Technobis Crystallization Systems

🚀 #ReactALL: Enhancing solvent retention with #SmartCap technology 🔬 A recent study on the ReactALL system, featuring SmartCap technology, has demonstrated its ability to significantly reduce solvent evaporation, thus solving a major issue in maintaining consistency during experiments. The ReactALL system is an advanced platform for chemical reaction screening, featuring #SmartCap technology to reduce solvent evaporation, with automated sampling, quenching, and dilution for streamlined HPLC vial transfer and high-quality data. 🔬 Key Findings: ➡️ Assessment without sampling: THF was heated under reflux for 20 hours in sealed reactors with no solvent loss, demonstrating the system's efficiency in static conditions. ➡️ Assessment with repeated sampling: Multiple solvents, including MTBE, THF, ethyl acetate, and toluene, were heated to their boiling points with 16 samples taken. Minimal solvent loss (2.1% to 6.6%) was observed, except for MTBE, which had a 13% loss. The retention performance during active sampling highlights how SmartCap technology preserves solvent integrity and prevents evaporation, ensuring precise concentration control for improved reproducibility and accuracy in reaction profiling. Thanks to Hawkins et al. for the insightful work published in Organic Process Research & Development! 📄 Read more here: https://lnkd.in/dePRH7pp #Technobis #ReactionScreening #ReactionProfiling #SolventRetention #AutomaticSampling #ProcessDevelopment #OrganicChemistry

Come meet us in #SanDiego at #AIChE2024! Bring your questions about #chemical #synthesis, #solid-state research, process development, and #formulation to booth #622. Our colleagues Fernando Ferreira, MBA and Carmen Guguta will be there to provide support on how to make your research successful. In addition, if you are interested in learning more about our latest device, the #ReactALL benchtop multiple reactor system for chemical process R&D, now is the perfect time to do so. ReactALL will be displayed and available for live demos during the event. See you there?

🚀 ReactALL: Ensuring reproducibility with automated sampling 🚀 Reproducibility is a cornerstone of successful chemical process scale-up, ensuring that representative aliquots are consistently achieved. The #ReactALL system is an advanced platform for chemical reaction screening, featuring #SmartCap technology with automated sampling, quenching, and dilution for streamlined HPLC vial transfer and high-quality data. We highlight a recently conducted study by a research team at Pfizer, comparing manual and automated sampling methods, and the results speak for themselves. 🔬 Key Findings: ➡️ Homogeneous System: A solution of diphenyl ether in acetonitrile was agitated in five reactors at 500 rpm and 25°C. ReactALL’s automated sampling showed consistent UPLC-MS data with a residual standard deviation of 0.8%-1.5%, closely matching manual sampling (1.4%), confirming its precision and reproducibility. ➡️ Heterogeneous System: A mixture of diphenyl ether and sodium tosylate in toluene was tested under similar conditions. Automated and manual samples yielded nearly identical results, proving the effectiveness of ReactALL in handling both soluble and insoluble components. Thanks to Hawkins et al. for the insightful work published in Organic Process Research & Development! 📄 Read more here: https://lnkd.in/d75V2KhJ #Technobis #ReactionScreening #ProcessChemistry #Automation #AutomatedSampling #HomogeneousReaction #HeterogeneousReaction #Reproducibility

We're excited about attending the American Association of Pharmaceutical Scientists (AAPS) | @aapscomms PharmSci 360 Annual Meeting from 20 to 23 October! We look forward to showcasing our solutions designed to support researchers working in drug discovery, formulation and development. Talk to our team Elrick Cornelius and Thomas Kendall at booth #2531 for more information on how we can improve efficiency and success in your lab. #Technobis #PharmSci360 #AAPS2024 #DrugDiscovery #DrugFormulation #DrugDevelopment #LaboratoryEquipment

We look forward to attending the 25th ACT (Association for Crystallization Technology) #LarsonWorkshop ! Come meet us to learn more about our #crystallization #screening workflow, consisting of #CrystalBreeder, #Crystal16 and #Crystalline, which allow scientists to perform well-controlled crystallization studies from hit and lead identification to process scale-up and formulation. In addition, this is a great opportunity to get a live demo of #ReactALL, our newest device dedicated to #chemical #process research & development.

