BioISI - Biosystems & Integrative Sciences Institute

Imagine you have tiny building blocks (proteins) that sometimes stick together in a way that isn't good and can make your brain not work well. In this work, researchers found that when calcium is around, these blocks stick together in a different way, making possible to our brain not to become sick (Alzheimer’s Disease). Know more about this work here: https://bioisi.pt/news/83 Read the full paper, first-authored by Ana Carapeto, researcher from the Atomic Force Microscopy and Related Techniques Lab (at BioISI - Biosystems & Integrative Sciences Institute - Faculdade de Ciências da Universidade de Lisboa ), coordinated by Mário Rodrigues (group leader of the same lab), counting with the participation of Patrícia Faísca (group leader of the Biological Physics Lab) and published on Biomolecules journal here: https://bit.ly/47cBx1L #BioISiDigest #alzheimersdisease #AtomicForceMicroscopy #ProteinAggregation

Gabriel Martins, PhD Student at the Molecular Aggregation in Disease Lab (BioISI - Biosystems & Integrative Sciences Institute - Faculdade de Ciências da Universidade de Lisboa), is the first author of a recent paper, published in the Journal of Chemical Information and Modelling (American Chemical Society) and coordinated by Nuno Galamba, group leader of the same Lab. In this study, the authors used two different simulation methods to study the aggregation of alpha-synuclein, a intrinsically disordered protein implicated in Parkinson’s disease (PD). Read this BioISI Digest to find out more about this investigation, which will make possible to study that protein and better understand its aggregation, so that new drug candidates to PD can be developed: https://bioisi.pt/news/81 Read the full paper: https://bit.ly/3XHeSHT #bioisidigest #MolecularSimulation #ComputationalChemistry #parkinsonsdisease

A recent paper, first-authored by Fernanda Murtinheira, PhD Student from the Cell Structure and Dynamics Lab, at BioISI - Biosystems & Integrative Sciences Institute - Faculdade de Ciências da Universidade de Lisboa, and coordinated by Federico Herrera, principal investigator of the same lab, reports the development of a cellular model for the rare neurological disorder Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS). According to Federico Herrera, these findings will have a great positive impact for patients and their families as: "The molecular mechanisms of rare neurodegenerative disorders like ARSACS are poorly understood, and there are no treatments. Big pharma and large research laboratories are not very interested because the number of potential customers is very limited. And yet, these disorders represent a burden for many families and a major scientific challenge for academic laboratories like mine." Find out more: https://bioisi.pt/news/79 Read the full paper: https://bit.ly/4cMDi6Z #bioisinews #bioisidigest #RareDisease #arsacs

BioISI Researchers obtained funding from Fundação para a Ciência e a Tecnologia (FCT), to carry out 7 Exploratory Projects. Célia Rasga, Daniela Ferreira, Federico Herrera, Filipa Calisto, Marisa Maia, Marta Sousa Silva and Noelia Losada García are the names of the seven BioISI scientists who secured up to 50 k€ to perform exploratory projects with a duration of two years each. Know more here: https://bioisi.pt/news/78 Faculdade de Ciências da Universidade de Lisboa Instituto Nacional de Saúde Doutor Ricardo Jorge Universidade de Trás-os-Montes e Alto Douro

Ainda sobre a Conferência MIC-STAND 2024, um evento híbrido, organizado com o apoio do BioISI - Biosystems & Integrative Sciences Institute no âmbito da EuroMIC-European MIC Network COST Association - European Cooperation in Science and Technology, que aconteceu na Faculdade de Ciências da Universidade de Lisboa, entre 24 e 26 de Julho. Conheça o testemunho de Elisabete R. Silva, líder do Bioactive and Multifunctional Materials Lab, e outros detalhes sobre o evento abaixo.

Bruno Victor, Miguel Machuqueiro, Nuno Galamba and Paulo J. Costa - group leaders, respectively, of the Structure-Based Drug Discovery Lab, the Computational BiopHysics Lab, the Molecular Aggregation in Disease Lab and the Computational Chemistry and Molecular Interactions Lab (all from BioISI - Biosystems & Integrative Sciences Institute-Faculdade de Ciências da Universidade de Lisboa) – obtained enhanced computational capacity to develop computational models with application in drug design, within the 4th Edition of the FCT Advanced Computing Projects Call 👏 According to Miguel Machuqueiro: "The computational resources provided by FCT will be an important complement to the BioISI computational infrastructure and is particularly suitable for very ambitious projects, like this one, where long simulations may be pivotal" 👌 Get to know the projects here: https://bioisi.pt/news/77 #BioISINews #AdvancedComputing #DrugDesign

And in the final day of the MIC-STAND Conference, Microbiologically Influenced Corrosion (MIC) was approached in an industrial perspective. Legislation and standardization, as well as case studies and intellectual property protection and funding were the main topics discussed. This meeting was organized with the support of the EuroMIC-European MIC Network COST Association - European Cooperation in Science and Technology Action , and was chaired by the BioISI - Biosystems & Integrative Sciences Institute's Group Leader Elisabete R. Silva. Ana Carapeto and Noelia Losada García were also part of the Organizing Committee. Faculdade de Ciências da Universidade de Lisboa

On this second day of the MIC-STAND Conference, it was time to talk about the detection and monitoring of the Microbiologically Influenced Corrosion (MIC), during the morning. In the afternoon, several strategies and techniques to prevent and control MIC have been discussed. Know more on the conference website (https://mic-stand.pt/) and stay tuned for tomorrow's developments. This meeting is organized with the support of the EuroMIC-European MIC Network COST Action , and is chaired by the BioISI - Biosystems & Integrative Sciences Institute's Group Leader Elisabete R. Silva. Ana Carapeto and @Noelia Losada García are also part of the Organizing Committee. Faculdade de Ciências da Universidade de Lisboa

Today started the MIC-STAND Conference at Faculdade de Ciências da Universidade de Lisboa. Until next Friday, it will be time for an inspiring exploration of the challenges and advancements in Mitigating Microbiologically Influenced Corrosion (MIC) field. Know more on the conference website: https://mic-stand.pt/ This meeting is organized with the support of the EuroMIC-European MIC Network COST Action , and is chaired by the BioISI - Biosystems & Integrative Sciences Institute's Group Leader Elisabete R. Silva. Ana Carapeto and Noelia Losada García are also parte of the Organizing Committee and Hugo Botelho promoted a workshop on " Fluorescence Microscopy and applications to microbiology" within this conference. Photo Credits: BioISI

Federico Herrera e a sua equipa do Laboratório de Estrutura e Dinâmica Celulares do BioISI - Biosystems & Integrative Sciences Institute - Faculdade de Ciências da Universidade de Lisboa receberam financiamento da Ataxia UK para estudar duas doenças neurológicas raras que afetam o equilíbrio, a coordenação e a fala (ataxias). Na Revista Visão / Exame Informática poderá descobrir todos os pormenores sobre este financiamento e perceber como é que esta investigação permitirá "(...) lançar uma nova luz sobre duas doenças raras com pouco interesse para a indústria farmacêutica, mas que constituem dois elevados desafios científicos e biotecnológicos" (Federico Herrera). Leia mais aqui: https://lnkd.in/dVcSubh3 Foto: Pedro Peralta #BioISIInTheMedia #DoençasRaras #Ataxia