Protein kinases are coded by more than 2,000 genes and thus constitute the largest single
enzyme family in the human genome. Most cellular processes are in fact regulated by the …

Tumour oncogenes include transcription factors that co-opt the general transcriptional
machinery to sustain the oncogenic state, but direct pharmacological inhibition of …

Activation of signal transduction kinase cascades has been shown to alter androgen
receptor (AR) activity. Although it has been suggested that changes in AR phosphorylation …

Molecular signatures have identified several subsets of diffuse large B cell lymphoma
(DLBCL) and rational targets within the B cell receptor (BCR) signaling axis. The OxPhos …

Genotypic differences greatly influence susceptibility and resistance to disease.
Understanding genotype–phenotype relationships requires that phenotypes be viewed as …

The addition of the monosaccharide β-N-acetyl-d-glucosamine to proteins (O-GlcNAc
glycosylation) is an intracellular, post-translational modification that shares features with …

The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that
transduce and integrate extracellular stimuli into coordinated cellular response. Here, we …

The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development,
tumorigenesis, and pluripotency, but their exact functions are poorly understood. Here, we …

The covalent modification of intracellular proteins by O-linked β-N-acetylglucosamine (O-
GlcNAc) is emerging as a crucial regulatory posttranslational modification akin to …

Eradicating tumor dormancy that develops following epidermal growth factor receptor
(EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small cell lung cancer …