與「"author:Bouhaddou M"」相符的使用者個人學術檔案

Mehdi Bouhaddou

Assistant Professor, UCLA
在 ucla.edu 的電子郵件地址已通過驗證
被引用 8428 次

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection

M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Evolution of enhanced innate immune evasion by SARS-CoV-2

LG Thorne, M Bouhaddou, AK Reuschl… - Nature, 2022 - nature.com
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance
human-to-human transmission,. Although much effort has focused on the characterization of …

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts… - Science, 2020 - science.org
INTRODUCTION The emergence of three lethal coronaviruses in< 20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

KM White, R Rosales, S Yildiz, T Kehrer, L Miorin… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral …

Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses

R Wang, CR Simoneau, J Kulsuptrakul, M Bouhaddou… - Cell, 2021 - cell.com
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena… - Cell host & …, 2022 - cell.com
SARS-CoV-2 lineages have diverged into highly prevalent variants termed" variants of
concern"(VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in …

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

AS Mendiola, Z Yan, K Dixit, JR Johnson… - Nature …, 2023 - nature.com
Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …

The landscape of human cancer proteins targeted by SARS-CoV-2

B Tutuncuoglu, M Cakir, J Batra, M Bouhaddou… - Cancer discovery, 2020 - AACR
The mapping of SARS-CoV-2 human protein–protein interactions by Gordon and colleagues
revealed druggable targets that are hijacked by the virus. Here, we highlight several …

A protein interaction landscape of breast cancer

M Kim, J Park, M Bouhaddou, K Kim, A Rojc, M Modak… - Science, 2021 - science.org
INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …