React4life

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Innovating Women’s Health: A New Era for Hydration Studies Women’s health is gaining increasing attention, with a growing demand for effective, science-backed solutions for menopause-related challenges like vaginal and skin dryness, irritation, and loss of elasticity. As research advances, #OrganOnAchip technology is emerging as a powerful tool to develop predictive, human-relevant models for testing innovative treatments. At React4life, we have developed a Hydration Assay using #MIVO technology, designed to assess hydration, barrier function, and the effects of bioactive compounds on models mimicking skin and vaginal ageing. This approach could pave the way for more targeted, non-hormonal treatments to improve women’s well-being. Would you be interested in exploring this new application with us? 💡💜 #OrganOnChip #WomensHealth #Menopause #Innovation

From 2D to real 3D: A Game Changer in Translational Research Unlike traditional lab-on-chip systems, MIVO® technology truly supports 3D cultures, making it a breakthrough technology for histology and omics—essential tools at the forefront of tissue complexity and drug response analysis. With the ability to host spheroids, organoids, and biopsies, #MIVO faithfully replicates the in vivo environment, preserving tissue architecture and cell behavior in 3D. This is key for obtaining highly predictive and reliable data. 🚀 Why does this matter? ✅ Enables genomics, proteomics, and metabolomics studies for a deeper understanding of biological pathways and disease mechanisms. ✅ Supports histological analyses, allowing direct comparison with in vivo data—where histology remains the gold standard. ✅ Enables therapy Response analysis, helping to understand how treatments interact with tissue in a biologically relevant setting ✅ Unlocks personalized medicine by integrating patient-derived biopsies into translational research. MIVO® is paving the way for more accurate drug development and precision medicine. Are you ready to embrace the future of 3D research?

We’re thrilled to share that our Chief Scientist, Silvia Scaglione, will be a plenary speaker at the TermisEU2025 Conference, taking place in May in Freiburg, Germany. TERMIS is the leading European and global event in tissue engineering and regenerative medicine, bringing together researchers, clinicians, and industry experts to showcase cutting-edge advancements, challenges, and breakthroughs in the field. Join her for Plenary Lecture 3 on Friday, May 23, 2025, to explore the latest research on 3D tissue models and organ on chip technologies and their impact on disease modeling, regenerative medicine, and drug testing. Learn more 👉 https://lnkd.in/dR2KXC4f

Gut dysbiosis plays a key role in skin health, affecting multiple physiological processes With our MIVO-based Skin on Chip, we can accurately recreate the gut-skin axis in the lab, offering an advanced platform to study how nutraceuticals, probiotics, and functional ingredients impact skin health—from within.   ✨ How does it work? ✔️ Simulating oral absorption – We introduce a nutraceutical, probiotic, or active ingredient into the gut-on-chip model, where it interacts with the intestinal barrier, just like in the human body. ✔️ Systemic bioavailability – We analyze how these compounds interact with the intestinal barrier and reach the skin-on-chip model, mimicking the natural transport of bioavailable molecules. ✔️ Skin response – We can investigate a wide range of effects and mechanisms of action—whether it's hydration, anti-aging properties, barrier integrity, inflammation modulation, or any other specific outcome needed.   Looking for a more advanced way to study how ingested ingredients affect skin health?🔬 More predictive, more reliable, and closer to real human physiology. Let’s talk! 🚀 #beautyfromwithin

Skin Hydration Assay with #MIVO Organ-on-Chip Technology Looking for more accurate and predictive simulation of the hydration process? Our Skin on chip enables precise evaluation of treatments aimed at restoring optimal skin hydration levels, investigating not only the effectiveness of formulations but also their mechanism of action in a controlled and physiologically relevant environment. ***Key Features*** 👉 Realistic 3D tissue models to replicate true skin structure and function 📊 Precise measurements of hydration and elasticity 🧪 Support for multiple-dose evaluation of testing compounds 🔬 Mechanism of action analysis to understand how compounds influence hydration pathways at the cellular and molecular levels This advanced approach allows the recreation of various stages of skin aging, replicating the unique characteristics of each stage for more accurate and relevant testing. Learn more 👉 https://lnkd.in/dQFPymjR

🚀 Exciting News! Our latest publication in Engineered Regeneration showcases the power of #MIVO millifluidic technology in advancing cancer research! 🔬 Oral Mucositis-on-Chip Model → This cutting-edge in vitro model replicates oral mucositis, a common and challenging side effect of chemotherapy. 🦠 Key Findings: ✔️ Co-culture of multi-layered oral epithelial tissue with Fusobacterium nucleatum, a bacterium linked to oral mucositis. ✔️ Enables human disease modeling and cancer progression studies. ✔️ Provides a reliable platform for testing new therapeutic strategies. 💡 This breakthrough represents a major step toward more predictive in vitro models for oral wound healing and re-epithelialization, offering new hope for improved cancer treatments. 🔗 Read the full paper here: https://lnkd.in/d8qYx246

A recent study by Manful et al. discusses the limitations of the Franz diffusion cell for dermatological absorption studies, particularly the metabolism of test molecules by skin tissue, which can affect absorption data. To overcome this challenge, our MIVO®-based Skin on Chip platform enables dynamic flow conditions, improving the physiological relevance of transdermal absorption studies. The study highlights that MIVO provides a transdermal absorption rate comparable to the Franz cell, while offering a more controlled and physiologically relevant environment. These findings underscore the increasing need for advanced systems in dermatological research to enhance the predictive power of in vitro models. Learn more 👉 https://lnkd.in/dv5CA4dj

🚀 Join us for our next webinar on Skin-on-Chip technology! 🔬 In this session, we will explore how our MIVO-based Skin on Chip platform offers a more predictive and physiologically relevant alternative for testing dermocosmetic and pharmacological applications. We will discuss key experimental approaches, validation data, and scientific insights that demonstrate its advantages over traditional in vitro and in vivo models. 🗓 Date: February 25, 2025 ⏰ Time: 03:00 PM (CET) 📍 Register here: https://lnkd.in/dQi4q-Xg Don’t miss this opportunity to gain insights into advanced in vitro skin models and their impact on translational research and product development.

We're just back from Stockholm for the official kickoff of the #COMBAT project, an EU-funded initiative tackling dengue virus research and antiviral development. By replicating host-pathogen interactions, our #MIVO platform will be used to develop advanced in vitro models that investigate how the dengue virus interacts with the human immune system. This approach provides deeper insights into the progression of severe dengue symptoms, including high fever, bleeding, and organ failure, by analyzing the role of immune cells and cytokine storms, key drivers of severe cases. Exciting work to be done ahead—stay tuned for updates!