Post di SIM - Società Italiana di Microbiologia

“The microbiota is inherited from the mother at birth” Most of the expansion in gut microbiota diversity occurs after birth, during the first few years of life, and increases most dramatically after weaning. Every adult ends up with a unique microbiota configuration, even identical twins that are raised in the same household. Therefore, although microbiota assembly is not yet fully understood, adult microbial communities seem to be predominantly shaped by prior stochastic environmental exposures, as well as multiple other factors such as diet, antibiotic therapy and host genetics, with direct ‘inheritance’ from the mother at birth playing a similarly lesser role.

Postbiotics a powerfull ally in the treatment of leaky gut syndrome. In this article published on Agro Food Industry Hi-tech issue 1/2024 you can discover how postbiotics can help in leaky gut syndorme, protecting gut barriers and modulating immune response https://lnkd.in/dCCptQ-5 Thanks to our R&D team for writing this review. #agrofoodindustryhitech  #postbiotica #postbiotics #microbiota #leakygut tks | publisher, event organiser, media agency

I have been receiving several requests to share this figure I presented at the ESPEN - European Society for Clinical Nutrition and Metabolism meeting in Milan earlier this year, which highlights the importance of early and continuous nutrition intervention for patients with cancer. Please feel free to use it as a resource for your educational materials. This is a similar analogy to what we used in our wildfire paper: https://lnkd.in/g7RCvnnq The journey through cancer and treatment is like embarking on a long road trip. Early intervention is comparable to starting with a full tank of gas and a well-maintained car. When you begin with proper nutrition, your body is better prepared to handle the challenges ahead, minimizing the risk of muscle loss slowing you down. Continuing intervention, on the other hand, is like making regular stops to refuel, check the tires, and ensure the car remains in good condition. Just as you would not drive cross-country without necessary pit stops, your body requires ongoing nutritional support to maintain strength and prevent breakdowns, keeping you on track toward recovery.

🌟 𝐁𝐢𝐨𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐢𝐥𝐢𝐭𝐲 ≠ 𝐁𝐢𝐨𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲: 𝐃𝐞𝐛𝐮𝐧𝐤𝐢𝐧𝐠 𝐭𝐡𝐞 𝐂𝐨𝐥𝐥𝐚𝐠𝐞𝐧 𝐏𝐞𝐩𝐭𝐢𝐝𝐞 𝐌𝐲𝐭𝐡 🌟   After a quick consultation with Merriam-Webster... 𝐁𝐢𝐨𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐢𝐥𝐢𝐭𝐲: The rate and degree a substance is absorbed and made available. 𝐁𝐢𝐨𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲: The ability of a substance to have an effect on a living organism — to be active.   ⚡ 𝐖𝐡𝐚𝐭 𝐝𝐨𝐞𝐬 𝐭𝐡𝐢𝐬 𝐦𝐞𝐚𝐧 𝐟𝐨𝐫 𝐜𝐨𝐥𝐥𝐚𝐠𝐞𝐧 𝐩𝐞𝐩𝐭𝐢𝐝𝐞𝐬? ⚡   All collagen peptides, derived from animal sources (bovine, porcine, fish, poultry), are highly digestible (~99%) and bioavailable. They fuel the cells as individual amino acids and di- or tri-peptides. But here’s the key: Not all collagen peptides are bioactive. 🧬   𝐁𝐢𝐨𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐟𝐮𝐞𝐥𝐬 𝐲𝐨𝐮𝐫 𝐜𝐞𝐥𝐥𝐬. 𝐁𝐢𝐨𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐭𝐮𝐧𝐞𝐬 𝐭𝐡𝐞 𝐞𝐧𝐠𝐢𝐧𝐞, 𝐬𝐭𝐢𝐦𝐮𝐥𝐚𝐭𝐢𝐧𝐠 𝐟𝐢𝐛𝐫𝐨𝐛𝐥𝐚𝐬𝐭𝐬 𝐭𝐨 𝐩𝐫𝐨𝐝𝐮𝐜𝐞 𝐦𝐨𝐫𝐞 𝐜𝐨𝐥𝐥𝐚𝐠𝐞𝐧.   While amino acid compositions may slightly vary between sources, the collagen type and raw material source do NOT determine bioactivity or cell stimulation.   ✔️ More than 28 types of collagen exist, but during hydrolysis, collagen types are undone and indistinguishable. The myth that collagen type impacts efficacy? Busted. 💥   𝐍𝐨𝐭 𝐚𝐥𝐥 𝐜𝐨𝐥𝐥𝐚𝐠𝐞𝐧 𝐩𝐞𝐩𝐭𝐢𝐝𝐞𝐬 𝐚𝐫𝐞 𝐜𝐫𝐞𝐚𝐭𝐞𝐝 𝐞𝐪𝐮𝐚𝐥 — 𝐢𝐭’𝐬 𝐛𝐢𝐨𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐭𝐡𝐚𝐭 𝐦𝐚𝐤𝐞𝐬 𝐭𝐡𝐞 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐜𝐞! 𝐦𝐨𝐫𝐞 𝐜𝐨𝐥𝐥𝐚𝐠𝐞𝐧. Curious to find out more about bioactive collagen peptides (BCP®)? Make sure to check out our website today and get in touch with our team of experts! 👉 https://lnkd.in/erKhVrhC   #CollagenPeptides #HealthScience #GELITA #VERISOL