A heartfelt thank you to everyone who attended the #Crystallization #Workshop last week. Your participation, insightful questions, and positive energy made the event truly memorable. A special shoutout to the speakers for sharing their expertise and insights - your contributions sparked engaging discussions and inspired us all. And a huge thank you to our event partner and host, Politecnico di Torino - to Elena Simone, Daniele Marchisio and their amazing team. We couldn’t have done it without you! 🙌 Here's a throwback photo compilation from the event:

👋 Come say hi at the 5th edition of Pharma Crystallization Summit on 26 and 27 September. Bring along all your questions about #solid-state research, #process #development and #formulation to discuss with our team of experts Fernando Ferreira, MBA and Carmen Guguta. Will we see you there? #Technobis #PharmaCrystallizationSummit #Crystallization #DrugDevelopment #Pharma

#ReactALL: The Future of Reaction Screening! 🌟 We’re excited to share the latest publication, “The ReactALL Platform: Experimental Data and Case Studies”, authored by Joel M. Hawkins, David Pfisterer, Russell F. Algera, and Sebastien Monfette from Pfizer. The Technobis ReactALL platform bridges the gap between route scouting and process optimization, providing an unparalleled solution for small-scale, scale-predictive experimentation in drug development. It features SmartCap™ automated sampling, mechanical agitation, independent temperature control, and real-time visual data capture, ideal for early-stage processes. In the study, ReactALL’s performance was evaluated across four key case studies: ➡ Solvent Retention: Characterized solvent retention across various organic solvents at their boiling points, both with and without sampling. ➡ Sampling Reproducibility: Assessed the consistency and homogeneity of sampling in both homogeneous and heterogeneous mixtures. ➡ Reaction Time Profiles: Compared time profiles for a heterogeneous amine alkylation reaction using ReactALL, a commercial reactor (50-100 mL) with mechanical agitation, and vials agitated with stir bars. ➡ Rapid Determination of Activation Parameters: Utilized the platform’s parallelization and sampling capabilities to gain insights into a model nucleophilic aromatic substitution reaction. We believe ReactALL will revolutionize the drug development process by streamlining early-stage experimentation and delivering highly scale-relevant data. Read the full article here: https://lnkd.in/dYNBjMsC #ReactionScreening #ReactionOptimization #Pharmaceuticals #ProcessChemistry #ReactionKinetics #DrugDevelopment #Chemistry #HTE #Pfizer #Technobis

I want to take a moment to express my heartfelt thanks to my incredible colleague, Elena Simone: your support and guidance in organizing the recent crystallization workshop (September 17-18-19, 2024) at Politecnico di Torino (Lingotto Campus) made a significant impact on its success. It was an amazing experience collaborating with you and bringing together such passionate individuals in our field. Your dedication and expertise not only inspired our research teams but also enriched my own understanding of the subject. Here’s to many more successful projects together! 🙌💼 Many thanks also to the Working Party on Crystallization of the EFCE, Technobis Crystallization Systems (in particular to Sarah Thompson and Roman Maag), Marco Marongiu, Luca Della Valle and to all the speakers: Thomas Kendall, Joop ter Horst, Ana Cruz, Kirstie M., Manuel Henry, Michele Baldrighi, Philippe Fernandes, Marco Rudolf von Rohr, Fabrizia Grepioni, Kerstin Wohlgemuth, Botond Szilagyi, Thomas Vetter, Elodie Verdurand, Fabio Paccanaro, Brian Glennon, Jennifer Webb and the great Megan J Povey! MulMoPro and CREST - Catalytic Reaction Engineering for Sustainable Technologies #Teamwork #Gratitude #CrystallizationWorkshop #Collaboration

Next week we'll be at #OPRD, showcasing the latest addition to our portfolio: #ReactALL - the future of reaction screening. If you’re attending, stop by booth 17, where our experts Roman Maag and Sarah Thompson will be available to give live demonstrations and answer all your questions. This is a fantastic opportunity to get an in-depth look at how this innovative instrument can enhance your synthetic route design, development and optimisation work. #Technobis #OPRDEU24 #ScientificUpdate #Researchanddevelopment #ChemicalSynthesis #LabAutomation