… bronchial epithelial cells (16HBE cells) in vitro and bioinformatics analysis were used to
analyze the methylation level of TP53 and p16 and understand whether DNA methylation can …

… To examine the mechanism of hexavalent chromium [Cr(VI)]-… exposed to chromate and
16HBE cells treated Cr(VI) in vitro. … identifying the breaks of DNA double strand and performing …

… breaks, genetic instability, and chromosome fragility.Citation 27–29 In our previous study, a
… of p16 gene. No change of DNA methylation was found in TP53 gene, although TP53 gene …

… association between occupational hexavalent chromium [Cr(VI)] … trend in methylation of the
p16 gene promoter region. … from stresses, including apoptotic signals that cause cell rupture …

… (III)] is considered non-carcinogenic, hexavalent chromium [Cr(… The p16 tumor suppressor
functions by inhibiting CDK4 and … chromate-exposed workers as well as in 16HBE cells treated …

… Hexavalent chromium [Cr(VI)] has been widely used in many … that caused p16 gene promoter
methylation in chromate lung … p53 binding protein 1 (53BP1) in human bronchial epithelial …

… Hexavalent chromium [Cr(VI)] compounds are widely used in industry and agriculture and …
These genes were mostly involved in p53 signaling pathway, MAPK signaling pathway, DNA …

… the expression levels of p16 were lower but the methylation levels of … Methylation levels of
P16 and TP53 that are involved in DNA strand breakage of 16HBE cells treated by hexavalent …

… to heavy metals, such as hexavalent chromium, nickel, and … promoter methylation and
decreased expression of p16 and … of TP53 and plays an important role in DNA damage repair […

… negatively with the treated concentrations of Cr (VI).Citation 72 Methylations in … 88 Cr (VI)-induced
hypermethylation of P16 and TP53 were observed in DNA strand breakage in 16HBE …