Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis
JE Rager, M Suh, GA Chappell, CM Thompson… - Toxicology letters, 2019 - Elsevier
Inhalation exposure to hexavalent chromium [Cr (VI)] is associated with increased risk of
lung cancer with a mode of action (MOA) postulated to involve non-mutagenic key events,
yet molecular-level events remain uncertain. Previously-published transcriptomic studies in
the lung and lung cells were reviewed to evaluate molecular events in the MOA. This study
aimed to (i) identify biological pathways that are consistently modulated by Cr (VI) in the lung
through the compilation of transcriptomic-based databases,(ii) predict interactions between …
lung cancer with a mode of action (MOA) postulated to involve non-mutagenic key events,
yet molecular-level events remain uncertain. Previously-published transcriptomic studies in
the lung and lung cells were reviewed to evaluate molecular events in the MOA. This study
aimed to (i) identify biological pathways that are consistently modulated by Cr (VI) in the lung
through the compilation of transcriptomic-based databases,(ii) predict interactions between …
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