Biomolecules adopt a dynamic ensemble of conformations, each with the potential to
interact with binding partners or perform the chemical reactions required for a multitude of …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Deep-learning language models have shown promise in various biotechnological
applications, including protein design and engineering. Here we describe ProGen, a …

Recent work has shown that Immunoglobulin-like (Ig-like) domains occur frequently on the
surface of tailed dsDNA bacteriophages. Several of these Ig-like domains are added to …

Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of
validation metrics to independently assess map quality and model geometry. We report …

Conspectus Because living organisms are in constant motion, the word “dynamics” can hold
many meanings to biologists. Here we focus specifically on the conformational changes that …

Modern protein crystal structures are based nearly exclusively on X-ray data collected at
cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little …

Several recent studies describe the influence of the gut microbiota on host brain and
behavior. However, the mechanisms responsible for microbiota-nervous system interactions …

A long-standing challenge is to understand at the atomic level how protein dynamics
contribute to enzyme catalysis. X-ray crystallography can provide snapshots of …

Protein function is often regulated by posttranslational modifications (PTMs), and recent
advances in mass spectrometry have resulted in an exponential increase in PTM …