Journal of Experimental & Clinical Cancer Research

New!🌏 SEC14L3 knockdown inhibited clear cell #renalcellcarcinoma proliferation, metastasis and #sunitinibresistance through an SEC14L3/RPS3/NFκB positive feedback loop ----------- Clear cell renal cell carcinoma (ccRCC) arises from the renal parenchymal epithelium and is the predominant malignant entity of renal cancer, exhibiting increasing incidence and mortality rates over time. SEC14-like 3 (SEC14L3) has emerged as a compelling target for cancer intervention; nevertheless, the precise clinical implications and molecular underpinnings of SEC14L3 in ccRCC remain elusive. This study by Peng et al. revealed upregulated SEC14L3 expression in ccRCC tissues, and exogenous downregulation of SEC14L3 robustly suppressed the malignant traits of ccRCC cells. Read more here 🔐 https://lnkd.in/dP_-5RC6 #Nanoparticles #TumorSuppressor

Just Pubished!🧁 Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer #immunotherapy in #neuroblastoma ------------- Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low neoantigen burden, such as neuroblastoma (NB). Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that trims peptides before loading on MHC class I molecules. Inhibition of ERAP1 results in the generation of new antigens able of inducing potent anti-tumor immune responses. Here, Doriana Fruci, Patrizia Tempora et al. identify a novel non-toxic combinatorial strategy based on genetic inhibition of ERAP1 and administration of the HDAC inhibitor (HDACi) entinostat that increase the immunogenicity of NB, making it responsive to PD-1 therapy. Open access🔓 https://lnkd.in/dp4A4ynN #Epigenetic #Combinationtherapy #Immunopeptidome

Online now!🍕 MCPIP1 modulates the #miRNA‒mRNA landscape in #keratinocytecarcinomas ------------ Monocyte Chemotactic Protein 1-Induced Protein 1 (MCPIP1, also called Regnase-1) is a negative modulator of inflammation with tumor-suppressive properties. Mice with keratinocyte-specific deletion of the Zc3h12a gene, encoding MCPIP1, (Mcpip1eKO mice) are more susceptible to the development of epidermal papillomas initiated by 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted by 2-O-tetradecanoylphorbol-13-acetate (TPA). The aim of this study by Jolanta Jura et al. was to investigate the MCPIP1 RNase-dependent microRNA (miRNA)‒mRNA regulatory network in chemically induced squamous cell carcinoma (SCC)-like skin papillomas. Look here👇 https://lnkd.in/d4bhY8Jb #Skincancer #Transcriptomics IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano

New Commentary 📝 Noval insights and therapeutic strategies for tumor-induced kidney pathologies ----- Enjoy! https://lnkd.in/dWmNg_N2 #Kidneypathology #Renaldysfunction IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano

Latest issue online!📲 Targeting #cancerassociatedfibroblasts/tumor cells cross-talk inhibits intrahepatic #cholangiocarcinoma progression via cell-cycle arrest ------------------- Cancer-associated fibroblasts (CAFs), mainly responsible for the desmoplastic reaction hallmark of intrahepatic Cholangiocarcinoma (iCCA), likely have a role in tumor aggressiveness and resistance to therapy, although the molecular mechanisms involved are unknown. Aim of this study by Gianluigi Giannelli, Serena Mancarella et al. is to investigate how targeting hCAF/iCCA cross-talk with a Notch1 inhibitor, namely Crenigacestat, may affect cancer progression. Look here👇 https://lnkd.in/d7E9z8T2 #Tumormicroenvironment #Livercancer IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano

Read this paper on JECCR ⏬ https://lnkd.in/dtYSjD9f Exosomal miR-106a-5p from highly metastatic #colorectalcancer cells drives liver metastasis by inducing #macrophage #M2polarization in the #tumormicroenvironment #Livermetastasis #Exosomes #miRNAs IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano

New study!⭐️ Hepatocyte-derived Igκ promotes HCC progression by stabilizing electron transfer flavoprotein subunit α to facilitate fatty acid β-oxidation ----------------------- Lipid metabolism dysregulation is a key characteristic of hepatocellular carcinoma (HCC) onset and progression. Elevated expression of immunoglobulin (Ig), especially the Igκ free light chain with a unique Vκ4-1/Jκ3 rearrangement in cancer cells, is linked to increased malignancy and has been implicated in colon cancer tumorigenesis. The aim of this study by Qiu et al was to elucidate the pivotal roles of hepatocyte-derived Igκ in HCC development. Open access🆓 https://lnkd.in/dGtHiQtp #Lipidmetabolism #Hepatocellularcarcinoma #Immunoglobulin #Carcinogenesis #Fattyacid IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano

New!🍹 Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors ---------- Despite significant progress in the prognosis of pediatric T-cell acute lymphoblastic leukemia (T-ALL) in recent decades, a notable portion of children still confronts challenges such as treatment resistance and recurrence, leading to limited options and a poor prognosis. LIM domain-binding protein 1 (LDB1) has been confirmed to exert a crucial role in various physiological and pathological processes. In this research, Hu et al aim to elucidate the underlying function and mechanisms of LDB1 within the background of T-ALL. Look here👇 https://lnkd.in/dwpxse27 #Leukemia #Transcriptionfactor IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano