與「"author:Barrio-Hernandez I"」相符的使用者個人學術檔案
![]() | Inigo Barrio-HernandezWelcome Sanger Institute 在 ebi.ac.uk 的電子郵件地址已通過驗證 被引用 6779 次 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Clustering predicted structures at the scale of the known protein universe
Proteins are key to all cellular processes and their structure is important in understanding
their function and evolution. Sequence-based predictions of protein structures have …
their function and evolution. Sequence-based predictions of protein structures have …
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
INTRODUCTION The emergence of three lethal coronaviruses in< 20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes
J Schwartzentruber, S Cooper, JZ Liu… - Nature …, 2021 - nature.com
Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Network expansion of genetic associations defines a pleiotropy map of human cell biology
I Barrio-Hernandez, J Schwartzentruber… - Nature Genetics, 2023 - nature.com
Interacting proteins tend to have similar functions, influencing the same organismal traits.
Interaction networks can be used to expand the list of candidate trait-associated genes from …
Interaction networks can be used to expand the list of candidate trait-associated genes from …
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
V Akimov, I Barrio-Hernandez, SVF Hansen… - Nature structural & …, 2018 - nature.com
Ubiquitination is a post-translational modification (PTM) that is essential for balancing
numerous physiological processes. To enable delineation of protein ubiquitination at a site …
numerous physiological processes. To enable delineation of protein ubiquitination at a site …
Towards a structurally resolved human protein interaction network
Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …
protein interactions. Their atomic details are critical to studying their molecular mechanisms …
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …
Toward understanding the biochemical determinants of protein degradation rates
M Correa Marrero, I Barrio-Hernandez - ACS omega, 2021 - ACS Publications
Protein degradation is a key component of the regulation of gene expression and is at the
center of several pathogenic processes. Proteins are regularly degraded, but there is large …
center of several pathogenic processes. Proteins are regularly degraded, but there is large …
[HTML][HTML] Network analysis of genome-wide association studies for drug target prioritisation
I Barrio-Hernandez, P Beltrao - Current Opinion in Chemical Biology, 2022 - Elsevier
Over the past decades, genome-wide association studies (GWAS) have led to a dramatic
expansion of genetic variants implicated with human traits and diseases. These advances …
expansion of genetic variants implicated with human traits and diseases. These advances …