Normal brain function highly relies on the appropriate functioning of astrocytes. These glial
cells are strategically situated between blood vessels and neurons, provide significant
substrate support to neuronal demand, and are sensitive to neuronal activity and energy-
related molecules. Astrocytes respond to many metabolic conditions and regulate a wide
array of physiological processes, including cerebral vascular remodeling, glucose sensing,
feeding, and circadian rhythms for the control of systemic metabolism and behavior-related …