorial ligands coupled to spherical beads. When these beads are contacted with complex proteomes (e.g., human urines and sera, egg white, any cell or tissue lysate) of widely differing protein composition and relative abundances, they are able to “normalize” the protein population, by sharply reducing the concentration of the most abundant components while simultaneously enhancing the level of the most dilute components. It is felt that this method could offer a strong step forward in bringing the “unseen proteome” (due to either low abundance and/or presence of interferences) within the detection capabilities of current proteomics detection methods. #Hiddenproteome #Combinatoriallibraries #Hexapeptidebaits #Urinaryproteins #Plasmaproteins   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/gQREpStx   Article title: Genetic variants of COVID-19 and vaccination. Is there a Correlation?   Author(S): Nagwa Ali Sabri*, Mohamed Ahmed Raslan, Eslam Mansour Shehata and Sara Ahmed Raslan   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Background: New coronavirus disease is considered one of the most widely spreading viral infections all over the world. Increased numbers of severe covid-19 cases are growing up. Gene sequencing and discovering new viral variants is an essential aspect during the pandemic. The generation of treatment-resistant viral strains and the probability of negative impact on vaccination efficacy is possible. We aimed to review the probable effect of new variant emergence on treatment and vaccination efficacy, besides, the importance of gene sequencing from published literature data till the moment. Main body of the abstract: SARS-CoV-2 genome studies indicated that it shared 79 to 82% nucleotide similarity with SARS-CoV-1. Several gene locations in the envelope (E) structural protein c.222G>C (p. Leu74Leu) and the Membrane (M) structural protein c.213C>T (p. Tyr71Tyr) were proved to have mutations. Also, the surface (S) gene mutation c.1841A>G (p. Asp614Gly) is most relevant. The published sequences in Egypt are accounting for less than 0.2 percent of reported instances. #COVID19 #Genesequencing #Mutation #Antiviralagents #Spikeglycoprotein   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/gAdhuiD7   Article title: COVID-19 and SARS-CoV-2: Despite the vaccination, new targets/drugs for treatment and the virus cycle mechanisms still have to be continually investigated   Author(S): Victor GO Evangelho, Camila F Mattos, Marcia R Amorim, Juliana S Novais, Marcos K Veiga, Murilo L Bello* and Helena C Castro*   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Several countries are suffering with COVID-19 second wave that has been worse than the first one. In addition, new challenges are being imposed by new mutations and their high transmissibility, such as B.1.1.7, identified in the United Kingdom, and the strains P.1 and 501Y.V2, from Brazil and South Africa, respectively. They threaten the immune effects of the new launched vaccines (eg.: Coronavax, Oxford vaccine, and Sputnik) as nobody can assure their effectiveness against all coronavirus mutants that are still ahead. Finally, vaccination of the whole population against coronavirus, as it is done for influenza in the elderly people, is financially very difficult, especially in the low-income countries. Therefore, this brief 2-page opinion comes to highlight the fact that, similar to HIV infection (AIDS), COVID-19 will need continuous research about the virus cycle mechanisms and drug design/searching for new antivirus that may treat those infected with this still unknown virus to avoid its major effects and high lethality worldwide.     #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/gu2YfH6J   Article title: In silico design of angiotensin-converting enzyme 2 (ACE2) recombinant protein to block the S1 protein pathway of COVID-19 virus   Author(S): Yaser Ghazi*   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Coronavirus is a large family of viruses that includes the common cold and the SARS virus. The Chinese corona, or coronavirus, is a new respiratory virus that began in late 2019 and early 2020 in the province of Hubby and Wuhan, China, and became known as COVID-19. The COVID-19 virus genome is a positive single-stranded RNA (ssRNA (+)) and is 29903 nucleotides long, encoding twelve different proteins. One of these proteins is called the S-protein. During the S-protein contamination cycle, it is divided into two subunits, S1 and S2. The subunit S1, which contains the Receptor Binding Protein (RBD), binds directly to the protease domain of the Angiotensin-Converting Enzyme 2 (ACE2) protein and enters the cell through it. In this study first the ACE2 protein sequence extracted from the NCBI site. To convert the protein to an extracellular protein and excrete it out of the cell, the signal peptide sequence was added to the beginning of the recombinant protein and two amino acids, cysteine and asparagine, added to both sides of the signal peptide sequence to create a self-catalyzing process similar to that found in Inteins. The identifiable motif was then incompletely added to both sides of the peptide signal sequence by ACE2 sequences with F-H-L amino acids sequence.   #Coronavirus #Sprotein #NCBIsite #ACE2protein #Intein   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/gEMhcPSs   Article title: Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review   Author(S): Xuena Li, Ying Han, Aihua Zhang, Jianhua Miao1, Hui Sun, Guangli Yan, Fangfang Wu and Xijun Wang*   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Colon cancer is a common gastrointestinal malignancy in daily life and is the third most common cancer. So far, the global incidence of colon cancer has risen every year. Colon cancer mortality accounts for half of the incidence, colon cancer mortality ranks fifth in malignant tumor mortality, which seriously threatens human survival and health. This article refers to the latest domestic and foreign related articles related to colon cancer. It summarizes common and emerging screening methods for colon cancer which can make early detection and early treatment of the disease for reducing the deterioration and metastasis of colon cancer. It discusses the diagnostic markers of colon cancer found out in recent years and its mechanism of action, to improve the level, accuracy and scientificity of diagnosis. This article points out that the metastasis of colon cancer is the main cause of death in patients with colon cancer and to discuss the mechanism of its metastasis. It also summarizes the therapy thereof and advantages and disadvantages of colon cancer from different aspects such as intestinal flora, targeted therapy, traditional Chinese medicine and western medicine. Finally, the article summaries some methods that can effectively prevent colon cancer, reduce the occurrence of colon cancer from the source and improve people’s quality of life.   #Coloncancer #Screening #Diagnosis #Metastasis #Therapy #Intestinalflora #Prevention   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/g9CvMKY5   Article title: Recent advances in understanding cross-talk between Bile Acids and Gut Microbiota   Author(S): Cheng-cheng Feng, Ai-hua Zhang, Jian-hua Miao, Hui Sun, Ying Han, Guang-li Yan, Fang-fang Wu and Xi-jun Wang*   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Bile acid (BA) plays an important role in the absorption and translocation of fat and fat-soluble vitamins. In addition, it can also act as a signaling molecule to influence the energy metabolism of organisms, glucose metabolism, and the development of liver and intestinal diseases by activating receptor. Gut microbiota participates in the metabolism and transport of BA, which changes the BA associated with the occurrence and development of a variety of diseases. This is achieved through a variety of regulatory processes and is intrinsically linked to host physiology. In recent years, many scholars have used 16S rRNA gene sequencing in conjunction with serum, urine, and fecal metabolomics methods to study the mechanisms underlying the occurrence and development of disease associated with BA and gut microbiota, or to evaluate the protective action of drugs on the metabolic phenotype in rats with gut microbiota disorder. On the one hand, the gut microbiota regulates BA by activating receptors such as FXR, TGR5, and FGF15, and can regulate BA synthesis through enzyme reaction. In addition, gut microbiota can effectively hydrolyze bound parasites or heterogenous organisms that have been cleared by BA. On the other hand, BA can alter the composition of the gut microbiota by inhibiting the growth of bacteria in the intestine. These studies provide new ideas for further elucidating the relationship between gut microbiota and BA and treatment for related disease.   #Bileacid #Gutmicrobiota #FXR #TGR5 #Receptors #Interaction   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics

https://lnkd.in/gV-3mTR2   Article title: Exploring the detoxification effects and mechanism of Caowu in prescription using liquid chromatography-high-resolution mass spectrometry-based metabolomics   Author(S): Li Wang, Hui Dong, Ai-hua Zhang, Ying Han, Tai-ping Li, Le Yang, Hui Sun, Xiang-cai Meng and Xi-jun Wang*   Journal: Open Journal of Proteomics and Genomics   Journal ISSN: 2692-4641 Abstract: Liquid chromatography/mass spectrometry-based metabolomics analyses have been used in the evaluation of drug toxicity and finding detoxification methods. Yunnan Baiyao (YNBY) is a famous prescription for its effects on traumatic blood stasis in China. However, the side effects of YNBY including anaphylactic shock, arrhythmia and renal failure hindered its further development due to Aconite kusnezoffii Radix. (caowu) in YNBY. The purpose of our research is to study the safety of YNBY compatibility of caowu for 4 weeks on SD rats by oral administration. In this study, we determined the toxic effects on rats by conducting examinations of histopathological and clinical physiological and biochemical indicators. Next, we prospectively analyzed known metabolites using an untargeted approach in serum of SD rats administrated with YNBY and NCY (caowu replaced by excipient from YNBY) respectively for four weeks by mass spectrometry analysis. As a result, we found caowu in YNBY had no toxicity on rats according to general toxicological evaluations. It was no obvious difference between administration and control groups on AKP, GOT, GPT, BUN, CK, MDA and LDH, except Na+/K+-ATPase (ATP) and SOD index. NCY had a greater influence on rats than YNBY according to metabolism. In this study, we found 77 biomarkers in YNBY and 110 biomarker of NCY, involved 12 and 20 metabolic pathways respectively.   #Liquidchromatography #Massspectrometry #Metabolomics #Aconitekusnezoffiiradix #Detoxification #Prescription   #ProteomeResearch #ProteomicsBioinformatics #MolecularCellularProteomics #ProteomicsInsights #OrganellesProteomics #ClinicalProteomics #ProteinsProteomics #HumanProteome #Peertechz #PeertechzPublications #ProteomeScience #CancerStemCellProteomics #FungalProteomics #AlgalProteomics #BacterialProteomics #RecombinantProteomics #PlantProteomics #GeneTherapy #GenomeBiology #GenomicsResearch #Pharmacogenomics #StructuralGenomics #Epigenomics #ComputationalGenomics #Metagenomics #FunctionalGenomics