👉#mdpinutraceuticals Recommended Reading: #Vitamin D Physiology, Deficiency, Genetic Influence, and the Effects of Daily vs. Bolus Doses of Vitamin D on Overall Health: A Clinical Approach, by Vincenzo Sorrenti 🔗https://lnkd.in/ggceCJ54 #nutraceuticals #openaccess #mdpi

Gut Age Index: A New Predictor of Microbiome Aging? #Mysummary The study introduces the Gut Age Index (GAI), a machine-learning model based on gut microbiome data to assess health and predict chronic diseases. The study used16S rRNA sequencing data from the Guangdong Gut Microbiome Project (GGMP) and the American Gut Project (AGP), covering over 12,000 participants. The study showed that: 🔹Healthy individuals had higher diversity and stability in gut microbiota...nothing we didn't know! 🔹Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bacteroides were enriched in healthy individuals, while Escherichia coli and Enterococcus faecium were more abundant in non-healthy individuals...same as above! What was new is that GAI outperformed existing indices, such as the Gut Microbiome Health Index (GMHI) and Shannon diversity, in distinguishing health statuses. i.e. GAI was over 70% accurate in predicting atherosclerosis and diabetes. #Mythoughts I find gut microbiome predictors that rely solely on bacterial profiles to assess health status, including this model, insufficient for clinical application in the near future. A critical limitation is their failure to integrate essential lifestyle factors such as diet, environment, and other behavioral data, which are pivotal in shaping the microbiome and influencing health outcomes. HAPPY to hear your THOUGHTS and stay POSITIVE! #Myinspiration “We all need people who will give us feedback. That's how we improve.” Bill Gates Link to the paper here: https://lnkd.in/ehmrpjaZ #microbiome #science #biology #health #pharma #diet #nutrition #probiotics #therapeutics #startup #biotech

Short Chain Fatty Acids: It may not be that simple Over the last decade, metagenomics has expanded our understanding of bacteria’s role in health but new research shows that caution, method and patience in interpretation are key as even butyrate and propionate, accepted as gut health champions, can act as danger signals under certain conditions. In this study "Butyrate and Propionate Are Microbial Danger Signals That Activate the NLRP3 Inflammasome," (https://lnkd.in/ef8dQ738) researchers reveal how these shortchain fatty acids (SCFAs) can trigger inflammation in human macrophages when Tolllike receptors (TLRs) are activated. ·     SCFAs like butyrate and propionate, typically anti-inflammatory, can activate the NLRP3 inflammasome and drive proinflammatory responses. ·     This discovery challenges their traditional role in gut health and highlights them as potential danger signals during inflammation. ·     The findings could lead to new treatment approaches for diseases like inflammatory bowel disease (IBD), where controlling inflammation is crucial. #Microbiome #Inflammation #Butyrate #Propionate #PersonalizedMedicine

💥🔬 Great News: the new article by Maria Magdalena Coman, nadaniela egidi, Stefania Silvi, Renato De Leone and MARIA CRISTINA VERDENELLI "Probiotic SYNBIO® Blend’s Impact on Constipation in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" is out now. Chronic constipation, often linked to gut microbiota imbalance, affects millions worldwide, limiting quality of life and remaining challenging to manage with traditional therapies. ✨ This is why probiotics are increasingly researched: the SYNBIO® blend by Synbiotec Srl and University of Camerino, featuring Lacticaseibacillus rhamnosus IMC 501® (DSM 16104) and Lacticaseibacillus paracasei IMC 502® (DSM 16105), has shown promising benefits for supporting regularity, alleviating symptoms, and enhancing overall well-being. Ongoing studies are exploring its impact on stool output and quality of life. 👉 Read more here: https://lnkd.in/er4kBPTR #SaccoSystem #GutHealth #Probiotics #SYNBIO

The antibacterial potential of Ganoderma against staphylococcal infections The researchers analyzed secondary metabolites from Ganoderma mushrooms against specific proteins from Staphylococcus aureus using molecular docking simulations. Numerous chemicals showed strong binding energy with key protein targets. In particular, ganosinoside A showed significant affinity for aggregation factor A, which was validated by dynamic simulations. In addition, the antibacterial activity of extracts from natural Ganoderma strains against S. aureus was evaluated and was positive, indicating that these extracts are a potential source of new antibiotics. These results provide the basis for further investigation of the antibacterial mechanisms of Ganoderma compounds. https://lnkd.in/eWxGub8k #supplements #ganoderma #naturalhealth #naturalmedicine