iBET - Instituto de Biologia Experimental e Tecnológica

Because real problems need real science. *WE ARE iBET* #science #biotechnology #biopharma #food #nutraceuticals

I look forward to speaking at the Bioprocessing Summit in Barcelona, 18-20 March, 2025! Join me as we delve into the latest advancements shaping the future of bioproduction across a range of themes and modalities.

Huge thank you to the incredible women who joined us today for the Women in NextGen Biomed Panel Discussion. The discussion focused on breaking down barriers in STEM, addressing the glass ceiling within biomedicine, and highlighting the women who are leading the charge in the future of science. Thank you again to; • Amita Vaidya, Ph.D., Principal Scientist, Sanofi • Patricia Gomes-Alves, Head of the Sanofi Satellite Lab, iBET - Instituto de Biologia Experimental e Tecnológica • Mihaela Bozic, Scientist, T-Therapeutics Ltd • Alexandria (Alex) Cogdill, MEng, PhD, Head of Strategic Initiatives, Daiichi Sankyo #NextGenBiomed2025 #NGB2025 #Immunotherapy #Vaccines #Biologics #WomenInSTEM #Biomedicine

📢[New Publication – Controlled Activation Modulates T-cell Expansion and Phenotype in Stirred-tank Bioreactors] Autologous #celltherapies using chimeric antigen receptor (CAR) #Tcells have shown significant clinical success in #HematologicCancers. 🧪 However, manufacturing challenges persist - particularly in scaling up production to meet the demands of multi-dose regimens. Additionally, maintaining tight control over critical process parameters throughout the distinct stages of cell production is essential for optimizing key phenotypic characteristics of #CARTcell products, ultimately enhancing therapeutic outcomes. In this latest study, researchers at iBET - Instituto de Biologia Experimental e Tecnológica propose an integrated manufacturing process in #stirredtankbioreactors (STBs) for controlled T-cell activation and expansion. Key findings: 👉 Tailored stirring profile of STBs, combined with anti-CD3/CD28 functionalized microbeads, enables controlled T-cell activation without requiring additional washing steps. 👉 Implemented strategy led to a 10-fold increase in T-cell numbers compared to static cultures, reaching 2.5x10^7 cells/mL in 10 days. 👉 Higher CD8+ T-cells proportion and lower expression of exhaustion markers (PD-1, LAG-3 and TIM-3) obtained in STBs relative to static cultures. This new approach offers a promising strategy for the scalable and controlled #manufacturing of T-cell therapies, paving the way for more effective and cost-efficient #immunotherapies. Congratulations to the authors! 🎉 Margarida Costa Constança Costa Leonor Matos Maria João C. Sebastião Nádia Duarte, PhD Marta Costa Margarida Serra Read the full paper here 🔗https://lnkd.in/dnaAh-CT This work was developed in the context of #CARTool project: 🔗 https://lnkd.in/dFNAqqBp #CellTherapy #Immunotherapy #Bioprocessing #TCells #Biomanufacturing

🎉Congratulations to Nuno Lopes on successfully defending his PhD in #MolBios at ITQB NOVA! ➡️Nuno's thesis on “Assessing tumour-associated macrophage phenotype and glycan signatures in breast cancer: Insights from 3D cell models and protein microarrays” was supervised by Catarina Brito (iBET’s Advanced Cell Models Lab) and co-supervised by Angelina de Sá Palma at Faculdade de Ciências e Tecnologia da Universidade NOVA de Lisboa. The research work was developed within the scope of the project “#GlycoTAM - Cracking glycan-lectin interactions to target immunosuppressive macrophages in triple-negative breast cancer”, funded by Fundação para a Ciência e a Tecnologia (FCT) (PTDC/BTM-TEC/0432/2021). Congrats Dr Lopes on this significant milestone. Wishing you continued success for the future! 🚀 Know more about iBET's Advanced Cell Models Lab 🔗https://lnkd.in/d9t2zCFX #CancerResearch #3DCellModels #WeareiBET #PhDdefense

