Explore the latest in research, methods, and statistics, including topics in clinical research infrastructure, design, conduct, and analysis.
This systematic review and meta-analysis is an update to a previous review of randomized clinical trials examining the association of patient-reported outcome measures used in cancer treatment with overall mortality risk, health-related quality of life, and hospital utilization.
This cross-sectional study examines the use of community-based efforts to increase the level of screening and enrollment of Black and Latinx individuals into Alzheimer disease studies through the Alzheimer’s Disease Neuroimaging Initiative-3 (ADNI3).
This cohort study compares the validity of patient-reported outcome measures with neurophysiological and sensory functional measures for the assessment of chemotherapy-induced peripheral neuropathy among adults in Australia.
This Special Communication proposes expanding clinical research to include rigorous evaluation of multiple data sources and types and to enable reuse of health data for many purposes to produce evidence about medical interventions.
This cross-sectional study compares medical research abstracts written by surgical trainees or senior surgeons vs abstracts generated by artificial intelligence.
This special communication introduces the studies included in this special issue as part of the National Institutes of Health National Institute on Minority Health and Health Disparities Social Epigenomics Program.
This cross-sectional study assesses how frequently research articles published in the clinical journals with high impact factors are preprinted and whether preprinting is associated with changes in media attention and citation counts.
This cohort study assesses the association of poststroke disability with risk of recurrent stroke and major cardiovascular events among participants in 2 randomized clinical trials of secondary stroke prevention.
This cross-sectional study assesses the proportion of immunotherapy trials for breast cancer since 2004 that have failed to report their outcomes, the proportion of these trials that have yielded positive results, and the features associated with both outcomes.
This mixed-methods study of clinical trials conducted during the COVID-19 pandemic surveys principal investigators and project coordinators and summarizes challenges, opportunities, and suggestions for running trials in a pandemic setting.
This meta-analysis of phase 1 trial data from a single institution assesses whether Asian, Hispanic, and non-Hispanic Black trial participants with advanced cancer experience similar response outcomes as non-Hispanic White trial participants.
This diagnostic study examines how a large language model used for title and abstract screening for systematic reviews compares in accuracy and efficiency with conventional screening methods.
This cross-sectional study of US adults examines the geographical distribution of individuals eligible to participate in the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) trial to estimate potential cardiovascular health impacts of implementing the trial findings at state and national levels.
This cross-sectional study examines the availability of consent forms for National Institutes of Health–funded trials on ClinicalTrials.gov.
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