Sibylla Biotech

Ready for a second superbusy day at #BioEuropeSpring2025! Networking is amazing this year, and we enjoy being local as much as bringing forward new and old discussions to the next level. Although we don’t have free slots anymore, our CEO Lidia Pieri, our CTO Giovanni Spagnolli and our corporate development manager Lorenzo Alibrandi will be happy to catch up around a coffee machine or at the ice cream spot! #foldthefuture

⏳ Next week, from 17 to 19 March, we will be at BioEurope km0! Welcome to Milan! We have an outstanding tight agenda and are ready to push our story forward! #foldthefuture #sibylla Lidia Pieri Giovanni Spagnolli Lorenzo Alibrandi

🚀 At Sibylla Biotech, we are happy to share that we have disclosed our first results in the field of quantum computing. This technology holds the potential to revolutionize the future of drug discovery. 👉 What’s the challenge? De novo design of binders has the potential to accelerate drug discovery significantly. While existing AI-based methods have shown great promise, they often struggle to generate truly novel binders because they rely on training data. 💡 Our solution: We’ve developed a physics-based de novo design approach for hit discovery that doesn’t depend on training data. Our quantum algorithm simultaneously explores configuration and conformational space—an area where quantum computing excels due to its ability to navigate complex energy landscapes efficiently. ⚡ The results: Our approach has demonstrated a strong correlation with experimental data, even on current, early-stage quantum hardware, when applied to peptide binder design. This is just the beginning, and as quantum technology advances, we expect this study to be the seed for technological advancements that will impact the acceleration of drug discovery. We’re proud of this milestone and look forward to continuing our journey into this exciting intersection of physics, biology, and quantum computing! The job has been done in collaboration with our co-founder, Pietro Faccioli. #QuantumComputing #Sibylla #foldthefuture

🚀 BioEurope is just around the corner, and this year, it’s extra special for Sibylla—because it’s happening in our own backyard!🌟 We’re happy to open our doors and invite you to experience the space where our innovation comes to life. On the last day of the conference, join us at OpenZone for this exclusive opportunity to walk alongside us and our colleagues from Axxam, AGC Biologics and Champions Oncology, Inc. where the magic happens! 📅 Reserve your spot now and be part of this unique experience. We can’t wait to welcome you to our home! 🏡💡 #BioEurope #foldthefuture #OpenZone #Sibylla

Sibylla is looking for a motivated and passionate manager to lead the translational activities of our pioneering company. Why Join Us? 💡 Cutting-edge technology: Be part of a team pushing the boundaries of innovation. 😄 Amazing colleagues: Collaborate with talented and dedicated professionals. 🚀 Exciting growth opportunities: Help shape our journey as we build the company and advance towards clinical success. If you’re ready to make an impact and contribute to groundbreaking advancements, we’d love to hear from you! Become part of Sibylla and help us shape the future of medicine! #foldthefuture Please share!

🌍 Sibylla is today represented by our CEO Lidia Pieri at the AI Action Summit in Paris! As we navigate this transformative era, we are reminded of the collective responsibility to embrace this massive change by skilling, reskilling and upskilling stakeholders. Everybody on the global AI platform must focus on using this tool to amplify human potential while navigating the civilizational consequences of this technology with care and foresight. Good governance is critical. Let’s leave behind sensationalism and embrace a scientific method and pragmatic mindset, investing in a healthy, collaborative AI ecosystem where every stakeholder has a role in shaping the future. The future of AI requires multidisciplinary and multistakeholders exploration, to ensure AI not only transforms industries but also aligns with our shared values and societal goals. We are excited to continue these conversations and take action as individuals and as a company committed to developing and using AI to improve patients’ life. #AIActionSummit #foldthefuture #Sibylla

Our CEO, Lidia Pieri, has been elected Director of the Italian Tech Alliance, representing Italian founders and entrepreneurs. We welcome this news and share the commitment to creating a critical mass to foster Italian innovation globally! #foldthefuture together: investors, entrepreneurs, future leaders

