Clinical symptoms, signs and tests for identification of impending and current water‐loss dehydration in older people

L Hooper, A Abdelhamid, NJ Attreed… - Cochrane Database …, 2015 - cochranelibrary.com
Background There is evidence that water‐loss dehydration is common in older people and
associated with many causes of morbidity and mortality. However, it is unclear what clinical …

A perspective on RNAi-based biopesticides

SJ Fletcher, PT Reeves, BT Hoang… - Frontiers in plant …, 2020 - frontiersin.org
Sustainable agriculture relies on practices and technologies that combine effectiveness with
a minimal environmental footprint. RNA interference (RNAi), a eukaryotic process in which …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Clay nanosheets for topical delivery of RNAi for sustained protection against plant viruses

N Mitter, EA Worrall, KE Robinson, P Li, RG Jain… - Nature plants, 2017 - nature.com
Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance
in plants represents an attractive alternative to transgenic RNA interference (RNAi) …

Is there a role for patients and their relatives in escalating clinical deterioration in hospital? A systematic review

AK Albutt, JK O'Hara, MT Conner… - Health …, 2017 - Wiley Online Library
Background Measures exist to improve early recognition of, and response to, deteriorating
patients in hospital. However, deteriorating patients continue to go unrecognized. To …

Sage handbook of mentoring and coaching in education

CA Mullen, SJ Fletcher - 2012 - torrossa.com
founded a Special Interest Group for Mentoring and Coaching for the British Educational
Research Association and she runs on-line outreach lists promoting discussion about …

Foliar application of clay-delivered RNA interference for whitefly control

RG Jain, SJ Fletcher, N Manzie, KE Robinson, P Li… - Nature Plants, 2022 - nature.com
Whitefly (Bemisia tabaci) is a phloem-feeding global agricultural pest belonging to the order
Hemiptera. Foliar application of double-stranded RNA (dsRNA) represents an attractive …

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

O Leiter, D Brici, SJ Fletcher, XLH Yong… - Nature …, 2023 - nature.com
The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

M Medici, E Porcu, G Pistis, A Teumer, SJ Brown… - PLoS …, 2014 - journals.plos.org
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population.
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of …

SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects

SJ Fletcher, B Johnson, GC Lowe… - The Journal of …, 2015 - Am Soc Clin Investig
Inherited thrombocytopenias are a group of disorders that are characterized by a low platelet
count and are sometimes associated with excessive bleeding that ranges from mild to …