與「"author:Fraser JS"」相符的使用者個人學術檔案
![]() | James S. FraserProfessor, University of California San Francisco 在 ucsf.edu 的電子郵件地址已通過驗證 被引用 16359 次 |
Integrative, dynamic structural biology at atomic resolution—it's about time
H Van Den Bedem, JS Fraser - Nature methods, 2015 - nature.com
Biomolecules adopt a dynamic ensemble of conformations, each with the potential to
interact with binding partners or perform the chemical reactions required for a multitude of …
interact with binding partners or perform the chemical reactions required for a multitude of …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Large language models generate functional protein sequences across diverse families
Deep-learning language models have shown promise in various biotechnological
applications, including protein design and engineering. Here we describe ProGen, a …
applications, including protein design and engineering. Here we describe ProGen, a …
Immunoglobulin-like domains on bacteriophage: weapons of modest damage?
Recent work has shown that Immunoglobulin-like (Ig-like) domains occur frequently on the
surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to …
surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to …
EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of
validation metrics to independently assess map quality and model geometry. We report …
validation metrics to independently assess map quality and model geometry. We report …
Keep on moving: discovering and perturbing the conformational dynamics of enzymes
Conspectus Because living organisms are in constant motion, the word “dynamics” can hold
many meanings to biologists. Here we focus specifically on the conformational changes that …
many meanings to biologists. Here we focus specifically on the conformational changes that …
Accessing protein conformational ensembles using room-temperature X-ray crystallography
JS Fraser, H Van Den Bedem… - Proceedings of the …, 2011 - National Acad Sciences
Modern protein crystal structures are based nearly exclusively on X-ray data collected at
cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little …
cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little …
Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine
BB Williams, AH Van Benschoten, P Cimermancic… - Cell host & …, 2014 - cell.com
Several recent studies describe the influence of the gut microbiota on host brain and
behavior. However, the mechanisms responsible for microbiota-nervous system interactions …
behavior. However, the mechanisms responsible for microbiota-nervous system interactions …
Hidden alternative structures of proline isomerase essential for catalysis
JS Fraser, MW Clarkson, SC Degnan, R Erion, D Kern… - Nature, 2009 - nature.com
A long-standing challenge is to understand at the atomic level how protein dynamics
contribute to enzyme catalysis. X-ray crystallography can provide snapshots of …
contribute to enzyme catalysis. X-ray crystallography can provide snapshots of …
[HTML][HTML] Systematic functional prioritization of protein posttranslational modifications
Protein function is often regulated by posttranslational modifications (PTMs), and recent
advances in mass spectrometry have resulted in an exponential increase in PTM …
advances in mass spectrometry have resulted in an exponential increase in PTM …