📢[#iBET is hiring! – MSc Research Fellowship] iBET - Instituto de Biologia Experimental e Tecnológica’s Natural Bioactives & Nutraceuticals Team is currently recruiting one MSc Research Fellow to join an applied research project within the context of the #VIIAFOOD Agenda – funded by the Recovery and Resilience Plan. This is an exciting opportunity to work in a wide research network in close contact with partners of the national #agrifood industry. In this role, you will 👉 Analyse #oliveoil samples using fast screening methodologies. 👉Identify and quantify bioactive compounds present in olive oil samples using #HPLC, #GC, and GCxGC-MS. Key requirements: ✅ MSc Degree in Chemistry, Chemical Engineering, Biochemistry, Biotechnology, Pharmaceutical Sciences, and related areas. ✅ Experience in fast screening methodologies, namely Infrared Spectroscopy (FTIR), Fluorescence Spectroscopy, Raman Spectroscopy and Nuclear Magnetic Resonance (NMR) Spectroscopy. ✅Experience in analytical methodologies, namely Liquid and Gas chromatography (HPLC, GC) and Multidimensional #chromatography (e.g., GCxGC-MS). Learn more about iBET and the job offer here: 🔗 https://lnkd.in/dEVky4wF 🗓️Application deadline: 15th March 📧Send your CV, diploma and motivation letter to jobs@ibet.pt #sciencejobs #naturalbioactives #oliveoil

We are thrilled to share that our scientist Patricia Gomes-Alves, Head of Sanofi Satellite Lab at #iBET, will be participating in the Women in NextGen Biomed Panel at NextGen Biomed by Oxford Global 2025! Join Patricia and other incredible women as they discuss breaking barriers, driving innovation, and leading in #STEM. 🔬👩🔬

🎉Congratulations to our newest #PhD graduate Rita Fernandes on successfully defending her PhD in #MolecularBiosciences at ITQB NOVA! ➡️Rita’s thesis "Advancing Biotherapeutic Manufacturing Through New Purification Strategies: Focus on Enveloped Virus-Based Targets" was conducted at iBET’s Downstream Process Development Lab under the supervision of Cristina Peixoto, and co-supervised by José Paulo Mota (FCT-NOVA). Her research focused on developing innovative #purification and #analytical technologies to tackle the inherent complexity and fragility of enveloped #bionanoparticles. She successfully isolated diverse enveloped bioparticles with enhanced quality, gaining a deeper understanding of the #bioprocess and improving product recovery, #stability, and purity. This work was carried out in collaboration with several external partners, including the Ligand Discovery Group at Thermo Fisher Scientific and the Bioprocess Engineering Group at Max Planck Institute for Dynamics of Complex Technical Systems. 🤝 Congrats Dr Fernandes on this significant milestone. Wishing you all the best for the future! 🚀 Know more on iBET's DSP Dev Lab 🔗 https://lnkd.in/ggUjApBh #PhD #GeneTherapy #Bionanoparticles #ViralVectors #WeareiBET

[Welcome to the team Andreia & Ana! ]👋 We are thrilled to have you join the iBET - Instituto de Biologia Experimental e Tecnológica team. 🥼Andreia Verissimo ➡️ Senior Scientist, Late-Stage R&D and Bioproduction Unit Andreia is passionate about the interplay of #ProteinStructure and function, particularly in challenging membrane-bound protein complexes. With years of experience overseeing the scientific and day-to-day operations of core facilities responsible for the production, characterization, and crystallization of #recombinantproteins, she brings a wealth of experience to our LS-BPU team. 👉At #iBET, Andreia will lead projects focused on producing and characterizing complex #biopharmaceuticals in collaboration with industry and academic institutions. 👩💻Ana Luisa Gomes ➡️External Affairs Manager, External Affairs After her PhD in Molecular Mechanisms of Disease, Ana transitioned into #ScienceManagement, gaining extensive experience in science project management and institutional communication across both industry and academia. 👉At #iBET, Ana will oversee institutional projects and visits, serve as a point-of-contact for research consortia, and manage iBET’s internal innovation program. A warm welcome to #iBET, Andreia and Ana! We wish you all the best for this new stage of your professional careers. 🚀 #newhire #WeareiBET #iBET #atmps #biotechnology #science

✨ Today, on #InternationalDayofWomenandGirlsinScience, we celebrate the remarkable contributions of female scientists worldwide in advancing science and expanding knowledge across all fields. At iBET - Instituto de Biologia Experimental e Tecnológica, we are proud to recognize the incredible women on our team who push the boundaries of discovery every day ... with passion, creativity, and determination! 👩🔬🔬 Thank you for your dedication and for paving the way for future generations! Together, #WeareiBET #WomenInScience #iBET #STEM #InternationalDayOfWomenAndGirlsInScience #Innovation