🇮🇹✨ Italy has already established itself as a center of excellence in the Life Sciences sector—now is the time to embrace the ambition needed to shine on the global stage. Last night, we were proud and excited to present Sibylla Biotech's journey at the 8th "Italy on the Move" event alongside the 43rd J.P. Morgan Healthcare Conference in San Francisco. At Sibylla, we are inspired by the strength of Italy’s academic heritage, which nurtures an environment where visionary scientists can break boundaries and drive groundbreaking innovation. Our mission is to transform this innovative spirit into concrete solutions that improve patients' and families' lives. In our brief journey so far, we have witnessed a growing awareness of the importance of tech transfer and the increasing alignment of public and private initiatives to address the needs of biotech innovation. The expansion of the Italian VC ecosystem dedicated to biotech is a critical boost for Italy's excellence in achieving international recognition. This momentum empowers startups like ours to execute and create value and also amplifies the global impact of Italy's Life Sciences sector. This spirit of an indeed "Italy on the Move" could be felt tonight at Innovit, an extraordinary cultural hub to propel Italian innovation into the U.S. market. In this snapshot, we find ourselves alongside giants: Pierluigi Paracchi, CEO of Genenta, the only Italian biotech company listed on Nasdaq, and Alberto Acito, Innovit's Managing Director and driving force. It was just so cool to be there! We were deeply inspired by the words of Mauro Battocchi, Director General for the Promotion of the Italy System at the Italian Ministry of Foreign Affairs and International Cooperation, and Sergio Strozzi, Consul General of Italy in San Francisco, and by the many contacts allowed by the networking aperitif. We felt grateful and engaged to be part of this growing ecosystem where challenges become opportunities, and a profound commitment to human impact fuels innovation. More than ever, we are committed to doing our part to make it happen! Let’s show the world the full potential of Italian Life Sciences! 🌍✨ Lidia Pieri Giovanni Spagnolli #sibylla #foldthefuture

First Day at JPM Week: Inspiring, Marathon-like and Unforgettable. The first day of JPM Week has left us completely drained—but in the best possible way. Under a sincere, striking blue sky, the streets are alive with energy, buzzing with colleagues, familiar faces, and remarkable individuals we deeply admire—people who, day after day, are building the path of research and innovation to improve our present and shape the future for the next generation. The entire world of pharma and innovation is here, navigating the steep, gravity-defying streets of this incredible city (seriously, how do parked cars not roll away?). Every hotel and café downtown transforms into a meeting hub, a place where today’s milestones are celebrated and tomorrow’s visions are shared. For a small biotech like us, it’s an exhilarating and humbling experience. We walk up and down these impossible streets all day, meeting the big players in pharma and immersing ourselves in the incredible carousel of life that is JPM Week. It’s both exciting and exhausting. You collapse into bed at 8 PM, knowing the jet lag will wake you at 2 AM—but you’re already excited for tomorrow. More miles to walk, more connections to make, and another chance to play a small but meaningful role in this extraordinary ecosystem. Here’s to the journey, the people, and the vision that make it all worth it. Lidia Pieri Giovanni Spagnolli #JPMSF #sibylla #foldthefuture

🌟 Kicking off 2025! 🌟 We are excited to announce our participation in JPM Week 2025, the world’s premier healthcare and biotech event. This week offers a unique opportunity to connect with industry leaders, innovators, and investors shaping healthcare's future. At Sibylla, we are dedicated to addressing unmet medical needs through revolutionary innovations. As the pioneers of protein folding interference therapeutics, we’re transforming the drug discovery landscape. During JPM Week, our CEO Lidia Pieri and CTO Giovanni Spagnolli will be sharing key insights, exploring strategic partnerships, and showcasing how our unique approach is driving impactful change in the industry. 📅 When: January 12 to 17 📍 Where: San Francisco, in person If you’re attending JPM Week and would like to connect, feel free to reach out! Let’s explore opportunities to collaborate and hashtag #foldthefuture together. Ready for an inspiring and transformative week ahead! 🚀 #JPMWeek2025 #Sibylla