Wiskott-Aldrich syndrome protein family members (WASF) regulate the dynamics of the actin
cytoskeleton, which plays an instrumental role in cancer metastasis and invasion …

In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational
modifications (PTMs), including phosphorylation of Ser/Thr residues and oxidation of …

Wiskott–Aldrich Syndrome Protein Family (WASF) members regulate actin cytoskeletal
dynamics, and WASF3 is directly associated with breast cancer metastasis and invasion …

Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that bind and recruit
an E3 ubiquitin ligase to a targeted protein of interest, often through the utilization of a small …

Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in
a multitude of diseases. Although significant efforts have been put forth to develop kinase …

Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide
array of signaling pathways and physiological processes. Protein–protein interactions …

Protein kinases are critical components of diverse signaling pathways. While all kinases
share a conserved kinase domain, there is considerable diversity among kinases within the …

The ubiquity and variety of protein-protein interactions (PPI) mediating the human protein
interactome make them an attractive yet daunting target for investigation and therapeutic …

Rink amide MBHA resin along with N-α-Fmoc protected amino acids were purchased from
Novabiochem.(S)-NFmoc-2-(4'-pentenyl) alanine and Grubb's catalyst (1st Generation) were …