AboutScience

Congenital thrombotic thrombocytopenic purpura (#cTTP) is a rare #geneticdisorder causing significant health, economic, and social impacts. A study in Italy analyzed these effects on 15 patients through a questionnaire covering direct medical and indirect costs, including productivity loss. Findings showed that quality-of-life issues and productivity losses were the largest burdens. This emphasizes the need for a multidisciplinary approach to cTTP management, along with comprehensive support networks to address the broader impacts on patients and society. | https://ow.ly/3MpC50TUsYn

This study evaluated the #cytotoxicity, #selectivity, and #clonogenicity of fruits and resins from Saudi medicinal plants against liver #cancer cells (HepG2). Opuntia ficus-indica (BEP-10) showed the most potent effect, with an IC50 of 2.82, comparable to doxorubicin. It also demonstrated a selective impact on cancer cells over normal cells. GC-MS analysis revealed key phytoconstituents, including furan derivatives. The study concludes that Opuntia ficus-indica has potential as an #anticancer agent, particularly against liver cancer cells. | https://ow.ly/kY4o50TQK6s

🌍 🌱 GCND is a promoter, through the "GCND for the Planet" section, of initiatives aimed at raising awareness among the medical class, nephrologists, nurses, technicians and companies, promoting sustainable solutions for both the health of patients and the planet. Discover the latest publications about #GreenNephrology ➡️https://ow.ly/mEkH50TNwWq #Sustainability #Nephrology #SustainableHealthcare #KidneyCare Società Italiana Nefrologia

🔬 September Highlight! 🔬 This paper by Bini et al. was the most viewed on #GRHTA in September! 📈✨ If you haven’t had a chance to read it yet, you can check it out here https://ow.ly/YANM50TILap

This study evaluated the persistence, adherence, and outcomes of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) for #psoriaticarthritis (PsA) in Italy, focusing on biosimilars. Conducted in eight hospitals from 2017 to 2020, it compared adalimumab and etanercept originators with their biosimilars. Findings revealed that 48.6% of patients remained persistent for one year, with similar adherence for adalimumab treatments but better outcomes for the etanercept biosimilar. The results support the use of #biosimilars to improve efficiency and optimize #healthcare resources.| https://ow.ly/wl8r50TIzS3

This study assessed the intra- and inter-rater reliability of goniometric finger #rangeofmotion (ROM) in healthy adults using a written protocol. Twenty participants were evaluated by three experienced occupational therapists. Results showed moderate to good intra-rater reliability (88.7%) but lower inter-rater reliability (69.0%), with no significant differences based on hand dominance, movement type, or joint. The use of a standardized protocol improved consistency, but physical differences between raters and participants may have affected inter-rater reliability. | https://ow.ly/42na50TGMHk

This study examined the effects of #levofloxacin on #erythrocytes, finding that therapeutic doses (7, 14 μM) led to oxidative stress, reduced antioxidant enzyme activity, cell shrinkage, phosphatidylserine externalization, and hemolysis. #Calcium was found to trigger erythrocyte shrinkage. The research highlights levofloxacin’s potential to induce #eryptosis (erythrocyte death) and #hemolysis, suggesting the need for cautious use of this antibiotic and further studies to address these side effects. | https://ow.ly/v0wB50TFyY4

This study evaluated Epic Sciences' circulating tumor cell (CTC)-based ERBB2 (#HER2) assay, designed to detect HER2 amplification in metastatic #breastcancer (MBC) patients using single-cell genomics. The assay showed 85% sensitivity and 94% specificity in detecting 2-fold ERBB2 amplification. In a clinical concordance study comparing CTC results with tissue biopsy, the assay had 69% sensitivity and 78% specificity for chromosomally unstable CTCs. The test is valuable for patients where tissue biopsy is unavailable or impractical. | https://ow.ly/wLs350TE85v

For over 13 years, the Italian Journal of Physiotherapy has evolved into a beacon for the #physiotherapy community, championing the importance of evidence-based practice. From humble beginnings in collaboration with Minerva Medica to its transformation into the internationally recognized Archives of Physiotherapy with #BioMedCentral, the journal has consistently upheld scientific rigor. Now partnered with #AboutScience, it embraces an #openaccess model, continuing to make impactful contributions to physiotherapy research and clinical practice. | https://ow.ly/ZR9150TC7aT

This study explores the potential of using Artificial Intelligence (#AI ), specifically Large Language Models like #ChatGPT, to aid in the #regulatoryprocesses for CE marking of #medicaldevices under EU Regulation 2017/745. It highlights how AI can support compliance, emphasizing the importance of prompt engineering to enhance AI output quality. The study also underscores the need for education and training to effectively integrate AI into regulatory workflows, improving performance and reliability in medical device market placement. | https://ow.ly/GAo650TAag9